姜海 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

2011年-至今：中国科学院上海生命科学研究院生物化学与细胞生物学研究所，研究员，研究组长 2007-2011年：美国麻省理工学院癌症研究中心，博士后 2000-2006年：美国西北大学医学院，博士 1996-2000年：北京大学生命科学学院，学士

研究领域

癌症的个体化治疗，癌症基因的功能与调控

近期论文

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Ding H, Zhao J, Zhang Y, Yu J, Liu M, Li X, Xu L, Lin M, Liu C, He Z, Chen S, Jiang H. Systematic analysis of drug vulnerabilities conferred by tumor suppressor loss. (2019) Cell Reports 27,3331-3344. Li X, Zhang Y, Zheng L, Liu M, Chen CD, Jiang H. UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma. (2018) Nature Communications. 9(1):2720 Liu C, Ding H, Li X, Pallasch CP, Hong L, Guo D, Chen Y, Wang D, Wang W, Wang Y*, Hemann MT*, Jiang H*. A DNA/HDAC dual-targeting drug with significantly enhanced anticancer potency. (2015) EMBO Molecular Medicine, 7(4):438-49 (*Corresponding author) Wang N, Ding H, Liu H, Li X, Wei L, Yu J, Liu M, Ying M, Gao W, Jiang H* , Wang Y＊. A novel recurrent CHEK2 Y390C mutation identified in high risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk. (2015) Oncogene, 34(40):5198-205 (*Corresponding author) Wu J#, Jiang H#, Luo S#, , Zhang M, Zhang Y, Sun F, Huang S and Li H. Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. (2013) Cell Res, 23(5):691-704. (#equal contribution) Jiang H, Pritchard JR, Williams RT, Lauffenburger DA, Hemann MT. A mammalian functional-genetic approach to characterizing cancer therapeutics. (2011) Nat Chem Biol. 7(2):92-100. Reinhardt HC#, Jiang H#, Hemann MT and Yaffe MB. Exploiting synthetic lethal interactions for targeted cancer therapy. (2009) Cell Cycle 8(19) :3112-9. (#equal contribution) Jiang H#, Reinhardt HC#, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. The combined status of ATM and p53 link tumor development with therapeutic response. (2009) Genes Dev. 23(16):1895-909. (#equal contribution) Jiang H#, Wu J#，He C, Yang W, Li H. Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation. (2009) Cell Res. 19(4):458-68. (#equal contribution) Jiang H, Luo S, Li H. Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. (2005) J Biol Chem. 280(21):20651-9