高影 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

2000年毕业于河南大学物理系，获理学学士学位。2006年毕业于日本综合研究大学院大学/日本国立自然科学研究机构，获生物物理专业博士学位。2007年至2013年先后在美国爱因斯坦医学院、耶鲁大学从事博士后研究工作，并被晋身为研究科学家。2014年任上海生科院生化与细胞所研究员，研究组长，博士生导师；兼任上海科技大学特聘教授，研究生导师

研究领域

单分子技术的生物应用；蛋白质与核酸相互作用机制，马达蛋白工作机制解析

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jiao J., Rebane A., Ma L., Gao Y., Zhang Y., Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition. Proc. Natl. Acad. Sci. USA., 2015, 112(22): E2855–E2864 Ma L, Rebane A., Yang G., Xi Z., Kang Y., Gao Y., Zhang Y., Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis. eLife, 2015, 10.7554:09580 Gao Y., Zorman S., Gundersen G., Xi Z., Ma L., Sirinakis G., Rothman J. E., Zhang Y., Single SNARE Complexes Zipper in Three Distinct Stages. Science, 337,1340-1343,2012. (Faculty 1000 recommended paper, Science perspective reviewed paper, Science Signaling Editor’s choice) Sirinakis G., Ren Y., Gao Y., Xi Z., Zhang Y., Combined versatile high-resolution optical tweezers and single-molecule fluorescence microscopy. Rev. Sci. Instrum. 83, 093708, 2012. Zhang Y, Sirinakis G., Gundersen G., Xi Z., Gao Y., “DNA Translocation of atp-Dependent Chromatin Remodelling Factors Revealed by High-Resolution Optical Tweezers” (2012) Methods in Enzymology Vol 513: Nucleosomes, Histones & Chromatin Part B, 1st ed., Oxford uk Xi Z., Gao Y., Sirinakis G., Guo H., Zhang Y., Single-molecule Observation of Helix Staggering, Sliding, and Coiled Coil Misfolding. Proc. Natl. Acad. Sci. USA, 109 (15) 5711-5716, 2012 Gao Y., Sirinakis G., Zhang Y., Highly Anisotropic Stability and Folding Kinetics of a Single Coiled Coil Protein under Mechanical Tension. J. Am. Chem. Soc. 133, 12749–12757, 2011. Sirinakis G., Clapierc C.R., Gao Y., Viswanathanc R., Cairnsc B.R., Zhang, Y., The RSC Chromatin Remodeling ATPase can Translocate DNA with High Force and Small Step Size. EMBO J. 30, 2364-2372, 2011. Shang Z., Gao Y., Jia T., Mo Y., Vibrational modes study of thymine on the surface of copper electrode using SERS-measurement and the DFT method. J Mol Struct, 930(1-3), 60-64, 2009. Sato A., Gao Y., Kitagawa T. and Mizutani Y., Primary Protein Response after Ligand Photodissociation in Carbonmonoxy Myoglobin. Proc. Natl. Acad. Sci. USA. 104, 9627-9632, 2007. Gao Y., El-Mashtoly S. F., Pal B., Hayashi T., Harada K., Kitagawa T., Pathway of Information Transmission from Heme to Protein upon Ligand Binding/Dissociation in Myoglobin Revealed by UV Resonance Raman Spectroscopy. J Biol Chem. 281(34), 24637-24646, 2006. Gao Y., Koyama M, El-Mashtoly S. F., Hayashi T., Harada K., Mizutani Y. and Kitagawa T., Time-resolved Raman Evidence for Energy “Funneling” through Propionate Side Chains in Heme “Cooling” upon Photolysis of Carbonmonoxy Myoglobin. Chem. Phys. Lett. 429(1-3), 239-243, 2006.