赵明辉 - 北京大学

个人简介

北京大学教授、主任医师。北京大学肾脏病研究所所长北京大学-清华大学生命科学联合中心(CLS)临床研究员 1987年毕业于北京医科大学，师从王海燕教授开始了ANCA相关小血管炎的研究工作。1991-1996年赴英国剑桥大学留学，师从国际著名血管炎专家CM. Lockwood教授，继续ANCA相关小血管炎的免疫发病机制研究。1996年回国，在北京大学第一医院肾内科暨北京大学肾脏病研究所工作至今。30年来一直致力于引起尿毒症的疑难和危重肾脏病临床与科研工作。

研究领域

肾脏疾病免疫炎症发病机制和慢性肾脏病防治，涉及ANCA相关小血管炎、抗肾小球基底膜病和狼疮肾炎等危重和疑难肾脏疾病。基础与临床相结合的研究，提出了在病因学、新型诊断与鉴别诊断的生物标志物和新疗法等方面的新见解

近期论文

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1. Chen M, Kallenberg CGM, Zhao MH. Antineutrophil cytoplasmic autoantibodies-negative pauci-immune crescentic glomerulonephritis Nat Rev Nephrol. 2009;5(6):313-318. 2. Cui Z, Zhao MH. Advances in human antiglomerular basement membrane disease Nat Rev Nephrol. 2011;7:697-706. 3. Chen M, Gao Y, Guo XH, Zhao MH. Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nat Rev Nephrol. 2012;8(8):476-83.. 4. Wu LH, Yu F, Tan Y, Qu Z, Chen MH, Wang SX, Liu G, Zhao MH. Inclusion of renal vascular lesions in the 2003 ISN/RPS system for classifying lupus nephritis improves renal outcome predictions. Kidney Int. 2013;83(4):715-23. 5. Chen M, Jayne DR, Zhao MH. Complement in ANCA-associated vasculitis: mechanisms and implications for management. Nat Rev Nephrol. 2017;13(6):359-367. 6. Cui Z, Xie LJ, Chen FJ, Pei ZY, Zhang LJ, Qu Z, Huang J, Gu QH, Zhang YM, Wang X, Wang F, Meng LQ, Liu G, Zhou XJ, Zhu L, Lv JC, Liu F, Zhang H, Liao YH, Lai LH, Ronco P, Zhao MH. MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy. J Am Soc Nephrol. 2017;28(5):1651-1664. 7. Yu JT, Li JN, Wang J, Jia XY, Cui Z, Zhao MH. Deglycosylation of myeloperoxidase uncovers its novel antigenicity. Kidney Int. 2017;91(6):1410-1419. 8. Yu F, Haas M, Glassock R, Zhao MH. Redefining lupus nephritis: clinical implications of pathophysiologic subtypes. Nat Rev Nephrol. 2017;13(8):483-495. 9. Wang F, Yang C, Long J, Zhao X, Tang W, Zhang D, Bai K, Su Z, Gao B, Chu H, Wang J, Sun X, Wang S, Zuo L, Wang Y, Yu F, Wang H, Zhang L, Zhao MH. Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET). Kidney Int. 2019;95(3):501-505. 10. Wang HY, Cui Z, Pei ZY, Fang SB, Chen SF, Zhu L, Chen M, Chen N, Zhao MH. Risk HLA class II alleles and amino acid residues in myeloperoxidase-ANCA-associated vasculitis. Kidney Int. 2019;96(4):1010-1019