个人简介
致力于面向微生物智能制造，开展高通量基因型－表型关联原创技术与装备的研究，包括微生物工业表型高通量表征与连续进化，全基因组规模基因及位点功能挖掘，基因型与工业表型关联研究装备等。在Nature Chemical Biology，Nature Communications, Nucleic Acid Research, Metabolic Engineering，ACS Synthetic Biology，Biotechnology and Bioengineering等刊物发表SCI收录论文近100篇。所持有的20余项专利中有5项通过授权实施许可实现产业化，创造了良好的经济效益。主持制定5项微生物育种共性技术国家标准。主持国家自然科学基金重点、面上、青年项目4项，国家重点研发计划课题2项等国家和企业合作课题10余项。
教育与工作经历
1998~2002 清华大学化学工程系 本科
2002~2008 清华大学化学工程系 博士
2008~2010 清华大学化学工程系 博士后
2010~2011 清华大学化学工程系 助理研究员
2011~2023 清华大学化学工程系 副教授
2023~至今 清华大学化学工程系 教授
学术荣誉与奖励
亚洲生物技术青年科学家奖（日本生物工学会，2020）
中国轻工业联合会技术发明一等奖（2019）
教育部高层次青年人才计划（2018）
伦世仪教育基金会发酵工程杰出青年学者奖（2018）
日内瓦国际发明博览会金奖（2017）
清华大学教育教学成果一等奖（2016）
近期论文
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Feng, H., Guo, J., Wang, T., Zhang, C.*, & Xing, X.-H. Guide-target mismatch effects on dCas9–sgRNA binding activity in living bacterial cells, Nucleic Acids Research 49, 3, 1263–1277, (2021)
Wang, T.*, Zheng, X., Ji, H., Wang, T. L., Xing, X. H., & Zhang, C.*. Dynamics of transcription–translation coordination tune bacterial indole signaling. Nature Chemical Biology 16, 440–449, (2020)
Jian, X., Guo, X., Wang, J., Tan, Z.L., Xing, X. H., Wang, L. Y.*, Zhang, C.*. Microbial microdroplet culture system (MMC): an integrated platform for automated, high–throughput microbial cultivation and adaptive evolution. Biotechnology and Bioengineering 117, 6, 1724-1737 (2020)
Wang, T., Guan, C., Guo, J., Liu, B., Wu, Y., Xie, Z., Zhang, C.* & Xing, X.-H. Pooled CRISPR interference screening enables genome-scale functional genomics study in bacteria with superior performance. Nature Communications 9, 2475 (2018).
Guo, J., Wang, T., Guan, C., Liu, B., Luo, C., Xie, Z., Zhang, C.* & Xing, X.-H. Improved sgRNA design in bacteria via genome-wide activity profiling. Nucleic Acids Research 46, 7052-7069, (2018).
Zhou, Y., Li, G., Dong, J., Xing, X.-H., Dai, J.* & Zhang, C.*. MiYA, an efficient machine-learning workflow in conjunction with the YeastFab assembly strategy for combinatorial optimization of heterologous metabolic pathways in Saccharomyces cerevisiae. Metabolic Engineering 47, 294-302, (2018).
Liang, W.-F., Cui, L.-Y., Cui, J.-Y., Yu, K.-W., Yang, S., Wang, T.-M., Guan, C.-G., Zhang, C.* & Xing, X.-H. Biosensor-assisted transcriptional regulator engineering for Methylobacterium extorquens AM1 to improve mevalonate synthesis by increasing the acetyl-CoA supply. Metabolic Engineering 39, 159-168 (2017).
Liu, S.-D., Wu, Y.-N., Wang, T.-M., Zhang, C.*. & Xing, X.-H. Maltose Utilization as a Novel Selection Strategy for Continuous Evolution of Microbes with Enhanced Metabolite Production. ACS Synthetic Biology 6, 2326-2338, (2017).
Fang, M., Wang, T., Zhang, C.*, Bai, J., Zheng, X., Zhao, X., Lou, C. & Xing, X.-H. Intermediate-sensor assisted push-pull strategy and its application in heterologous deoxyviolacein production in Escherichia coli. Metabolic Engineering 33, 41-51, (2016).
学术兼职
担任Journal of Bioscience Bioengineering，BMC Biotechnology、Engineering Biology、合成生物学等期刊编委，中国生物发酵产业协会生物育种分会秘书长，中国医药生物技术协会合成生物技术分会委员
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