个人简介
1998年开始从事生物分离材料和生物分离工程的研究。针对新型整体柱的合成和应用进行了系列的尝试,成功开发了可以应用生物大分子分离的聚合物型整体柱材料。随后,开发了固液联合致孔的双孔型材料制备方法。之后,成功合成了可以用于神经酰胺等生物活性成分分离纯化的分子印迹整体柱。2010年开始将研究领域进一步拓展至生物分子分析的相关领域。作为负责人,先后开展了磷脂样品关键组分分析,磷脂原料药、冻干粉和混悬液的质谱分析,芬多萜鼻炎制剂分析等药品和制剂的成分分析。2016年开始,作为国家重点研发计划项目的子课题“典型生物处理条件下特征组分分子间相互作用与品质功能调控机制”负责人,在豆腐凝乳机制方面进行了系列的研究。发表SCI收录刊物论文15篇,参与撰写中文专著1部,公开和授权发明专利16项。
教育与工作经历
1991.9-1995.7 天津大学应用化学系 高分子化工 学士学位
1995.9-1998.2 天津大学应用化学系 高分子材料 硕士学位
1998.3-2001.6 天津大学化工学院 生物化工 博士学位
2001.9-2003.9 清华大学化学工程系 博士后
2003.10-2005.10 清华大学化学工程系 讲师
2006~至今 清华大学化学工程系 副研究员
近期论文
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Zhang ML, Hu D, Liu MR. 2010. Application of Ion Exchange Chromatography for Pharmaceutical Plasmid Analysis. PROGRESS IN CHEMISTRY 22(2-3): 482-488
Ge J, Yan M, Lu DN, Zhang ML, Liu Z. 2007. Hyperbranched polymer conjugated lipase with enhanced activity and stability. BIOCHEMICAL ENGINEERING JOURNAL, 36 (2): 93-99.
Lu DN, Liu ZX, Zhang ML, Wang XG, Liu Z. 2006. Dextran-grafted-PNIPAAm as an artificial chaperone for protein refolding. BIOCHEMICAL ENGINEERING JOURNAL, 27 (3): 336-343. 3. Lu D, Liu ZX, Zhang ML, Liu Z, Zhou HM. 2005. The mechanism of PNIPAAm-assisted refolding of lysozyme denatured by urea. BIOCHEMICAL ENGINEERING JOURNAL, 24 (1): 55-64.
Dong WG, Yan M, Zhang ML, Liu Z, Li YM. 2005. A computational and experimental investigation of the interaction between the template molecule and the functional monomer used in the molecularly imprinted polymer. ANALYTICA CHIMICA ACTA, 542 (2): 186-192. 936XR
Lu DN, Liu Z, Liu ZX, Zhang ML, Ouyang P. 2005. Molecular simulation of surfactant-assisted protein refolding. JOURNAL OF CHEMICAL PHYSICS, 122 (13): Art No.134902. (SCI:916MP EI: 05379353876)
Zhang ML, Xie JP, Zhou Q, Chen GQ, Liu Z. 2003. On-line solid-phase extraction of ceramides from yeast with ceramide III imprinted monolith. JOURNAL OF CHROMATOGRAPHY A, 984 (2): 173-183. (SCI: 633XJ他引 23次 EI:02527293219)
Zhang ML, Sun Y. 2001. Cooperation of solid granule and solvent as porogenic agents - Novel porogenic mode of biporous media for protein chromatography. JOURNAL OF CHROMATOGRAPHY A, 922 (1-2): 77-86.
Zhang ML, Sun Y. 2001. Poly(glycidyl methacrylate-divinylbenzene-triallylisocyanurate) continuous-bed protein chromatography. JOURNAL OF CHROMATOGRAPHY A, 912 (1): 31-38.
Yu JG, Li HS, Zhang MQ, Zhang ML. 2000. Study on degradation mechanism of polyethylene films containing additives with metal ions at a simulated composting temperature. JOURNAL OF APPLIED POLYMER SCIENCE, 75(4): 523-527. (SCI:261MK)
Chen TH, Li HS, Gao Y, Zhang ML. 1998. Study on epoxy resins modified by polycarbonate polyurethanes JOURNAL OF APPLIED POLYMER SCIENCE, 69(5): 887-893.