邹卫国 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1998年本科毕业于南开大学生物化学系，2003年中科院生物化学与细胞生物学研究所获得理学博士学位。随后在美国Scripps研究所和美国哈佛大学公共卫生学院进行博士后研究(受美国白血病淋巴瘤协会资助)。2009年获选哈佛大学公共卫生学院Yerby Fellow。2012年获聘美国康纳尔大学和纽约州立大学布法罗分校Tenure Track助理教授职位。2012年8月回中科院生物化学与细胞生物学研究所工作，任研究员，研究组长，博士生导师。获得国家自然科学基金委杰出青年科学基金资助，国家科技部基础科学重大研究计划子课题负责人，中国科学院战略性先导科技专项（B类）子课题负责人，中华医学会骨科分会再生医学青年委员会组长，中华医学会骨矿盐与骨质疏松分会基础组常委，中国生物工程学会转化医学分会常委等

研究领域

1）研究间充质干细胞所受到的表观调控在骨关节炎、骨质疏松及骨损伤修复过程中的作用。 2）研究间充质干细胞的衰老与骨疾病的关联及分子基础。 3）研究机械力对于间充质干细胞功能及骨结构的调控机制。 4）研究骨损伤修复中间充质干细胞的起源、增殖及命运决定的机制

近期论文

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1.Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16. 2.Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14. 3.Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*.(*corresponding author) (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation 24, 1886–1899. 4.Dai Q, Xie F, Han Y, Ma X, Zhou S, Jiang L*, Zou W.* Wang J*.(2017)Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice. The Journal of Biological Chemistry. VOL. 292, NO. 1, pp. 196–204. 5. Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570. 6.Niu N, Xiang JF, Yang Q, Wang L, Wei Z, Chen LL, Yang L, Zou W*. (2017) RNA-binding protein SAMD4 regulates skeleton development through translational inhibition of Mig6 expression. Cell Discovery 3, 16050. 7.Niu N, Shao R, Yan G, Zou W*. (2016) Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. The Journal of Biological Chemistry VOL. 291, NO. 52, pp. 26647–26657. 8.Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J*, Zou W*, Wei W*.(2016)Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery, 2, 15044. 9.Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research, 26:699-712. 10.Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*.(2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications,7: 11149. 11.Zou, W*, Greenblatt, M.B., Brady, N., Lotinun, S., Zhai, B., de Rivera, H., Singh, A., Sun, J., Gygi, S.P., Baron, R., Glimcher, L.H., Jones, D.C.(2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. J Exp Med. 210, 1793-806. 12.Zou, W., Chen, X., Shim, J.H., Huang, Z., Brady N., Hu, D.Z, Drapp, R., Sigrist, K., Glimcher, L.H. and Jones, D.C. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13, 59–65. 13.Zou, W.*, Greenblatt, M.B.* (*co-first author), Shim, J.H., Kant, S., Zhai, B., Brady, B., Hu, D.Z., Gygi, S.P., Davis, R., Jones, D.C. and Glimcher, L.H. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J ClinInvest . 121, 4383-92. 14.Wan, L.*, Zou, W.* (*co-first author), Gao, D., Inuzuka, H., Drapp, R., Shaik, S., Eguren, M., Hu, D.Z., Malumbres, M., Glimcher L.H. and Wei W. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44, 721-33. 15.Shim, J.H, Greenblatt, M.B., Zou, W., Huang, Z., Wein, M.N., Brady N., Hu, D., Charron, J., Brodkin, H.R., Petsko, G.A., Zaller, D., Zhai, B., Gygi, S., Glimcher, L.H., Jones, D.C. （2013） Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123:4010-22. 16.Greenblatt, M.B., Shim, J.H., Zou, W., Sitara, D., Schweitzer, M., Hu, D., Lotinun, S., Sano, Y., Baron, R., Park, J.M., Arthur, S., Xie, M., Schneider, M.D., Zhai, B., Gygi, S., Davis, R., Glimcher, L.H. (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 120, 2457-73. 17.Shim J,H., Greenblatt, M.B., Xie, M., Schneider, M.D., Zou, W., Zhai, B., Gygi, S., Glimcher, L.H. (2009) TAK1 is an essential regulator of BMP ignaling in cartilage. EMBO J. 28, 2028-41. 18.Zou, W., Kim, J.H., Handidu, A., Li, X., Kim, K.I., Yan, M., Li, J., Zhang D.E. (2007). Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages. BiochemBiophys Res Commun. 356, 193-9. 19.Zou,W., Wang, J., and Zhang,D.E. (2007). Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. BiochemBiophys Res Commun., 354, 321-327. 20.Okumura, F., Zou, W., and Zhang, D.E. (2007).ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21, 255 – 260.