尤进茂 - 曲阜师范大学 - 化学与化工学院

研究领域

本人长期从事色谱-质谱分析新试剂、新材料、新方法的开发研究，利用开发的新方法对食品、环境、药物、生命等领域的分析工作中，解决当前各领域的重大问题，具体主要开展以下三个方面的工作。 1. 特色药用植物资源开发与保护研究：采用先进的现代分析测试技术对我国特色药用植物进行指纹图谱分析，阐明外界条件对植物形态结构、化学成分和遗传特性的影响，及植物对环境条件的适应和改造作用，为特色药用植物资源开发与保护提供理论依据。 2. 环境有机污染物的高灵敏检测与监控研究。从分发挥新材料的优势，在样品前处理，色谱分离和质谱鉴定等方面研究如多环芳烃 ,多氯联苯 ,以及杀虫剂等持久性有机污染物分析定量新技术，提高方法的灵敏度、准确度和分析通量。 3.蛋白质组学和代谢组学分析新方法及生物标志物筛选研究工作。通过开发新型等重同位素标记试剂，建立组学分析新方法，将新方法用于癌症患者体液、组织、细胞等样品的分析，以期筛选出灵敏特异的肿瘤标志蛋白，提高癌症的诊疗水平。

近期论文

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1.S.J. Zhang, J.M. You*, S.J. Ning, C.H. Song, and Y.R. Suo, Analysis of estrogenic compounds in environmental and biological samples by liquid chromatography-tandem mass spectrometry with stable isotope-coded ionization-enhancing reagent. Journal of Chromatography A 1280 (2013) 84-91. 2.S.J. Zhang, J.M. You*, G.Y. Zhou, C.L. Li, and Y.R. Suo, Analysis of free fatty acids in Notopterygium forbesii Boiss by a novel HPLC method with fluorescence detection. Talanta 98 (2012) 95-100. 3.S.J. Zhang, J.M. You, Z.W. Sun, C.H. Song, S.J. Ning, C.S. Zhao, and Y.R. Suo, A sensitive method for extraction and determination of endocrine-disrupting compounds from wastewater using 10-ethyl-acridone-2-sulfonyl chloride as pre-column labeling reagent by high-performance liquid chromatography with fluorescence detection. Microchemical Journal 103 (2012) 90-96. 4.S.J. Zhang, J.M. You*, C.H. Song, G. Chen, and Y.R. Suo, Purification and determination of bisphenol A and alkylphenol in river sediments by high performance liquid chromatography with fluorescence detection. Analytical Methods 4 (2012) 4030-4036. 5.H.Y. Sun, J.M. You*, M.H. Yang, and F.L. Qu, Synthesis of Pt/Fe3O4-CeO2 catalyst with improved electrocatalytic activity for methanol oxidation. Journal of Power Sources 205 (2012) 231-234. 6.G. Chen, J. Li, S.J. Zhang, C.H. Song, G.L. Li, Z.W. Sun, Y.R. Suo, and J.M. You*, A sensitive and efficient method to systematically detect two biophenols in medicinal herb, herbal products and rat plasma based on thorough study of derivatization and its convenient application to pharmacokinetics with semi-automated device. Journal of Chromatography A 1249 (2012) 190-200. 7.G. Chen, J. Li, C.H. Song, Y.R. Suo, and J.M. You*, A sensitive and efficient method for simultaneous trace detection and identification of triterpene acids and its application to pharmacokinetic study. Talanta 98 (2012) 101-111. 8.Z.W. Sun, J.M. You*, C.H. Song, and L. Xia, Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro 9,10-d imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS. Talanta 85 (2011) 1088-1099. 9.Z.W. Sun, J.M. You, G.L. Li, X.E. Zhao, Y.R. Suo, and X. Wang, Determination of amino acids in rat brain microdialysate with 1,2,5,6-dibenzocarbazole-9-ethyl chloroformate as labeling reagent by high performance liquid chromatographic fluorescence detection and mass spectrometric identification. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 879 (2011) 1367-1374. 10.G.L. Li, X.L. Zhang, J.M. You*, C.H. Song, Z.W. Sun, L.A. Xia, and Y.R. Suo, Highly sensitive and selective pre-column derivatization high-performance liquid chromatography approach for rapid determination of triterpenes oleanolic and ursolic acids and application to Swertia species: Optimization of triterpenic acids extraction and pre-column derivatization using response surface methodology. Analytica Chimica Acta 688 (2011) 208-218. 11.G.L. Li, J.M. You*, Y.R. Suo, C.H. Song, Z.W. Sun, L.A. Xia, X.N. Zhao, and J.Y. Shi, A developed pre-column derivatization method for the determination of free fatty acids in edible oils by reversed-phase HPLC with fluorescence detection and its application to Lycium barbarum seed oil. Food Chemistry 125 (2011) 1365-1372. 12.G.L. Li, C.H. Song, J.M. You*, Z.W. Sun, L.A. Xia, and Y.R. Suo, Optimisation of red pepper seed oil extraction using supercritical CO2 and analysis of the composition by reversed-phase HPLC-FLD-MS/MS. International Journal of Food Science and Technology 46 (2011) 44-51. 13.G.L. Li, Y.Y. Cui, J.M. You*, X.N. Zhao, Z.W. Sun, L.A. Xia, Y.R. Suo, and X. Wang, Determination of trace amino acids in human serum by a selective and sensitive pre-column derivatization method using HPLC-FLD-MS/MS and derivatization optimization by response surface methodology. Amino Acids 40 (2011) 1185-1193. 14.J.M. You, C.H. Song, T. Yan, Z.W. Sun, Y.L. Li, and Y.R. Suo, An improved reagent for determination of aliphatic amines with fluorescence and online atmospheric chemical ionization-mass spectrometry identification. Analytica Chimica Acta 658 (2010) 98-105. 15.J.M. You, C.H. Song, Y.Y. Fu, Z.W. Sun, L. Xia, Y.L. Xia, and Y.R. Suo, Dual-sensitive probe 1-imidazole-2-(5-benzoacridine)-ethanone for the determination of amines in environmental water using HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometry identification. Talanta 80 (2010) 1392-1399. 16.J.M. You, Y.Y. Fu, Z.W. Sun, and Y.R. Suo, 2-(5-Benzoacridine)ethyl-p-toluenesulfonate as sensitive reagent for the determination of bile acids by HPLC with fluorescence detection and online atmospheric chemical ionization-mass spectrometric identification. Analytical and Bioanalytical Chemistry 396 (2010) 2657-2666. 17.J.M. You, H.X. Zhao, Z.W. Sun, L. Xia, T. Yan, Y.R. Suo, and Y.L. Li, Application of 10-ethyl-acridine-3-sulfonyl chloride for HPLC determination of aliphatic amines in environmental water using fluorescence and APCI-MS. Journal of Separation Science 32 (2009) 1351-1362. 18.J.M. You, T. Yan, H.X. Zhao, Z.W. Sun, L. Xia, Y.R. Suo, and Y.L. Li, A sensitive fluorescence reagent for the determination of aldehydes from alcoholic beverage using high-performance liquid chromatography with fluorescence detection and mass spectrometric identification. Analytica Chimica Acta 636 (2009) 95-104. 19.J.M. You, X. Sheng, C.X. Ding, Z.W. Sun, Y.R. Suo, H.L. Wang, and W. Li, Detection of carbohydrates using new labeling reagent 1-(2-naphthyl)-3-methyl-5-pyrazolone by capillary zone electrophoresis with absorbance (UV). Analytica Chimica Acta 609 (2008) 66-75. 20.J.M. You, F. Zhu, W.C. Zhao, X.E. Zhao, Y.R. Suo, and S.J. Liu, Analysis of saturated free fatty acids from pollen by HPLC with fluorescence detection. European Journal of Lipid Science and Technology 109 (2007) 225-236.