熊兵 - 中国科学院上海药物研究所 -

个人简介

教育经历 2000.9-2003.7 中国科学院上海药物研究所理学博士 1997.9-2000.7 中国科学院近代物理研究所理学硕士 1993.9-1997.7 徐州师范大学理学学士工作经历 2005.12---至今中国科学院上海药物研究所；副研究员，研究员，博士生导师 2003.10-2005.12 加拿大McGill大学结构生物学中心；访问学者

研究领域

1.基于结构/片段药物发现方法学 2.蛋白翻译后修饰体系的创新药物研究 3.表观遗传相关化学生物学研究

近期论文

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1.Hu J, Wang Y, Li Y, Xu L, Cao D, Song S, Damaneh MS, Wang X, Meng T, Chen YL, Shen J, Miao Z, Xiong B*. Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor. Eur J Med Chem. 2017 Sep 8;137:176-195. doi: 10.1016/j.ejmech.2017.05.049. 2.Chen L, Chen D, Tang L, Ren J, Chen J, Zhen X, Liu YC, Zhang C, Luo H, Shen J, Xiong B*. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors. Bioorg Med Chem. 2017 Jul 1;25(13):3315-3329. doi: 10.1016/j.bmc.2017.04.019. 3.Zhang Y, Liu H, Zhang Z, Wang R, Liu T, Wang C, Ma Y, Ai J, Zhao D, Shen J, Xiong B*. Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors. Molecules. 2017 Apr 5;22(4). pii: E583. doi: 10.3390/molecules22040583. 4. Zhang Z, Zhao D, Dai Y, Cheng M, Geng M, Shen J, Ma Y, Ai J, Xiong B*. Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors. Molecules. 2016 Oct 23;21(10). 5. Ren J, Xu W, Tang L, Su M, Chen D, Chen YL, Zang Y, Li J, Shen J, Zhou Y, Xiong B*. Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4472-6. doi: 10.1016/j.bmcl.2016.07.074. 6. Yu JL, Chen TT, Zhou C, Lian FL, Tang XL, Wen Y, Shen JK, Xu YC, Xiong B*, Zhang NX. NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds. Acta Pharmacol Sin. 2016 Jul;37(7):984-93. doi: 10.1038/aps.2016.19. 7. Liu TC, Peng X, Ma YC, Ji YC, Chen DQ, Zheng MY, Zhao DM, Cheng MS, Geng MY, Shen JK, Ai J, Xiong B*. Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors. Acta Pharmacol Sin. 2016 May;37(5):698-707. doi: 10.1038/aps.2016.11. 8. Hu J, Wang X, Chen L, Huang M, Tang W, Zuo J, Liu YC, Shi Z, Liu R, Shen J, Xiong B*. Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors. Bioorg Med Chem Lett. 2016 Feb 1;26(3):721-5. doi: 10.1016/j.bmcl.2016.01.006. 9. Ma Y, Sun G, Chen D, Peng X, Chen YL, Su Y, Ji Y, Liang J, Wang X, Chen L, Ding J, Xiong B*, Ai J, Geng M, Shen J. Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors. J Med Chem. 2015 Mar 12;58(5):2513-29. doi: 10.1021/jm502018y. 10. Zhao L, Wang Y, Cao D, Chen T, Wang Q, Li Y, Xu Y, Zhang N, Wang X, Chen D, Chen L, Chen YL, Xia G, Shi Z, Liu YC, Lin Y, Miao Z, Shen J, Xiong B*. Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization. J Med Chem. 2015 Feb 12;58(3):1281-97. doi: 10.1021/jm501504k. 11.Ren J, Yang M, Liu H, Cao D, Chen D, Li J, Tang L, He J, Chen YL, Geng M, Xiong B*, Shen J. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Biena ymé reaction and their Hsp90 inhibitory activity. Org Biomol Chem. 2015 Feb 7;13(5):1531-5. doi: 10.1039/c4ob01865f. 12. Chen G, Yin Q, Yin J, Gu X, Liu X, You Q, Chen YL, Xiong B*, Shen J. Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation. Org Biomol Chem. 2014 Dec 28;12(48):9781-5. 13. Chen D, Shen A, Li J, Shi F, Chen W, Ren J, Liu H, Xu Y, Wang X, Yang X, Sun Y, Yang M, He J, Wang Y, Zhang L, Huang M, Geng M, Xiong B*, Shen J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur J Med Chem. 2014 Nov 24;87:765-81. doi: 10.1016/j.ejmech.2014.09.065. 14. Li S#, Xiong B#, Xu Y, Lu T, Luo X, Luo C, Shen J, Chen K, Zheng M, Jiang H. Mechanism of the All-α to All-β Conformational Transition of RfaH-CTD: Molecular Dynamics Simulation and Markov State Model. J Chem Theory Comput. 2014 Jun 10;10(6):2255-64. doi: 10.1021/ct5002279. 15. Ren J, Li J, Wang Y, Chen W, Shen A, Liu H, Chen D, Cao D, Li Y, Zhang N, Xu Y, Geng M, He J, Xiong B*, Shen J. Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2525-9. doi: 10.1016/j.bmcl.2014.03.100. 16.Gu X, Chen L, Wang X, Liu X, You Q, Xi W, Gao L, Chen G, Chen YL, Xiong B*, Shen J. Direct glycosylation of bioactive small molecules with glycosyl iodide and strained olefin as acid scavenger. J Org Chem. 2014 Feb 7;79(3):1100-10. 17. Yu Z, Ma YC, Ai J, Chen DQ, Zhao DM, Wang X, Chen YL, Geng MY, Xiong B*, Cheng MS, Shen JK. Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations. Acta Pharmacol Sin. 2013 Nov;34(11):1475-83. doi: 10.1038/aps.2013.85. 18. Zou Y, Li L, Chen W, Chen T, Ma L, Wang X, Xiong B*, Xu Y, Shen J. Virtual screening and structure-based discovery of indole acylguanidines as potent β-secretase (BACE1) inhibitors. Molecules. 2013 May 16;18(5):5706-22. doi: 10.3390/molecules18055706. 19. Zhu L, Li Y, Qiu L, Su M, Wang X, Xia C, Qu Y, Li J, Li J, Xiong B*, Shen J. Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors. ChemMedChem. 2013 Jul;8(7):1104-16. doi: 10.1002/cmdc.201300104. 20. Zhao L, Cao D, Chen T, Wang Y, Miao Z, Xu Y, Chen W, Wang X, Li Y, Du Z, Xiong B*, Li J, Xu C, Zhang N, He J, Shen J. Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain. J Med Chem. 2013 May 23;56(10):3833-51. doi: 10.1021/jm301793a.