车永胜 - 中国医学科学院医药生物技术研究所 -

个人简介

1989、1995、2000年分别在南开大学、Clarkson University、University of Iowa获得学士、硕士、博士学位，其后在OSI制药公司（Astellas）与Givaudan从事天然药物与功能产品研发。2005年任微生物研究所研究员；2010年任军事医学科学院毒物药物研究所研究员；2018年任中国医学科学院医药生物技术研究所研究员。任中国菌物学会常务理事（2008–）、副理事长（2011–2017），获戴芳澜科学技术奖杰出成就奖（2016；中国菌物学会）；曾任真菌学国家重点实验室第一届学术委员会副主任委员（2012–2017）；目前任天然产物化学研究领域重要期刊Journal of Natural Products顾问编委。

研究领域

主要从事微生物（真菌）来源药物先导分子的发现优化、化学生物学、生物合成与合成生物学制备技术研究。

近期论文

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1. Zou, X.; Niu, S.; Ren, J.; Li, E.;* Liu, X.; Che, Y.* 2011. Verrucamides A–D, antibacterial cyclopeptides from the ascomycete fungus Myrothecium verrucaria. J. Nat. Prod. 74(5): 1111–1116. 2. Li, J.; Li, L.; Si, Y.; Jiang, X.; Guo, L.; Che, Y.* 2011. Virgatolides A–C, benzannulated spiroketals from the plant endophytic fungus Pestalotiopsis virgatula. Org. Lett. 13 (10): 2670–2673. 3. Zhang, N.; Chen, Y.; Jiang, R.; Li, E.; Chen, X.; Xi, Z.; Guo, Y.; Liu, X.; Zhou, Y.; Che, Y.*; Jiang, X.* 2011. PARP and RIP1 are required for autophagy induced by 11’-deoxyverticillin A, which precedes caspase-dependent apoptosis. Autophagy 7(6): 598–612. 4. Ding, G.; Zhang, F.; Chen, H.; Guo, L.; Zou, Z.*; Che, Y.* 2011. Pestaloquinols A and B, isoprenylated epoxyquinol derivatives from Pestalotiopsis sp. J. Nat. Prod. 74(2): 286–291. 5. Liu, L.; Bruhn, T.; Guo, L.; Götz, D. C. G.; Brun, B.; Stich, A.; Che, Y.*; Bringmann, G.* 2011. Chloropupukeanolides C–E, cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chem. Eur. J. 17(9): 2604–2613. (Cover Picture) 6. Ma, C.; Li, Y.; Niu, S.; Zhang, H.; Liu, X.; Che, Y.* 2011. N-Hydroxypyridones, phenylhydrazones, and a quinazolinone from Isaria farinosa. J. Nat. Prod. 74(1): 32–37. 7. Wang, Y.; Niu, S.; Liu, S.; Guo, L.; Che, Y.* 2010. The first naturally occurring thiepinols and thienol from an endolichenic fungus Coniochaeta sp. Org. Lett. 12(21): 5081–5083. (Nat. Prod. Rep. ""Hot off the press”) 8. Li, Y.; Niu, S.; Sun, B.; Liu, S.; Liu, X.; Che, Y.* 2010. Cytosporolides A–C, antimocrobial meroterpenoids with a unique peroxylactone skeleton from Cytospora sp. Org. Lett. 12(14): 3144–3147. (Nat. Prod. Rep. “Hot off the press”) 9. Liu, L.; Gao, H.; Chen, X.; Cai, X.; Yang, L.; Guo, L.; Yao, X.; Che, Y.* 2010. Brasilamides A–D, sesquiterpenoids from the plant endophytic fungus Paraconiothyrium brasiliense. Eur. J. Org. Chem. 3302–3306. 10. Wang, Y.; Zheng, Z.; Liu, S.; Zhang, H.; Li, E.; Guo, L.; Che, Y.* 2010. Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp. J. Nat. Prod. 73(5): 920–924. 11. Lin, J.; Liu, S.; Sun, B.; Niu, S.; Li E,* Liu, X.; Che, Y.* 2010. Polyketides from the ascomycete fungus Leptosphaeria sp. J. Nat. Prod. 73(5): 905–910. 12. Liu, L.; Niu, S.; Lu, X.; Chen, X.; Zhang, H.; Guo, L.; Che, Y.* 2010. Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels-Alder reaction and then mechanistic diversification. Chem. Commun. 46(3): 460–462. (Nat. Prod. Rep.""Hot off the press”) 13. Li, J.; Liu, S.; Niu, S.; Zhuang, W.; Che, Y.* 2009. Pyrrolidinones from the ascomycete fungus Albonectria rigidiuscula. J. Nat. Prod. 72(12): 2184–2187. 14. Guo, H.; Sun.; B, Gao, H.; Chen, X.; Liu, S.; Yao, X.; Liu, X.; Che, Y.* 2009. Diketopiperazines from the Cordyceps-colonizing fungus Epicoccum nigrum. J. Nat. Prod. 72(12): 2115–2119. 15. Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.* 2009. Allenyl and alkynyl phenyl ethers from the endolichenic fungus Neurospora terricola. J. Nat. Prod. 72(10): 1782–1785. 16. Guo, H.; Sun, B.; Gao, H.; Niu, S.; Liu, X.; Yao, X.; Che, Y.* 2009. Trichocladinols A–C, cytotoxic metabolites from a Cordyceps-colonizing ascomycete Trichocladium opacum. Eur. J. Org. Chem. 32: 5525–5530. 17. Zhang, Y.; Liu, S.; Liu, H.;* Liu, X.; Che, Y.* 2009. Cycloaspeptides F and G, cyclic pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa. J. Nat. Prod. 72(7): 1364–1367. 18. Liu, L.; Liu, S.; Niu, S.; Guo, L.; Chen, X.; Che, Y.* 2009. Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. J. Nat. Prod. 72(8): 1482–1486. 19. Liu, L.; Li, Y.; Liu, S.; Zheng, Z.; Chen, X.; Zhang, H.; Guo, L.; Che, Y.* 2009. Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. Org. Lett. 11(13): 2836–2839. (Nat. Prod. Rep. “Hot off the press”) 20. Chen, Y.; Guo, H.; Du, Z.; Liu, X.; Che, Y.;* Ye, X.* 2009. Ecology-based screen identifies new metabolites from a Cordyceps-colonizng fungus as cancer cell proliferation inhibitors and apoptosis inducers. Cell Prolif. 42(6): 838–847."