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个人简介

2007年毕业于武汉大学生命科学与技术基地班,获理学学士学位。2012年毕业于武汉大学生命科学学院生物化学与分子生物学专业,获理学博士学位。2012年至2019年在美国俄亥俄州立大学从事生物化学、生物物理方向的博士后研究。2019年8月加入中科院生物化学与细胞生物学研究所,任研究员、研究组长、博士生导师

研究领域

①如何准确修复DNA损伤并维持基因组稳定,对于细胞存活、防止癌变起着至关重要的作用。因而,与此相关的分子机制研究是DNA修复生物学的核心内容,对肿瘤诊治、延缓衰老、抗肿瘤药物的设计具有重要的理论指导意义。本课题组针对DNA损伤修复、核小体DNA修复和复制等生命活动中的关键科学问题开展深入系统的研究,观测蛋白质及其复合物在以上过程中的装配规律、构象变化和相互作用,解析这些重要生命过程的分子机制。②许多RNA结合蛋白参与了大量RNA代谢过程,包括 RNA的剪接、转录、转运、翻译、降解等,与动物生殖、癌症发生以及病原微生物致病密切相关,虽然部分相关蛋白的结构已经得到解析,许多关键的核心问题却依然未有答案

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Liu, J.*, Lee, R.*, Britton, M. B.* et al. MutL Sliding Clamps Coordinate Exonuclease-Independent Escherichia coli Mismatch Repair. Nat Commun 10, 5294 (2019) (*Equal contribution). Hanne, J., Britton, M. B., Park, J., Liu, J. et al. MutS homolog sliding clamps shield the DNA from binding proteins. J Biol Chem 293, 14285-14294 (2018). Liu, J. et al. Stochastic Processes and Component Plasticity Governing DNA Mismatch Repair. J Mol Biol 22, 4456-4468 (2018). Liu, J.*, Hanne, J.* et al. Cascading MutS and MutL Sliding Clamps Control DNA Diffusion to Activate Mismatch Repair. Nature 539 (7630), 583-587 (2016). (*Equal contribution) Senavirathne, G.*; Liu, J.*, Lopez, M. A. et al. Widespread Nuclease Contamination in Commonly Used Oxygen-Scavenging Systems. Nat Methods 12, 901-2 (2015). (*Equal contribution) Liu, J. et al. An Efficient Site-Specific Method for Irreversible Covalent Labeling of Proteins with a Fluorophore. Sci Rep 5, 16883 (2015). Liu, J.*, Xiao, S.*, Hao, Y.H. & Tan, Z. Strand-Biased Formation of G-Quadruplexes in DNA Duplexes Transcribed with T7 RNA Polymerase. Angew Chem Int Ed Engl 54, 8992-6 (2015). (*Equal contribution) Zheng, K. W., Wu, R. Y., He, Y. D., Xiao, S., Zhang, J. Y., Liu, J., Hao, Y. H., Tan, Z. A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site. Nucleic Acids Res 42, 10832-44 (2014). Zheng, K.W., Xiao, S., Liu, J., Zhang, J. Y., Hao, Y. H., Tan, Z. Co-transcriptional formation of DNA:RNA hybrid G-quadruplex and potential function as constitutional cis element for transcription control. Nucleic Acids Res 41, 5533-41 (2013). Xue, Y.*, Liu, J.*, Zheng, K. W., Kan, Z. Y., Hao, Y. H., Tan, Z. Kinetic and Thermodynamic Control of G-quadruplex Folding. Angew Chem Int Ed Engl 50, 8046-50 (2011). (*Equal contribution) Wang, Q., Liu, J., Chen, Z., Zheng, K. W., Chen, C. Y., Hao, Y. H., Tan, Z. G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase. Nucleic Acids Res 2011, 39 (14), 6229-37. Chen, C. Y., Wang, Q., Liu, J., Hao, Y. H., Tan, Z. Contribution of telomere G-quadruplex stabilization to the inhibition of telomerase-mediated telomere extension by chemical ligands. J Am Chem Soc 2011, 133 (38), 15036-44. Liu, J., Chen, C. Y., Xue, Y., Hao, Y. H., Tan, Z. G-quadruplex Hinders Translocation of BLM Helicase on DNA: a real-time fluorescence spectroscopic unwinding study and comparison with duplex substrates. J Am Chem Soc 132, 10521-7 (2010).

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