Chen, Youhai - The University of Pennsylvania - Department of Pathology and Laboratory Medicine

个人简介

M.D. (Medicine)Shandong University, Shandong, China, 1986. Ph.D. (Immunology)University of Manitoba, Winnipeg, Manitoba, Canada, 1993. Post-Doc. (Immunology)Harvard University, Boston, Massachusetts, USA, 1995.

研究领域

Immunity, Inflammation, Cancer, and Gene Therapy

近期论文

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Carmody, R. J., Q. Ruan, S. Palmer, B. Hilliard, Y. H. Chen: Negative regulation of Toll-like receptor signaling by NF-kB p50 ubiquitination blockade. Science 317(5838): 675-678, 2007. Sun, H., S. Gong, R. J. Carmody, A. Hilliard, L. Li, J. Sun, L. Xu, B. Hilliard, S. Hu, H. Shen, X. Yang, Y. H. Chen: TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell 133: 415-426, 2008. Ruan, Q., V. Kameswaran, Y. Tone, L. Li, H-C. Liou, M.I. Greene, M. Tone, Y.H. Chen: Development Of Foxp3+ Regulatory T Cells Is Driven By The c-Rel Enhanceosome. Immunity 31: 932-940, 2009. Sheedy, F.J., E. Palsson-McDermott, E.J. Hennessy, C. Martin, J. O’Leary, Q. Ruan, D.P Johnson, Y.H. Chen, and L.A.J. O’Neill: Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nature Immunology 11: 141-147, 2010. Li Li, Ruan Qingguo, Hilliard Brendan, Devirgiliis Jennifer, Karin Michael, Chen Youhai H: Transcriptional regulation of the Th17 immune response by IKK(alpha). The Journal of Experimental Medicine 208(4): 787-96, Apr 2011. Ruan Qingguo, Wang Ting, Kameswaran Vasumathi, Wei Qin, Johnson Derek S, Matschinsky Franz, Shi Weiyun, Chen Youhai H: The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proceedings of the National Academy of Sciences USA 108(29): 12030-12035, Jul 2011. Ruan Qingguo, Kameswaran Vasumathi, Zhang Yan, Zheng Shijun, Sun Jing, Wang Junmei, Devirgiliis Jennifer, Liou Hsiou-Chi, Beg Amer A, Chen Youhai H: The Th17 immune response is controlled by the Rel-ROR{gamma}-ROR{gamma}T transcriptional axis. The Journal of Experimental Medicine 208: 2321-33, Oct 2011. Gus-Brautbar Yael, Johnson Derek, Zhang Li, Sun Honghong, Wang Peng, Zhang Shirley, Zhang Lining, Chen Youhai H: The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras. Molecular Cell 9(45): 610-8, Feb 2012. Fayngerts Svetlana A, Wu Jianping, Oxley Camilla L, Liu Xianglan, Vourekas Anastassios, Cathopoulis Terry, Wang Zhaojun, Cui Jian, Liu Suxia, Sun Honghong, Lemmon Mark A, Zhang Lining, Shi Yigong, Chen Youhai H: TIPE3 is the transfer protein of lipid second messengers that promote cancer. Cancer Cell 26(4): 465-78, 2014. Fayngerts Svetlana A, Wang Zhaojun, Zamani Ali, Sun Honghong, Boggs Amanda E, Porturas Thomas P, Xie Weidong, Lin Mei, Cathopoulis Terry, Goldsmith Jason R, Vourekas Anastassios, Chen Youhai H: Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nature Immunology 18(12): 1353-1360, Dec 2017. Chen Gang, Huang Alexander C, Zhang Wei, Zhang Gao, Wu Min, Xu Wei, Yu Zili, Yang Jiegang, Wang Beike, Sun Honghong, Xia Houfu, Man Qiwen, Zhong Wenqun, Antelo Leonardo F, Wu Bin, Xiong Xuepeng, Liu Xiaoming, Guan Lei, Li Ting, Liu Shujing, Yang Ruifeng, Lu Youtao, Dong Liyun, McGettigan Suzanne, Somasundaram Rajasekharan, Radhakrishnan Ravi, Mills Gordon, Lu Yiling, Kim Junhyong, Chen Youhai H, Dong Haidong, Zhao Yifang, Karakousis Giorgos C, Mitchell Tara C, Schuchter Lynn M, Herlyn Meenhard, Wherry E John, Xu Xiaowei, Guo Wei: Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560: 382–386 Aug 2018. Ting Li, Xinyuan Li, Ali Zamani, Wei Wang, Chin-Nien Lee, Mingyue Li, George Luo, Emily Eiler, Honghong Sun, Sankar Ghosh, Jian Jin, Ramachandran Murali, Qingguo Ruan, Weiyun Shi & Youhai H. Chen: c-Rel is a myeloid checkpoint for cancer immunotherapy. Nature Cancer 1: 507-517; https://rdcu.be/b4ffJ, 2020. Wang Y, Zhang H, Wang Z, Wei Y, Wang M, Liu M, Wang X, Jiang Y, Shi G, Zhao D, Yang Z, Ren Z, Li J, Zhang Z, Wang Z, Zhang B, Zong B, Lou X, Liu C, Wang Z, Zhang H, Tao N, Li X, Zhang X, Guo Y, Ye Y, Qi Y, Li H, Wang M, Guo R, Cheng G, Li S, Zhang J, Liu G, Chai L, Lou Q, Li X, Cui X, Gao E, Dong Z, Hu Y, Chen YH, Ma Y. : Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Science Translational Medicine 12: doi: 10.1126/scitranslmed.aaw3172, 2020. Jason R Goldsmith, Nina Spitofsky, Ali Zamani, Ryan Hood, Amanda Boggs, Xinyuan Li, Mingyue Li, Elizabeth Reiner, Arshad Ayyaz, Zienab Etwebi, Ling Lu, Javier Rivera Guzman, Mayassa J. Bou-Dargham, Terry Cathoupolis, Hakon Hakonarson, Honghong Sun, Jeffrey L. Wrana, Michael V. Gonzalez, Youhai H Chen: TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling. Nature Communications 11: doi.org/10.1038/s41467-020-16379; https://rdcu.be/b4lmc, 2020.