邱宏 - 中国科学院上海药物研究所 -

个人简介

教育经历 1999.9-2003.7 广州中医药大学，学士 2004.8-2010.6 中国科学院上海药物研究所，博士工作经历 2010.6-2017.6 佐治亚大学复杂碳水化合物研究中心，博士后 2017.7-2018.12 佐治亚大学复杂碳水化合物研究中心，Senior Research Associate 2019.1-现在中国科学院上海药物研究所，研究员，课题组长

研究领域

糖及糖复合物的结构与功能和以此为基础的新型诊疗手段的开发和应用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Qiu H, Shi SS, Yue J, Xin M, Nairn AV, Lin L, Liu X, Li G, Archer-hartmann SA, Dela Rosa M, Galizzi M, Wang S, Zhang F, Azadi P, van Kuppevelt TH, Cardoso WV, Kimata K, Ai X, Moremen KW, Esko JD, Linhardt RJ, Wang L (2018). A mutant cell library for systematic analysis of heparan sulfate structure-function relationships. Nature Methods. 15（11）889-899. 2. Qiu H, Shi S, Wang S, Peng H, Ding S, Wang L (2018). Proteomic profiling exosomes from vascular smooth muscle cells. Proteomics Clinical Applications. 2018 Apr 24:e1700097. 3. Thieker DF, Xu Y, Chapla D, Nora C, Qiu H, Felix T, Wang L, Moremen KW, Liu J, Esko JD, Woods RJ. Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase. Scientific Reports. 2018 Aug 7;8(1):11832. 4. Zhao W, Zhu T, Cheng R, Liu Y, He J, Qiu H, Wang L, Nagy T, Querec TD, Unger ER, Mao L (2016). Label-Free and Continuous-Flow Ferrohydrodynamic Separation of Hela Cells and Blood Cells in Biocompatible Ferrofluids. Advanced Functional Materials. 26(22):3990-3998. 5. Guo C, Fan X, Qiu H, Xiao W, Wang L, Xu B (2015). High-resolution probing heparan sulfate-antithrombin interaction on single endothelial cell surface: Single-molecule AFM studies. Physical Chemistry Chemical Physics. 17(30): 13301-13306. 6. Qiu H, Xiao WY, Yue, JW, Wang L (2015). Heparan sulfate regulates slit3 induced endothelial cell migration. Methods in Molecular Biology. 1229:549-555. 7. Xiao F, Qiu H, Cui HX, Ni XY, Li J, Liao WF, Lu LN, Ding K (2015). MicroRNA-885-3p inhibits growth of xenografted colon cancer HT-29 cells by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. Oncogene. 34(15):1968-1978. 8. Zhang B, Xiao WY, Qiu H, Wang L et al. (2014) Congenital-Diaphragmatic-Hernia Results from Disruption of Slit3-Robo4-Heparan Sulfate Signaling-elicited Developmental Angiogenesis. Journal of Clinical Investigation. 124(1):209-221 9. Qiu H, Jiang J, Liu M, Huang X, Ding SJ, Wang L (2013). Quantitative Phosphoproteomics Reveals Broad Regulatory Roles of Heparan Sulfate on Endothelial Signaling. Molecular Cellular Proteomics. 12(8):2160-2173 10. Xiao F, Qiu H, Zhou L, Shen X, Yang L, Ding K (2013). WSS25 inhibits Dicer, downregulating microRNA-210 which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology. 23(5):524-535. 11. Zhang S, Condac E, Qiu H, Jiang J, Gutierrez-Sanchez G, Bergmann C, Handel T, Wang L (2012). Heparin-Induced Leukocytosis Requires 6-O-Sulfation and is Caused by Blockade of Selectin- and CXCL12-Mediated Leukocyte Trafficking in Mice. Journal of Biological Chemistry. 287(8):5542-5553. 12. Xu YX, Dong Q, Qiu H, Ma CW, Ding K (2011). A homogalacturonan from the radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived therefrom. Carbohydrate Research. 346(13):1930-1936. 13. Xu YX, Dong Q, Qiu H, Ding K (2010). Structure elucidation of an arabinogalactan from Platycodon grandiflorum roots and anti-angiogenic activity of its sulfated derivatives. Biomacromolecules. 11(10): 2558-2566. 14. Qiu H, Yang B, Pei ZC, Zhang Z, Ding K. (2010). WSS25 repressed hepatocarcinoma growth through disrupting tumor angiogenesis via blocking the BMP/Smad/Id1 signaling. Journal of Biological Chemistry. 285(42): 32638-32646. 15. Tong XK*, Qiu H* Tang W, Ding K, Zuo JP et al (2010). WSS45, a sulfated α-D-glucan from Gastrodia elata Bl., strongly interferes with Dengue 2 virus infection in vitro. Acta Pharmacologica Sinica. 31(5): 585-592. *, Co-first author. 16. Zhang Z, Wang S, Qiu H, Duan CH, Ding K, Wang ZT (2009). Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. Cancer Letters. 286(2):223-31. 17. Qiu H*, Tang W*, Tong X, Ding K, Zuo J (2007). Structure elucidation and sulfated derivatives preparation of two alpha-D-glucans from Gastrodia elata Bl. and their anti-dengue virus bioactivities. Carbohydrate Research. 342(15):2230-6. *, Co-first author.