鲍岚 - 中国科学院上海生物化学与细胞生物研究所 -

个人简介

1985年毕业于第四军医大学空军医学系，1988年在该校获硕士学位。1993年在瑞典卡罗琳斯卡医学院神经科学系进修一年。1996年任第四军医大学空军医学系副教授，1999年获医学博士学位。1999年11月在中国科学院神经科学研究所感觉系统研究组任副研究员，2002年10月获中科院上海生命科学研究院“优秀青年人才计划”，同年任该组合作课题组长。获2003年度国家自然科学杰出青年基金资助。现任中科院生化细胞所课题组长、研究员、博士生导师。曾获军队科技进步一等奖一项、二等奖一项，国家科技进步三等奖一项，上海市科技进步二等奖一项

研究领域

神经细胞蛋白质运输机制与功能

近期论文

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Wang B and Bao L*. (2017) Axonal microRNAs: localization, function and regulatory mechanism during axon development. J. Mol. Cell Biol., 9: 82-90. Yang L, Dong F, Yang Q, Yang PF, Wu R, Wu QF, Wu D, Li CL, Zhong YQ, Lu YJ, Cheng X, Xu FQ, Chen L, Bao L and Zhang X. (2017) FGF13 selectively regulates heat nociception by interacting with Nav1.7. Neuron, 93: 806-821. Wang B, Pan L, Wei M, Wang Q, Liu WW, Wang N, Jiang XY, Zhang X and Bao L*. (2015) FMRP-mediated axonal delivery of miR-181d regulates axon elongation by locally targeting Map1b and Calm1. Cell Reports, 13: 1-14. Chen XQ, Zhu JX, Wang Y, Zhang X and Bao L*. (2014) CaMKIIα and caveolin-1 cooperate to drive ATP-induced membrane delivery of the P2X3 receptor. J. Mol. Cell Biol., 6: 140-153. Su YY, Ye M, Li L, Liu C, Pan J, Liu WW, Jiang Y, Jiang XY, Zhang X, Shu Y and Bao L*. (2013) KIF5B promotes the forward transport and axonal function of the voltage-gated sodium channel Nav1.8. J. Neurosci., 33: 17884-17896. Han QJ, Gao NN, Ma GQ, Zhang ZN, Yu WH, Pan J, Wang Q, Zhang X and Bao L*. (2013) IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF-β/Smad signaling. J. Cell Sci., 126: 542-553. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L*. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L*. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696. Wu QF, Yang L, Li S, Wang Q, Yuan XB, Gao X, Bao L and Zhang X. (2012) Fibroblast growth factor 13 is a microtubule-stabilizing protein regulating neuronal polarization and migration. Cell, 149:1549-1564. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L* and Zhang X*. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131. Li Q, Su YY, Wang H, Li L, Wang Q and Bao L*. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987. Wang HB, Zhao B, Zhong YQ, Li KC, Li ZY, Wang Q, Lu YJ, Zhang ZN, He SQ, Zheng HC, Wu SX, Hökfelt TGM*, Bao L*, and Zhang X*. (2010) Coexpression of δ- and µ-opioid receptors in nociceptive sensory neurons. Proc Natl Acad Sci U S A., 107: 13117-13122 Liu C, Li Q, Su YY and Bao L* (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417. Zhang X*, Bao L* and Ma GQ (2010) Sorting of neuropeptides and neuropeptide receptors into secretory pathways. Progress in Neurobiology, 90: 276-283. (Review) Ma GQ, Wang B, Wang HB, Wang Q and Bao L* (2008) Short elements with charged amino acids form clusters to sort protachykinin into large dense-core vesicles. Traffic, 9: 2165–2179. Zhang ZN, Li Q, Liu C, Wang HB, Wang Q and Bao L* (2008) Voltage-gated sodium channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit. J. Cell Sci. 121: 3243-3252