Liu, Zhijie (Jason) - University of Texas Health San Antonio - Graduate School of Biomedical Sciences

个人简介

2016 Postdoctoral Training The Howard Hughes Medical Institute, University of California at San Francisco, CA 2008 Postdoctoral Training University of Georgia, Athens, GA 2007 PhD Genetics University of Georgia, Athens, GA 2002 MS Molecular Genetics Chinese Academy of Sciences Beijing, China 1999 BS Biochemistry Lanzhou University Lanzhou, Gansu, China

研究领域

(1) Explore the roles and regulation mechanisms of signaling-dependent gene regulation programs in normal development and disease conditions, and study how context-specific gene programs are regulated by the crosstalk of different signaling pathways. (2) Decipher the epigenetic and 3D architectural changes of the cis-regulatory elements upon developmental/pathological stimuli and during hormone/drug resistance acquisition in cancers. (3) Based on our understanding of gene regulation mechanisms, identify diagnostic/prognostic biomarkers and therapeutic targets for multiple human cancer types. (4) Develop drugs and therapeutics for pre-clinical studies and potential clinical applications.

近期论文

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Su Hyuk Ko, Ellen Apple, Zhijie Liu*, Lizhen Chen*. Age-dependent autophagy induction after injury promotes axon regeneration via limiting Notch. Autophagy. Published online: 13 Jan 2020. PMID: 31920157 (*co-corresponding author) Chi Zhu, Li Li, Zhao Zhang, Mingjun Bi, Karen Hernandez, Wenyue Su, Junqiang Chen, Tim Hui-Ming Huang, Lizhen Chen, and Zhijie Liu*. A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer. Molecular Cell. 2019 Aug 22;75(4):791-806. PMID: 31303470 (*lead author) Joshua E Mayfield, Seema Irani, Edwin E Escobar, Zhao Zhang, Nathaniel T Burkholder, Michelle R Robinson, M Rachel Mehaffey, Sarah N Sipe, Wanjie Yang, Nicholas A Prescott, Karan Kathuria, Zhijie Liu, Jennifer Brodbelt, Yan Zhang. Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb. eLife. 2019 Aug 6; doi: 10.7554/eLife.48725. PMID: 31385803 Shiyan Wang, Jiahuan Chen, Sara P. Garcia, Xiaodong Liang, Fang Zhang, Pengyi Yan, Huijing Yu, Weiting Wei, Zixuan Li, Jingfang Wang, Huangying Le, Zeguang Han, Xusheng Luo, Daniel S. Day, Sean M. Stevens, Yan Zhang, Peter J. Park, Zhijie Liu, et al., and Bing Zhang. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Research. 2019 Feb; 29(2):193-207. PMID: 30670628 Aiping Xu, Zhao Zhang, Su‐Hyuk Ko, Alfred L. Fisher, Zhijie Liu, Lizhen Chen. Microtubule regulators regulate neuronal aging and organismal longevity through DAF-16 in C. elegans. Aging Cell. 2019 Jan 14:e12884. PMID: 30638295 Aaron M. Horning, Yao Wang, Che-Kuang Lin, Anna D. Louie, Rohit R. Jadhav, Chia-Nung Hung, Chiou-Miin Wang, Chun-Lin Lin, Nameer B. Kirma, Michael A. Liss, Addanki P. Kumar, LuZhe Sun, Zhijie Liu, Wei-Ting Chao, Qianben Wang, Victor X. Jin, Chun-Liang Chen and Tim H.-M. Huang. Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle–Related Transcription and Attenuated Androgen Response. Cancer Research. 2018 Feb 15; 78 (4): 853-864. PMID: 29233929 Feng Yang, Qi Ma, Zhijie Liu, Wenbo Li, Yuliang Tan, Chunyu Jin, Wubin Ma, Yiren Hu, Jia Shen, Kenneth A. Ohgi, Francesca Telese, Wen Liu and Michael G. Rosenfeld. Glucocorticoid Receptor: MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program. Molecular Cell. 2017 May 4;66(3):321-331. PMID: 28475868 Lizhen Chen, Zhijie Liu, Bing Zhou, Chaoliang Wei, Yu Zhou, Michael G. Rosenfeld, Xiangdong Fu, Andrew D. Chisholm, and Yishi Jin. CELF RNA binding proteins promote axon regeneration in C. elegans and mammals through alternative splicing of syntaxins. eLife. 2016 Jun 2; doi: 10.7554/eLife.16072. PMID: 27253061 Jianxun Wang, Francesca Telese, Yuliang Tan, Wenbo Li, Chunyu Jin, Xin He, Harihar Basnet, Qi Ma, Daria Merkurjev, Xiaoyan Zhu, Zhijie Liu, et al., and Michael G. Rosenfeld. LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nature Neuroscience. 2015 Sep; 18(9): 1256-1264. PMID: 26214369 Wenbo Li, Yiren Hu, Soohwan Oh, Qi Ma, Daria Merkurjev, Xiaoyuan Song, Xiang Zhou, Zhijie Liu, et al., and Michael G. Rosenfeld. Condensin I and II complexes license full estrogen receptor α-dependent enhancer activation. Molecular Cell. 2015 Jul 16; 59(2): 188–202. PMID: 26166704 Feng Zhang, Bogdan Tanasa, Daria Merkurjev, Chijen Lin, Xiaoyuan Song, Wenbo Li, Yuliang Tan, Zhijie Liu, et al., and Michael G. Rosenfeld. Enhancer-bound LDB1 regulates a corticotrope promoter pausing repression program. PNAS. 2015 Feb 3; 112(5): 1380-5. PMID: 25605944 Janusz Puc, Piotr Kozbial, Wenbo Li, Yuliang Tan, Zhijie Liu, Tom Suter, Kenneth A. Ohgi, Jie Zhang, Aneel K. Aggarwal, and Michael G. Rosenfeld. Ligand-dependent enhancer activation requires topoisomerase-I catalytic activity. Cell. 2015 Jan 29; 160(3): 367-80. PMID: 25619691 Zhijie Liu*, Daria Merkurjev, Feng Yang, Wenbo Li, et al., and Michael G. Rosenfeld. Enhancer activation requires trans-recruitment of a mega transcription factor complex. Cell. 2014 Oct 9; 159(2): 358-73. PMID: 25303530 (*first and co-corresponding author) Zhijie Liu*, Qidong Hu, and Michael G. Rosenfeld. Complexity of the RAR-mediated transcriptional regulatory programs. Chapter 10 of Book “The biochemistry of retinoic acid receptors I: structure, activation, and function at the molecular Level”. Subcellular Biochemistry. 2014; 70: 203-225. PMID: 24962887 (*first and co-corresponding author) Dorota Skowronska-Krawczyk, Qi Ma, Michal Schwartz, Kathleen Scully, Wenbo Li, Zhijie Liu, et al., and Michael G. Rosenfeld. Required interactions of enhancers with Matrin-3 nuclear architecture for transcriptional activation by homeodomain factors. Nature. 2014 Aug 3; 514(7521): 257-61. PMID: 25119036 Kaitlin A. G. Reeh, Kim T. Cardenas, Virginia E. Bain, Zhijie Liu, Micheline Laurent, Nancy R. Manley and Ellen R. Richie. Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug; 141(15): 2950-8. PMID: 25053428 Jie Li, Zhijie Liu, Shiyun Xiao and Nancy Manley. Transdifferentiation of parathyroid cells into cervical thymi promotes atypical T cell development. Nature Communications. 2013 Dec 17; 4:2959. PMID: 24343363 Zhijie Liu, Alison Farley, Lizhen Chen, Beth J. Kirby, Christopher S. Kovacs, C. Clare Blackburn, Nancy Manley. Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genetics. 2010 Dec 23; 6(12):e1001251. PMID: 21203493 Zhijie Liu, Shannon Yu, Nancy Manley. Gcm2 is required for the differentiation and survival of parathyroid precursor cells in parathyroid/thymus primordia. Developmental Biology. 2007 May 1; 305(1): 333-46. PMID: 17382312 Cunlan Liu, Fumi Saito, Zhijie Liu, Yu Lei, Shoji Uehara, Paul Love, Martin Lipp, Shunzo Kondo, Nancy Manley, and Yousuke Takahama. Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood. 2006 Oct 15; 108(8): 2531-9. PMID: 16809609