高召兵 - 中国科学院上海药物研究所 -

个人简介

教育背景 2006-10--2010-03 约翰霍普金斯大学医学院博士后 2003-09--2006-06 中科院上海药物所博士研究生工作简历 2020-08~现在, 中国科学院上海药物研究所, 副所长、神经精神疾病研究中心主任 2016-10~现在, 中国科学院上海药物研究所, 课题组长 2013-10~现在, 中科院上海药物研究所, 研究员 2010-04~现在, 中科院上海药物所, 副研究员 2006-10~2010-03,约翰霍普金斯大学医学院, 博士后 2003-09~2006-06,中科院上海药物所, 博士研究生社会兼职 2021-07-01-今,上海市神经科学会, 理事 2020-07-01-今,中国药理学会, 理事 2020-04-30-今,中国抗癫痫协会药物治疗专业委员会, 委员

研究领域

离子通道药理学：围绕与神经系统重大疾病有关的离子通道为中心，建立离子通道药物研发平台，推进离子通道新机制、新功能研究，发现新型离子通道，发展新型调制剂，开发靶向离子通道的抗癫痫新药。

近期论文

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Direct Identification of Complex Glycans via a Highly Sensitive Engineered Nanopore, Journal of the American Chemical Society, 2024, Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses, Nature Chemical biology, 2024, Characterization of the role of TMEM175 in an in vitro lysosomal H+ fluxes model, FEBS JOURNAL, 2023, 第 10 作者通讯作者 Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2, CELL DISCOVERY, 2023, 第 20 作者通讯作者 TRPM7生理病理学功能及其小分子调节剂的发现, Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators, 生物化学与生物物理进展, 2023, 第 3 作者 Ligand activation mechanisms of human KCNQ2 channel, NATURE COMMUNICATIONS, 2023, 第 15 作者通讯作者 Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies, Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies, CELL RESEARCH, 2023, 第 12 作者通讯作者 Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil, NEUROSCIENCE BULLETIN, 2023, 第 4 作者通讯作者 Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered ��-Hemolysin Nanopores, Journal of the American Chemical Society, 2023, 第 9 作者通讯作者 Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel, ACTA PHARMACOLOGICA SINICA, 2023, 第 8 作者通讯作者 Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluoroazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 第 9 作者通讯作者 Why is the SARS-CoV-2 Omicron variant milder?, Why is the SARS-CoV-2 Omicron variant milder?, 创新(英文), 2022, 第 9 作者通讯作者 Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates, ACTA PHARMACOLOGICA SINICA, 2022, 第 10 作者通讯作者 SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs, ACTA PHARMACOLOGICA SINICA, 2022, 第 4 作者通讯作者 Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution, ADVANCED SCIENCE, 2021, 第 9 作者 SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, CELL RESEARCH, 2021, 第 34 作者通讯作者 Sanguinarine is an agonist of TRPA1 channel, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 第 6 作者通讯作者 An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy, NATURE BIOMEDICAL ENGINEERING, 2021, 第 12 作者 Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 第 10 作者通讯作者 Identification of 2-substituted pyrrolo1,2-bpyridazine derivatives as new PARP-1 inhibitors, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 第 5 作者 CCT128930 is a novel and potent antagonist of TRPM7 channel, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 第 5 作者通讯作者 Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core, Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core, ACTA PHARMACOLOGICA SINICA, 2020, 第 5 作者通讯作者 Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels, Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels, ACTA PHARMACOLOGICA SINICA, 2020, 第 8 作者通讯作者 Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels, inhibitoryeffectsoflappaconitineontheneuronalisoformsofvoltagegatedsodiumchannels, ACTA PHARMACOLOGICA SINICA, 2019, 第 5 作者通讯作者 Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models, SCIENCE TRANSLATIONAL MEDICINE, 2019, 第 25 作者 A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues, MOLECULAR PHARMACOLOGY, 2019, 第 6 作者通讯作者 Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity, ACS MEDICINAL CHEMISTRY LETTERS, 2019, 第 4 作者通讯作者 High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer’s disease mice, High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice, National Science Review, 2019, 第 8 作者通讯作者