陈振 - 清华大学 - 化学工程系

个人简介

教育与工作经历 2001-2005 清华大学化工系，学士 2005-2008 清华大学化工系/东京工业大学生命理工学院，硕士 2008-2012 德国汉堡工业大学，博士 2012-2013 德国汉堡工业大学，博士后 2013-2017 清华大学化工系，助理教授 2017-至今清华大学化工系，副教授主要学术任职 Frontiers in Bioengineering and Biotechnology 编委第三届全国发酵工程技术工作委员会委员中国化工学会精细化工专业委员会青年委员

研究领域

1.）蛋白质的理性设计。基于蛋白质结构，蛋白质的动力学和蛋白质序列进化信息研究蛋白质的构效关系，以此为基础设计蛋白质的新功能，如催化新的化学反应及构建非天然的别构效应。相关的结果成功运用到氨基酸的生产中，，开发了具有完全自主知识产权的高产赖氨酸，色氨酸等的生产菌种。 2.）非天然代谢途径的设计。自然界中已知的代谢途径是有限的，不足以生产我们需要的各种产品，如何构建这些非天然代谢途径来生产这些具有重要价值的化合物是工业生物技术面临的一个重要挑战。我们致力于研究设计非天然代谢途径的理论基础，借鉴有机合成的思路，开发基于反向合成的代谢途径设计方法。同时整合酶的设计与筛选，代谢途径的热力学分析与评价，基因组水平的代谢途径设计与优化，建立设计细胞工厂的理论基础。 3.）氨基酸生产菌株的构建。包括谷氨酸，赖氨酸，色氨酸等氨基酸高产工业菌株的构建与优化。 4.）C3-C6 二元醇（1,3-丙二醇，2,3-丁二醇，1,5-戊二醇，1,6-已二醇）生产菌株的构建与优化。

近期论文

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Zhu F, Liu DH*, Chen Z*. Recent advances in biological production of 1,3-propanediol: new routes and engineering strategies，Green Chemistry, DOI: 10.1039/D1GC04288B (2022). Li Z, Dong Y, Liu Y, Cen X, Liu DH, Chen Z*. Systems metabolic engineering of Corynebacterium glutamicum for high-level production of 1,3-propanediol from glucose and xylose，Metabolic engineering, 70,79-88 (2022). Cen X, Liu Y, Chen B, Liu DH, Chen Z*. Metabolic engineering of Escherichia coli for de novo production of 1,5-pentanediol from glucose，ACS Synthetic Biology, 10(1), 192?203 (2021) . Liu Y, Cen X, Liu DH, Chen Z*. Metabolic engineering of Escherichia coli for high-yield production of (R)-1,3-butanediol，ACS Synthetic Biology, 10(8), 1946?1955 (2021) . Zhang Y, Li Z, Liu Y, Cen X, Liu DH, Chen Z*. Systems metabolic engineering of Vibrio natriegens for the production of 1, 3-propanediol，Metabolic Engineering, 65, 52-65 (2021) . Li Z, Wu Z, Cen X, Liu Y, Zhang Y, Liu DH, Chen Z*. Efficient production of 1, 3-propanediol from diverse carbohydrates via a non-natural pathway using 3-hydroxypropionic acid as an intermediate，ACS Synthetic Biology, 10 (3), 478-486 (2021) . Zhong W, Zhang Y, Wu W, Liu DH, Chen Z*. Metabolic engineering of a homoserine-derived non-natural pathway for the de novo production of 1,3-propanediol from glucose，ACS Synthetic Biology, 8 (3), 587-595 (2019). Wu W, Zhang Y, Liu DH, Chen Z*. Efficient mining of natural NADH-utilizing dehydrogenases enables systematic cofactor engineering of lysine synthesis pathway of Corynebacterium glutamicum，Metabolic Engineering, 52, 77-86 (2019) . Chen Z*, Huang J, Wu Y, Wu W, Zhang Y, Liu DH. Metabolic engineering of Corynebacterium glutamicum for the production of 3-hydroxypropionic acid from glucose and xylose，Metabolic Engineering, 39, 151-158 (2017) . Chen Z*, Liu DH, Toward glycerol biorefinery: metabolic engineering for the production of biofuels and chemicals from glycerol，Biotechnology for Biofuels, 9 (1), 1-15 (2016) . Chen Z, Zeng AP *. Protein engineering approaches to chemical biotechnology，Current Opinion in Biotechnology, 42, 198-205 (2016) . Chen Z*, Huang J, Wu Y, Liu DH. Metabolic engineering of Corynebacterium glutamicum for the de novo production of ethylene glycol from glucose，Metabolic Engineering, 33, 12-18 (2016). Chen Z, Geng F, Zeng AP *. Protein design and engineering of a de novo pathway for microbial production of 1, 3-propanediol from glucose，Biotechnology Journal, 10 (2), 284-289 (2015) . Chen Z, Rappert S, Zeng AP*. Rational design of allosteric regulation of homoserine dehydrogenase by a nonnatural inhibitor L-lysine，ACS Synthetic Biology, 4 (2), 126-131 (2015) . Bommareddy RR #, Chen Z#, Rappert S, Zeng AP*. A de novo NADPH generation pathway for improving lysine production of Corynebacterium glutamicum by rational design of the coenzyme specificity of glyceraldehyde 3-phosphate dehydrogenase，Metabolic Engineering, 25, 30-37 (2014) .