沈义栋 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

2002年毕业于复旦大学生命科学学院。2008年于中科院生化与细胞所获博士学位。2009年至2014年作为博士后先后在美国贝勒医学院和德国马普衰老所从事衰老机理的研究并获得欧洲分子生物学组织（EMBO）的EMBO Long-Term Fellowship资助。2014年回中科院生化与细胞所工作，担任研究员，课题组长及博士生导师

研究领域

衰老及衰老相关疾病的机理研究

近期论文

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Shen, Y., Wollam, J., Magner, D., Karalay, O., and Antebi, A. (2012). A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science 338, 1472-1476. Cao, J.*, Shen, Y.*, Zhu, L., Xu, Y., Zhou, Y., Wu, Z., Li, Y., Yan, X., and Zhu, X. (2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol 14, 697-706. Shen, Y.*, Li, N.*, Wu, S., Zhou, Y., Shan, Y., Zhang, Q., Ding, C., Yuan, Q., Zhao, F., Zeng, R., et al. (2008). Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14, 342-353. Magner, D.B., Wollam, J., Shen, Y., Hoppe, C., Li, D., Latza, C., Rottiers, V., Hutter, H., and Antebi, A. (2013). The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans. Cell Metab 18, 212-224. Heestand, B.N., Shen, Y., Liu, W., Magner, D.B., Storm, N., Meharg, C., Haberman, B., Antebi, A. (2013). Dietary Restriction Induced Longevity Is Mediated by Nuclear Receptor NHR-62 in Caenorhabditis elegans. PLoS Genet 9(7): e1003651. Wollam, J., Magner, D.B., Magomedova, L., Rass, E., Shen, Y., Rottiers, V., Habermann, B., Cummins, C.L., and Antebi, A. (2012). A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol 10, e1001305. Wollam, J., Magomedova, L., Magner, D.B., Shen, Y., Rottiers, V., Motola, D.L., Mangelsdorf, D.J., Cummins, C.L., and Antebi, A. (2011). The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell 10, 879-884. Yan, X., Shen, Y., and Zhu, X. (2010). Live show of Rho GTPases in cell migration. J Mol Cell Biol 2, 68-69. Zhang, Q., Wang, F., Cao, J., Shen, Y., Huang, Q., Bao, L., and Zhu, X. (2009). Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic 10, 1337-1349. Yan, X., Li, F., Liang, Y., Shen, Y., Zhao, X., Huang, Q., and Zhu, X. (2003). Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol Cell Biol 23, 1239-1250.