文留青 - 中国科学院上海药物研究所 -

个人简介

文留青，获得微生物学和化学双硕士学位，化学博士学位。2019年加入上海药物所，任研究员，课题组长。主要从事糖化学生物学和糖类药物研究。以通讯作者或者共同通讯作者身份在ACS Central Science、Chemical Reviews、J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.、ACS catalysis等杂志发表多篇研究论文。获得2016年佐治亚州立大学化学系年度优秀研究生，2017年国家优秀自费留学生奖学金。回国后先后获得上海市，中科院和国家的基金支持。工作经历 2017.5–2019.8 佐治亚州立大学，博士后 2019.9至今中国科学院上海药物研究所，研究员，课题组长

研究领域

基于寡糖的药物研究和新药靶点发现

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, S; Zhang, J; Wei, F; Li, W; Li, W; Wen, L.* Facile Synthesis of Sugar Nucleotides from Common Sugars by Cascade Conversion Strategy. J. Am. Chem. Soc. 2022 (Accept). Ma, W.; Deng, Y.; Xu, Z.; Liu, X.; Chapla, D. G.; Moremen, K. W.; Wen, L.; Li, T.* Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase. J. Am. Chem. Soc. 2022, Online. Zheng, Y.; Zhang, J.; Meisner, J.; Li, W.; Luo, Y.; Wei, F.; Wen, L.* Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides. Angew. Chem. Int. Ed. 2022, 61 (20) Tian, Y.; Zhu, Q.; Sun, Z.; Geng, D.; Lin, B.; Su, X.; He, J.; Guo, M.; Xu, H.; Zhao, Y.; Qin, W.; Wang, P. G.; Wen, L.; Yi, W.* One-Step Enzymatic Labeling Reveals a Critical Role of O-GlcNAcylation in Cell-Cycle Progression and DNA Damage Response. Angew. Chem. Int. Ed. 2021, 60 (50), 26128-26135. Xu, Z.; Deng, Y.; Zhang, Z.; Ma, W.; Li, W.; Wen, L.;* Li, T.*, Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans. J. Org. Chem. 2021, 86 (15), 10819-10828. Zhang, J.; Liu, D.; Saikam, V.; Gadi, M. R.; Gibbons, C.; Fu, X.; Song, H.; Yu, J.; Kondengaden, S. M.; Wang, P. G.; Wen, L.* Machine-Driven Chemoenzymatic Synthesis of Glycopeptide. Angew. Chem. Int. Ed. 2020, 59 (45), 19825-19829. Zhang, J.; Chen, C.; Gadi, M. R.; Gibbons, C.; Guo, Y.; Cao, X.; Edmunds, G.; Wang, S.; Liu, D.; Yu, J.; Wen, L.;* Wang, P. G.,* Machine-Driven Enzymatic Oligosaccharide Synthesis by Using a Peptide Synthesizer. Angew. Chem. Int. Ed. 2018, 57 (51), 16638-16642. Wen, L. Q.*; Gadi, R. M.; Zheng, Y.; Gibbons, C.; Kondengaden, S. M.; Zhang, J. B.; Wang, P. G.* Chemoenzymatic Synthesis of Unnatural Nucleotide Sugars for Enzymatic Biorthogonal Labeling. ACS Catal. 2018, 8 (8), 7659-7666. Wen, L. Q. #*; Edmunds, G. #; Gibbons, C. #; Zhang, J. B. #; Gadi, M. R.; Zhu, H. L.; Fang, J. Q.; Liu, X. W.; Kong, Y.; Wang, P. G.* Toward Automated Enzymatic Synthesis of Oligosaccharides. 2018, Chem. Rev. 2018, 118, 17, 8151 Wen, L. Q.*; Zheng, Y.; Huang, K.; Song, J.; Wang, P. G.* A One-step Chemoenzymatic Labeling Strategy for Probing Sialylated Thomsen？Friedenreich Antigen. ACS Centra. Sci, 2018, 4, 451451 Wen, L. Q.; Zheng, Y.; Jiang, K.; Zhang, M. Z.; Kondengaden, S. M.; Li, S. S.; Huang, K.; Li, J.; Song, J.; Wang, P. G. Two-Step Chemoenzymatic Detection of N-Acetylneuraminic Acid-alpha(2-3)-Galactose Glycans. J. Am. Chem. Soc. 2016, 138, 11473. Liu, Y. P.; # Wen, L. Q.; # Li, L.; Gadi, M. R.; Guan, W. Y.; Huang, K.; Xiao, Z. Y.; Wei, M. H.; Ma, C.; Zhang, Q.; Yu, H.; Chen, X.; Wang, P. G.; Fang, J. Q. A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids. Eur. J. Org. Chem. 2016, 4315. (contribute equally) Wen, L. Q. *; Huang, K.; Zheng, Y.; Fang, J. Q.; Kondengaden, S. M.; Wang, P. G. * Two-step enzymatic synthesis of 6-deoxy-L-psicose. Tetrahedron Lett. 2016, 57, 3819. Wen, L. Q.; Huang, K.; Zheng, Y.; Liu, Y. P.; Zhu, H.; Wang, P. G. A two-step strategy for the preparation of 6-deoxy-l-sorbose. Bioorg. Med. Chem. Lett. 2016, 26, 218. Wen, L. Q.; Zheng, Y.; Li, T. H.; Wang, P. G. Enzymatic synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and its application for LPS assembly. Bioorg. Med. Chem. Lett. 2016, 26, 2825. Wen, L. Q.; Huang, K.; Liu, Y. P.; Wang, P. G. Facile Enzymatic Synthesis of Phosphorylated Ketopentoses. ACS. Catal. 2016, 6, 1649. Wen, L. Q.; Zang, L. L.; Huang, K.; Li, S. S.; Wang, R. L.; Wang, P. G. Efficient enzymatic synthesis of L-rhamnulose and L-fuculose. Bioorg. Med. Chem. Lett. 2016, 26, 969. Wen, L. Q.; Huang, K.; Wei, M. H.; Meisner, J.; Liu, Y. P.; Garner, K.; Zang, L. L.; Wang, X.; Li, X.; Fang, J. Q.; Zhang, H. C.; Wang, P. G. Facile Enzymatic Synthesis of Ketoses. Angew. Chem. Int. Ed. 2015, 54, 12654. Li, T. H.; # Wen, L. Q.; # Williams, A.; Wu, B. L.; Li, L.; Qu, J. Y.; Meisner, J.; Xiao, Z. Y.; Fang, J. Q.; Wang, P. G. Chemoenzymatic synthesis of ADP-d-glycero-beta-d-manno-heptose and study of the substrate specificity of HldE. Biorg. Med. Chem. 2014, 22, 1139.