当前位置: X-MOL首页全球导师 国内导师 › 李林

个人简介

1983年毕业于南京大学生物系生物化学专业获学士学位,1989年在中国科学院上海生物化学研究所研究生毕业获博士学位,1990至1992年在美国纽约州立大学石溪分校生理与生物物理系做博士后研究,1992年回上海生化所工作至今。1991年被上海生化所聘为副研究员,1993年晋升为研究员,2011年被增选为中国科学院院士。2000年至2005年担任生物化学与细胞生物学研究所(生化与细胞所)学术委员会主任,2002至2004年担任生化与细胞所常务副所长,2004至2009年担任所长,2008至2013年担任中国科学院上海生命科学研究院副院长,2013年至今担任院长。此外, 2006年至今担任分子生物学国家重点实验室主任,2011年至今再次担任生化与细胞所学术委员会主任。1995年获得国家杰出青年科学基金的资助,1996年获香港求是基金会“杰出青年学者奖”。1999至2003年主持国家自然科学基金重大项目“蛋白质组及蛋白质结构动态变化与功能关系”,2002至2008年作为首席科学家主持国家重点基础研究发展规划 (973计划)“炎症的细胞信号转导网络及其调控机制”项目,2010至2014年作为首席科学家主持国家重大科学研究计划“细胞生长调控的重要蛋白质群的功能与作用机制”项目,2006至2011年作为学术带头人主持国家基金委创新群体“细胞命运决定的分子网络”项目。目前担任中国生物化学与分子生物学会理事长。2008至2013担任《JBC》编委,目前担任《Cell Research》、《Cell Discovery》、《JMCB》、《ABBS》等期刊编委或编辑等。 

研究领域

我们实验室通过研究Wnt信号转导的蛋白质相互作用网络及其调控的分子机制,着眼于新分子、新机制及新功能的发现,以期更深入了解胚胎发育、癌症发生等过程中Wnt信号所发挥的生物学功能

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Chao Wang, Wenxiang Zhang, Meng-Xin Yin, Lianxin Hu, Peixue Li, Jiajun Xu, Hongling Huang, Shimin Wang, Yi Lu, Wenqing Wu, Margaret S. Ho, Lin Li, Yun Zhao, and Lei Zhang* (2015) Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis. Nature Communications, in press. Jia Shen, Xiangpeng Sheng, ZeNan Chang, Qian Wu, Sheng Wang, Zongliang Xuan, Dan Li, Yalan Wu, Yongjia Shang, Xiangtao Kong, Long Yu, Lin Li, Kangchen Ruan, Hongyu Hu, Ying Huang, Lijian Hui, Dong Xie, Fudi Wang, and Ronggui Hu* (2014) Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell Reports, 7, 1-14. Zhengzhao Liu, Peng Chen, Hong Gao, Yu Gu, Jiao Yang, Hong Peng, Xingxing Xu, Haifeng Wang, Meiqiang Yang, Xiaoying Liu, Libin Fan, Shiyao Chen, Jian Zhou, Yihong Sun, Kangchen Ruan, Shuqun Cheng, Masaaki Komatsu, Eileen White, Lin Li, Hongbin Ji, Daniel Finley, Ronggui Hu* (2014) Ubiquitylation of autophagy receptor optineurin. Cancer Cell, 26, 106-120. Xiaomin Song, Sheng Wang, and Lin Li* (2014) New insights into the regulation of Axin function in canonical Wnt signaling pathway. Protein & Cell, 5, 186-193 Ying-ying Jia, Fen Nie, Ai-ying Du, Zhang-cheng Chen, Yuan-bo Qin, Tao Huang, Xiao-min Song, and Lin Li* (2014) Thymine DNA glycosylase promotes transactivation of b-catenin/TCFs by cooperating with CBP. J. Mol. Cell Biol., 6, 231-239 Haofei Miao, Yingying Jia, Sichun Xie, Xin Wang, Jianfei Zhao, Youjun Chu, Zhilei Zhou, Zhubing Shi, Xiaomin Song*, and Lin Li* (2014) Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling. J. Biol. Chem., 289, 34104–34113 Cong Fei*, Xiaoli He, Sichun Xie, Haofei Miao, Zhilei Zhou, and Lin Li* (2014) Smurf1-mediated Axin ubiquitination requires Smurf1 C2 domain and is cell-cycle dependent. J. Biol. Chem., 289, 14170-14177 Sheng Wang, Junlin Yin, Duozhi Chen, Fen Nie, Xiaomin Song, Cong Fei, Haofei Miao, Changbin Jing, Wenjing Ma, Lei Wang, Sichun Xie, Chen Li, Rong Zeng, Weijun Pan, Xiaojiang Hao*, and Lin Li* (2013) Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nature Chem. Biol., 9, 579-585. Chun-Xiao Song, Keith E. Szulwach, Qing Dai, Ye Fu, Shi-Qing Mao, Li Lin, Craig Street, Yujing Li, Mickael Poidevin, Hao Wu, Juan Gao, Peng Liu, Lin Li, Guo-Liang Xu, Peng Jin, and Chuan He (2013) Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell, 153, 678-691. Cong Fei, Zhenfei Li, Chen Li, Yuelei Chen, Zhangcheng Chen, Xiaoli He, Li Mao, Xin Wang, Rong Zeng, and Lin Li* (2013) Smurf1-mediated Lys29-linked non-proteolytic poly-ubiquitination of Axin negatively regulates Wnt/β-catenin signaling. Mol. Cell Biol., 33, 4095-4105. Wei Wei, Meng Li, Jiyong Wang, Fen Nie and Lin Li* (2012) The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein. Mol. Cell Biol., 32, 3903-3912. Yu-Fei He, Bin-Zhong Li, Zheng Li, Peng Liu, Yang Wang, Qingyu Tang, Jianping Ding, Yingying Jia, Zhangcheng Chen, Lin Li, Yan Sun, Xiuxue Li, Qing Dai, Chun-Xiao Song, Kangling Zhang, Chuan He, and Guo-Liang Xu (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science, 333, 1303-1307. Tao Huang, Zhihui Xie, Jiyong Wang, Meng Li, Naihe Jing, and Lin Li* (2011) Nuclear Factor of Activated T Cell (NFAT) Proteins repress canonical Wnt signaling via its interaction with dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation. J. Biol. Chem., 286, 37399-37405. Wenwen Tang, Yong Zhang, Wenwen Xu, T. Kendall Harden, John Sondek, Le Sun, Lin Li, and Dianqing Wu* (2011) A PLCb/PI3Kg-GSK3 signaling pathway regulates cofilin phosphatase Slingshot2 and neutrophil polarization and chemotaxis. Dev. Cell, 21, 1038-1050. Zhihui Xie, Yongfeng Chen, Zhenfei Li, Ge Bai, Yue Zhu, Rui Yan, Fangzhi Tan, Ye-Guang Chen, Francois Guillemot, Lin Li, and Naihe Jing (2011) Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/b-catenin pathway. Proc. Natl. Acad. Sci. USA, 108, 12119-12124. Zhenfei Li, Fen Nie, Sheng Wang, and Lin Li* (2011) Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc. Natl. Acad. Sci. USA, 108, 3116-3123. Wei Wang, Haiyang Liu, Sheng Wang, Xiaojiang Hao*, and Lin Li* (2011) A diterpenoid derivative 15-oxospiramilactone inhibits Wnt/b-catenin signaling and colon cancer cell tumorigenesis. Cell Res., 21, 730-740. Meng Li, He Wang, Tao Huang, Jiyong Wang, Yu Ding, Zhenfei Li, Jinkuo Zhang, and Lin Li* (2010) TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling. J. Biol. Chem., 285, 13397-13404. Ning Deng, Yanger Ye, Wei Wang, and Lin Li* (2010) Dishevelled interacts with p65 and acts as a repressor of NF-kB-mediated transcription. Cell Res., 20, 1117-1127. Bianhong Zhang, Meng Li, Liang Chen, Kai Yang, Yufei Shan, Lianhui Zhu, Shaogang Sun, and Lin Li*, and Chen Wang* (2009) The TAK1-JNK cascade is required for IRF3 function in the innate immune response. Cell Res., 19, 412-428.

推荐链接
down
wechat
bug