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Xu X#, Li H#, Xu, C*. Structural understanding of T cell receptor triggering. Cellular & Molecular Immunology, DOI: https://doi.org/10.1038/s41423-020-0367-1,2020.
Huang B, Song B, Xu C*. Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nature Metabolism, DOI: https://doi.org/10.1038/s42255-020-0174-0,2020.
Li H*, Yan C, Guo J, Xu C*. Ionic protein–lipid interactions at the plasma membrane regulate the structure and function of immunoreceptors. Advances in Immunology, 144 pp 65-85, 2019.
Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez R, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold B, Zhu C, Chen W*, Lou J*. Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Molecular Cell. 73(5):1015-1027, 2019.
Meng X#, Liu X#, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu X, Zhou P, Huang X, Wei L, Yang W, Xu C*. FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 564 (7734): 130-135, 2018.
Guo J#, Zhang Y#, Li H#, Chu H#, Wang Q, Jiang S, Li Y, Shen H, Li G*, Chen J*, Xu C*. Intramembrane ionic protein-lipid interaction regulates integrin structure and function. PLoS Biology, 16(11):e2006525, 2018.
Chen X#, Sun X#, Yang W#, Yang B#, Zhao X, Chen S, He L, Chen H, Yang C, Xiao L, Chang Z, Guo J, He J, Zhang F, Zheng F, Hu Z, Yang Z, Lou J, Zheng W, Qi H, Xu C, Zhang H, Shan H, Zhou XJ, Wang Q, Shi Y, Lai L, Li Z*, Liu W*. An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. Science. 362 (6415): 700-705, 2018.
Wang J, Yan C, Xu C, Chua B, Li P*, Chen F*. Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. Journal of Biological Chemistry. 293(50):19330-19343, 2018.
Xu C, Xie H, Guo X, Gong H, Liu L, Qi H, Xu C, Liu W*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Science Immunology, 2(17), 2017
Bietz A#, Zhu H#, Xue M, Xu C*. Cholesterol Metabolism in T Cells. Frontiers in Immunology, 8:1664, 2017
Yang W#, Pan W#, Chen S#, Trendel N#, Jiang S#, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O*, Li H*, Xu C*. Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nature Structural & Molecular Biology, 24(12), pp 1081-1092, 2017.
Wang H, Wang S, Li C, Li H, Mao Y, Liu W, Xu C*, Long D*. Probing Transient Release of Membrane-Sequestered Tyrosine-Based Signaling Motif by Solution NMR Spectroscopy. The Journal of Physical Chemistry Letters, 8(16), pp 3765-3769, 2017.
Li L#, Guo X#, Shi X#, Li C#, Wu W, Yan C, Wang H, Li H, Xu C*. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proceedings of the National Academy of Sciences of the United States of America (Plus), 114(29), pp E5891-E5899, 2017.
Guo X#, Yan C#, Li H#, Huang W#, Shi X, Huang M, Wang Y, Pan W, Cai M, Li L, Wu W, Bai Y, Zhang C, Liu Z, Wang X, Zhang F X, Tang C, Wang H, Liu W, Ouyang B, Catherine C Wong, Cao Y*, Xu C*. Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Research, 27(4), pp 505-525, 2017.
Xu L#, Xia M#, Guo J#, Sun X#, Li H, Xu C, Gu X, Zhang H, Yi J, Fang Y, Xie H, Wang J, Shen Z, Xue B, Sun Y, Meckel T, Chen Y, Hu Z, Li Z*, Xu C*, Gong H*, Liu W*. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. The Journal of Experimental Medicine, 213(12), pp 2707-2727, 2016.
Wu W, Shi X, Xu C*. Regulation of T cell signalling by membrane lipids. Nature Reviews Immunology, 16(11), pp 690-701, 2016.
Liu W*, Wang H, Xu C*. Antigen Receptor Nanoclusters:Small Units with Big Functions. Trends in Immunology, 37(10), pp 680-689, 2016.
Yang W#, Bai Y#, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang C, Chang T, Zhang T, Zhou P Song B, Liu W, Sun S, Liu X, Li B*, Xu C*. Potentiating the anti tumour response of CD8+ T cells by modulating cholesterol metabolism. Nature, 531(7596), pp 651-655, 2016.
Cui Y#, Chen X#, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X*. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. Cell Reports, 15(2), pp 256-263, 2016.
Chen X#, Pan W#, Sui Y, Li H, Shi X, Guo X, Qi H, Xu C*, Liu W*. Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Communications, 6(8552), 2015.