Miller, Lisa - Stony Brook University - Department of Chemistry

个人简介

Ph.D. 1995: Biophysics, Albert Einstein College of Medicine M.S. 1992: Chemistry, Georgetown University B.S. 1989: Chemistry, John Carroll University

研究领域

Lisa Miller's research focuses on the study of the chemical makeup of cells and tissues using synchrotron-based infrared and x-ray imaging. Her work has three primary research areas: (1) understanding how the nanostructure and chemical composition of bone affect its mechanical properties in osteoarthritis and osteoporosis, (2) elucidating the role of metal ions in protein misfolding and neurodegeneration in Alzheimer's disease and amyotrophic lateral sclerosis, and (3) optimizing nutrient availability in the rhizosphere of plants for improved biomass production.

近期论文

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R.D. Ross, L.H. Edwards, A.S. Acerbo, M. Ominsky, A. Virdi, K. Sena, L.M. Miller, D.R. Sumner. Bone Matrix Quality Following Sclerostin Antibody Treatment. J. Bone Min Res., in press. E. Stavitski, R.J. Smith, M.W. Bourassa, A.S. Acerbo, G.L. Carr, L.M. Miller (2013). Dynamic full-field infrared imaging with multiple synchrotron beams. Anal. Chem. 85(7): 3599-605 [PMID: 23458231]. D.E. Green, B.J. Adler, M.E. Chan, J.J. Lennon, A.S. Acerbo, L.M. Miller, C.T. Rubin (2013). Altered composition of bone as triggered by irradiation facilitates the rapid erosion of the matrix by both cellular and physicochemical processes. PLoS One, 8(5):e64952 [PMID: 23741433]. A. Lanzirotti, S. Bronson, L.M. Miller, K. Nasta (2013). Using the NSLS for Introducing Synchrotrons into the Classroom (InSynC). Synch. Rad. News 26(1): 30-34. R. Tappero, A. Lanzirotti, L.M. Miller, M. Bourassa, R.L. Chaney (2013). High Metal Tolerance in the Seed Embryo of a Hyperaccumulator Revealed by X-ray Fluorescence Microprobe. 12th International Conference on the Biogeochemistry of Trace Elements, Vol 1, p. 379. M.W. Bourassa, A.C. Leskovjan, R. V. Tappero, E.R. Farquhar, C.A. Colton, W.E. Van Nostrand, L.M. Miller (2013). Elevated copper in the amyloid plaques and iron in the cortex are observed in mouse models of Alzheimer’s disease that exhibit neurodegeneration. Biomedical Spectroscopy & Imaging, 2: 129-139. L.M. Miller, M.W. Bourassa, R.J. Smith (2013). FTIR spectroscopic imaging of protein aggregation in living cells. BBA-Biomembranes, 1828 (10): 2339-46 [PMID: 23357359]. M.E. Faillace, R. Phipps, L.M. Miller (2012). Fourier transform infrared imaging as a tool to chemically and spatially characterize matrix-mineral deposition in osteoblasts. Calcif Tissue Int., 92(1): 50-8 [PMID: 23143076]. N. Bivi, M.T. Nelson, M.E. Faillace, J. Li, L.M. Miller, L.I. Plotkin (2012). Deletion of cx43 from osteocytes results in defective bone material properties but does not decrease extrinsic strength in cortical bone. Calcif. Tissue Int. 91(3):215-24 [PMID: 22865265]. L.M. Miller (2012). "Characterization of Neurodegenerative Protein-Misfolding Diseases using FTIR Spectroscopy and Microspectroscopy." In Vibrational Spectroscopy in Diagnosis and Screening. F. Severcan & P.I. Haris, editors. IOS Press, pages 118-137. ISBN: 978-1-61499-058-1. M.W. Bourassa, L.M. Miller (2012). Metal imaging in neurodegenerative diseases. Metallomics, 4(8):721-38 [PMID: 22797194]. R. Pietri, S. Zerbs, D.M. Corgliano, M. Allaire, F.R. Collart, L.M. Miller (2012). Biophysical and structural characterization of a sequence-diverse set of solute binding proteins for aromatic compounds. J. Biol. Chem. 287(28):23748-56 [PMID: 22577139]. A.S. Acerbo, G.L. Carr, S. Judex, L.M. Miller (2012). Imaging the material properties of polished bone specimens using reflection-based infrared microspectroscopy. Anal. Chem. 84(8): 3607-13 [PMID:22455306] G. Cakmak, L.M. Miller, F. Zorlu, F. Severcan (2012). Amifostine, a radioprotectant agent, protects rat brain tissue lipids against ionizing radiation induced damage: An FTIR microspectroscopic imaging study. Arch Biochem Biophys. 520(2):67-73. [PMID: 22402174]. J.Y. Gou, L.M. Miller, G. Hou, X.H. Yu, X.Y. Chen, and C.J. Liu (2012). Acetylesterase-Mediated Deacetylation of Pectin Impairs Cell Elongation, Pollen Germination, and Plant Reproduction. Plant Cell. 24(1):50-65 [PMID: 22247250]. A. Bhatia, M. Albazzaz, A.A. Espinoza Orias, N. Inoue, L.M. Miller, A. Acerbo, A. George, D.R. Sumner (2012). Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo. J. Mech. Behavior Biomed. Mater. 5(1):1-8. [PMID:22100074] S.M. Tommasini, A. Trinward, A. Acerbo, F. DeCarlo, L.M. Miller, S. Judex (2012). Changes in intracortical microporosities induced by pharmaceutical treatment of osteoporosis as detected by high resolution micro-CT. Bone, 50(3): 596-604. [PMID:22226688] M. Bonda, V. Perrin, B. Vileno, H. Runne, A. Kretlow, L. Forró, R. Luthi-Carter, L.M. Miller, S. Jeney (2011). Synchrotron Infrared Microspectroscopy Detecting the Evolution of Huntington's Disease Neuropathology and Suggesting Unique Correlates of Dysfunction in White versus Gray Brain Matter. Anal. Chem. 83(20): 7712-20. [PMID: 21888376] H.L. Lelie, A. Liba, M.W. Bourassa, M. Chattopadhyay, P.K. Chan, E.B Gralla, L.M. Miller, D.R. Borchelt, J.S. Valentine, J.P. Whitelegge (2011). Copper and Zinc Metallation Status of SOD1 from ALS-Transgenic Mice. J. Biol. Chem. 286(4): 2795-806. [PMID: 21068388] R.K. Fuchs, M.E. Faillace, M.R. Allen, R.J. Phipps, L.M. Miller, D.B. Burr (2011). Bisphosphonates do not alter the rate of secondary mineralization. Bone 49(4): 701-5. A.L. Leskovjan, A. Kretlow, A. Lanzirotti, R. Barrea, S. Vogt, L.M. Miller (2011). Increased brain iron coincides with early plaque formation in a Mouse Model of Alzheimer’s Disease. NeuroImage, 55(1): 32-8. [PMID: 21126592]