郑杰 - 中国科学院上海药物研究所 -

个人简介

教育经历 2010/08–2015/06 南洋理工大学博士 2006/08–2010/06 中国药科大学学士工作经历： 2019/1–至今课题组长，研究员，中国科学院上海药物研究所 2015/7–2019/1 博士后，分子医学院 , 美国斯克瑞普斯研究所

研究领域

基于生物大分子氢氘交换质谱（蛋白质动力学）、交联质谱、组学技术的开发以及应用；并结合分子生物学、生物化学、生物物理学手段交叉解决由蛋白质（酶）的动力学异常变化所导致的重大疾病的发生机制，包括天然免疫病原相关模式识别受体的信号识别机制，由临床检测基因突变导致的自身免疫疾病发生机制等生物学热点问题，为抗感染药物和治疗性抗体的设计，以及自身免疫病、炎性疾病以及肿瘤的防治和治疗提供临床参考。目前，美国多家大型制药企业（包括辉瑞、礼来、默克、勃林格、百时美施贵宝、武田制药等）都已经搭建了氢氘交换质谱平台，证明了该技术在药物发现、抗原抗体表位定位筛选、单克隆抗体偶联药物研究等领域的巨大应用前景

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Zheng J, Strutzenberg ST, Bruce Pascal BD, and Griffin PR. Protein dynamics and conformational changes explored by Hydrogen/deuterium exchange Mass spectrometry (In press). Current Opinion of Structure Biology. 2.Zheng J*#, Wang C#, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J*, Griffin PR*. HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity. Nature communications. 2018; 9(1):5366. 3.Zheng J#, Corzo C#, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Structure. 2018; 26(11):1431-1439.e6. 4.Zheng J#, Yamada Y#, Fung TS#, Huang M, Chia R, Liu DX. Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture. Virology. 2018; 513:65-74. 5.Zheng J#, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR. HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nature communications. 2017; 8(1): 923. 6.Zheng J#, Yong HY, Panutdaporn N, Liu C, Tang K, Luo D*. High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5. Nucleic acids research. 2015; 43(2):1216-30. 7.Zheng J#, Tan BH, Sugrue R, Tang K*. Current approaches on viral infection: proteomics and functional validations. Frontiers in microbiology. 2012; 3:393. 8.Zheng J#, Sugrue RJ, Tang K*. Mass spectrometry based proteomic studies on viruses and hosts--a review. Analytica chimica acta. 2011; 702(2):149-59.