个人简介
2005年本科毕业于复旦大学，2011年博士毕业于中科院上海生命科学院生化细胞所。2012年以博士后身份先后在西南医学中心（UT Southwestern Medical Center）和克利夫兰诊所（Cleveland Clinic Foundation）Nima Sharifi实验室从事前列腺癌相关研究。2012年获美国国防部DOD PCRP Fellowship；2015年获得Prostate Cancer Foundation Young Investigator Award。2016年11月加入中科院上海生科院生化与细胞所，任研究员、研究组长
研究领域
1. 固醇激素代谢与前列腺癌治疗耐受；
2. 前列腺癌治疗的新靶点和新药物的发现；
3. 药物代谢及其在临床上的应用；
4. 固醇激素代谢在乳腺癌、卵巢癌中的研究
近期论文
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（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Xiaomei Gao*, Charles Dai*, Shengsong Huang*, Jingjie Tang*, Guoyuan Chen, Jianneng Li, Ziqi Zhu, Xuyou Zhu, Shuirong Zhou, Yuanyuan Gao, Zemin Hou, Zijun Fang, Chengdang Xu, Jianyang Wang, Denglong Wu#, Nima Sharifi#, Zhenfei Li#. Functional silencing of HSD17B2 in prostate cancer promotes disease progression. Clin Cancer Res. 2019, 25(4): 1291~1301.
Zhenfei Li, Mohammad Alyammani, Jianneng Li, Kevin Rogacki, Mohamed Abazeed, Sunil Upadhyay, Steven P. Balk, Mary-Ellen Taplin, Richard J. Auchus, Nima Sharifi. Redirecting abiraterone metabolism to biochemically fine tune prostate cancer therapy. Nature. 533, 547-551 (2016).
Mohammad Alyamani, Zhenfei Li, Sunil K Upadhyay, David J Anderson, Richard J Auchus, Nima Sharifi. Development and validation of a novel LC–MS/MS method for simultaneous determination of abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. J Steroid Biochem Mol Biol, doi: 10.1016. (2016).
Zhenfei Li, Andrew Bishop, Mohammad Alyamani, Jorge A. Garcia, Robert Dreicer, Dustin Bunch, Jiayan Liu, Sunil K. Upadhyay, Richard J. Auchus, Nima Sharifi. Conversion of abiraterone to D4A drives antitumor activity in prostate cancer. Nature. 523, 347-351 (2015).
Hamid Emamekhoo, Zhenfei Li and Nima Sharifi. Clinical significance of D4A in prostate cancer therapy with abiraterone. Cell cycle. 14, 3213-3214 (2015).
Cong Fei, Zhenfei Li, Chen Li, Yuelei Chen, Zhangcheng Chen, Xiaoli He, Li Mao, XinWang, Rong Zeng and Lin Li. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/beta-catenin signaling. Mol Cell Biol. 33, 4095-105 (2013).
Zhenfei Li*, Fen Nie*, Sheng Wang, Lin Li. Histone 4 Lys-20 Mono-Methylation by SET8 Mediates Wnt Target Gene Activation. Proc Natl Acad Sci USA. 108, 3116-23 (2011). (*co-first author)
Zhihui Xie*, Yongfeng Chen*, Zhenfei Li, Ge Bai, Yue Zhu, Ye-Guang Chen, Francois Guillemot, Lin Li, Naihe Jing. Smad6 Inhibits Wnt/β-catenin Pathway by Recruiting CtBP to Promote Neuronal Differentiation. Proc Natl Acad Sci USA. 108, 12119-24 (2011). (*co-first author)
Meng Li, He Wang, Tao Huang, Jiyong Wang, Yu Ding, Zhenfei Li, Jinkuo Zhang and Lin Li. TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J Biol Chem. 285, 13397-13404 (2010).
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