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1.Berberine, and Its More Biologically Available Derivative Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for The Action of Berberine to Activate AMPK and Improve Insulin Action. Turner,N#; Li,JY#; Gosby,A#; To,S; Cheng,Z;, Miyoshi,H; Taketo, M; Cooney,G; Kraegen,E; David,J; Hu,LH*.Li,J*. Ye,JM*. Diabetes.2008, 57:1414-1418.（#，共同第一作者）
2.8,8-Dimethyldihydroberberine with Improved Bioavailability and Oral Efficacy on Obese and Diabetic Mouse Models. Cheng,Z; Chen,AF; Wu,F; Sheng,L; Zhang,HK; Gu,M; Li,YY; Zhang,LN; Hu,LH*; Li,JY*; Li,J*.Bioorganic Medicinal Chemistry.2010, 18:5915-5924.
3.A High-throughput Assay for Modulators of Mitochondrial Membrane Potential Identifies a Novel Compound with Beneficial Effects on db/db Mice.Qiu,BY; Turner,N; Li,YY;Gu,M; Huang,MW; Wu,F; Pang,T; Nan,FJ; Ye,JM; Li,JY*; Li,J*.Diabetes. 2010, 59:256-265.
4.Novel Small-Molecule AMPK Activator Orally Exerts Beneficial Effects on Diabetic db/db Mice.Li,YY; Yu,LF; Zhang,LN; Qiu,BY; Su,MB; Wu,F;Chen,DK; Pang,T; Gu,M; Zhang,W; Ma,WP; Jiang,HW; Li,JY*; Nan, FJ*;Li,J*. Toxicology and Applied Pharmacology. 2013, 273:325-334.
5.A Novel Chemical Uncoupler Ameliorates Obesity and Related Phenotypes in Mice with Diet-induced Obese by Modulating Energy Expenditure and Food Intake. Fu,YY; Zhang,M; Turner,N; Zhang,LN; Dong,TC; Gu,M; Leslie,SJ; Li, JY*; Nan,FJ*; Jia,Li*. Diabetologia. 2013, 56(10):2297-2307.
6.Novel Small-molecule AMP-activated Protein Kinase Allosteric Activator with Beneficial Effects in db/db Mice. Zhang,LN; Xu,L; Zhou,HY; Wu,LY; Li,YY; Pang ,T; Xia,CM; Qiu,BY; Gu,M; Dong,TC; Li,JY*;Shen, JK*; Li,J*. PLOSOne. 2013, 8(8):e72092.
7.Development of Novel Alkene Oxindole Derivatives As Orally Efficacious AMP-Activated Protein Kinase Activators. Yu ,LF; Li,YY; Su,MB; Zhang,M; Zhang,W; Zhang,LN; Pang,T; Zhang,RT; Liu,B; Li,JY; Li,J*; Nan,FJ*. ACS Medicinal Chemistry Letter.2013, 4(5):475-480.
8.Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice. Zhang,LN; Zhou,HY; Fu,YY; Li,YY; Wu, F; Gu,M; Wu,LY; Xia,CM; Dong,TC; Li,JY*; Shen,JK*; Li,J*; Diabetes.2013, 62:1297-1307.
9.Azoxystrobin, a Mitochondrial Complex III Qosite Inhibitor,Exerts Beneficial Metabolic Effects in Vivo and in Vitro. Gao ,AH; Fu ,YY; Zhang,KZ; Zhang,M; Jiang,HW; Fan,LX; Nan, FJ; Yuan, CG*; Li, J; Zhou,YB*; Li,JY*. BBA - General Subjects. 2014, 1840:2212-2221.
10.Discovery, Synthesis, and Structureeactivity Relationships of 20(S)-Protopanaxadiol (PPD) Derivatives as A Novel Class of AMPKa2b1g1 Activators. Liu,JH; Chen,DK; Liu,P; He,MN; Li,J; Li,JY*; Hu,LH*. European Journal of Medicinal Chemistry.2014, 79:340-349.
11.2-(3-Benzoylthioureido)-4,5,6,7-Tetrahydrobenzo[b]Thiophene-3-Carboxylic Acid Ameliorates Metabolic Disorders in High-fat Diet-fed Mice. Zhang, J; Zhang, LN; Chen,DM;Fu,YY; Zhang,F; Yang,LL; Xia,CM; Jiang,HW; Tang,CL; Xie, ZF; Yang,F; Li, J; Tang, J; Li, JY*. Acta Pharmacology Sinica. 2015, 36(4):483-496.
12.Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes. Li, SL; Xu, HL; Cui, SC; Wu, FS; Zhang, YL; Su, MB; Gong, YH; Qiu, SB; Jiao, Q; Qin, C; Shan, JW; Zhang, M; Wang, JW; Yin, Q; Xu, MH; Liu, XF; Wang, R ; Zhu, LL; Li, J; Xu, YF; Jiang, HL; Zhao, ZJ*; Li, JY*; Li, HL*. Journal of Medicinal Chemistry. 2016, 59:6772-6790.
13.The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model. Nie, LT; Shuai, L; Zhu, MR; Liu, P; Xie, ZF; Jiang, SW; Jiang, HW; Li, J; Zhao, YM; Li, JY*; Tan, MJ*. Molecular Cellular Proteomics. 2017, 16:1324-1334.
14.Discovery of Benzofuran-3(2H)-one Derivatives as Novel DRAK2 Inhibitors that Protect Islet beta-cells from Apoptosis. Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, JP* ; Li, JY*; Yu, LF*; Yang, F*. European Journal of Medicinal Chemistry. 2017, 130:195-208
15.AMP-activated protein kinase(AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. Wu,LY; Zhang,LN; Li,BH; Duan,YN; Xie,ZF; Shuai,L; Li,J*; Li,JY*. Frontiers in Physiology. 2018,9:122.
16.Novel Substituted Pyrazolone Derivatives as AMP-Activated Protein Kinase Activators to Inhibit Lipid Synthesis and Reduce Lipid Accumulation in ob/ob Mice. Zhang, M; Xie, ZF; Zhang, RT; Chen, DK; Gu, M; Cui, SC; Zhang, YM; Zhang, XW; Yu, YY; Li, J; Nan, FJ*; Li, JY*. Acta Pharmacology Sinica. 2018, doi: 10.1038/aps.2017.186.
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