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个人简介

教育背景 学士学位(MD) 1977.3-1980.1 中国吉林医学院临床医学 硕士学位(MSc) 1985.5-1988.6 中国北京大学医学部免疫学 博士学位(PhD) 1991.9-1994.4 英国伦敦大学国家心肺研究所呼吸病学 工作经历 集体户户长 1974.6-1977.2 中国 吉林省永吉县口前青年果树队(插队) 助教 1980.1-1985.4 中国 吉林医学院微生物与免疫学系 讲师 1988.7-1989.9 中国 北京大学医学部免疫学系 访问学者 1989.1-1991.8 英国 伦敦国家心肺研究所 博士后 1994.5-1995.12 英国 伦敦帝国学院医学院、国家心肺病学系 讲师 1996.1-2002.3 英国 伦敦帝国学院医学院,国家心肺病学系 免疫学首席研究员兼免疫部主任 2002.4-2003.3 中国台湾 太景生物科技有限公司 高级讲师 2003.4-2008.8 英国 伦敦国王学院 教授 2008.8-2014.9 英国 伦敦国王学院 兼任教授 2014.9-至今 英国 伦敦国王学院 教授 2014.9-至今 中国 首都医科大学基础医学院 奖励 [1] 2012年“北京市海外高层次人才”短期项目专家 [2] 2006年获皇家学会国际旅行基金 [3] 2004年获英国过敏临床免疫学会国际旅行基金 [4] 1999年获皇家学会国际旅行基金 [5] 1995年获美国过敏学会国际旅行基金 [6] 1995年获法玛西亚青年奖学金 [7] 1994年获美国过敏学会国际旅行基金 [8] 1993年获美国过敏学会国际旅行基金

研究领域

主要从事呼吸系统过敏性疾病的临床免疫学研究工作,包括呼吸系统的细胞和分子免疫学,细胞因子的免疫调控机制研究等。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Li C, Ma X, Tan C, Fang H, Sun Y, Gai X. IL-17F expression correlates with clinic opathologic factors and biological markers in non-small cell lung cancer. Pathol Res Pract. 2019 Oct;215(10):152562. doi: 10.1016/j.prp.2019.152562. Epub 2019 Jul 31. 2. Gao An, Wenjun Wang, Xin Zhang, Qiong Huang, Qin Li, Shihao Chen, Xiaonan Du, Chris J Corrigan, Kewu Huang, Wei Wang, Yan Chen, and Sun Ying. Combined blockade of IL-25, IL-33 and TSLP mediates amplified inhibition of airway inflammation and remodelling in a murine model of asthma. Respirology. 2019 Oct 14. doi: 10.1111/resp.13711. [Epub ahead of print]. 3. Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metab. 2019 Oct 1;30(4):675-688.e7. doi: 10.1016/j.cmet.2019.08.018. Epub 2019 Sep 19. 4. Li M, Zhao W, Wang Y, Jin L, Jin G, Sun X, Wang W, Wang K, Xu X, Hao J, Jin R, Fu W, Sun Y, Chang Y, Huang X, Zhou X, Wu H, Zhang K, Ge Q. A wave of Foxp3+ regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance. Cell Mol Immunol. 2019 Jun 6. doi: 10.1038/s41423 -019-0246-9. [Epub ahead of print] 5. Li Q, Hu Y, Chen Y, Lv Z, Wang J, An G, Du X, Wang H, Corrigan CJ, Wang W, Ying S. IL-33 induces production of autoantibody against autologous respiratory epithelial cells: a potential mechanism for the pathogenesis of COPD. Immunology. 2019 Feb 23. doi: 10.1111/imm.13054. [Epub ahead of print] (Corresponding author) 6. Guo Y, Ying S, Zhao X, Liu J, Wang Y. Increased expression of lung TRPV1/ TRPA1 in a cough model of bleomycin-induced pulmonary fibrosis in Guinea pigs. BMC Pulm Med. 2019 Feb 4;19(1):27. doi: 10.1186/s12890-019-0792-z. 7. Li Y, Chen S, Chi Y, Yang Y, Chen X, Wang H, Lv Z, Wang J, Yuan L, Huang P, Huang K, Corrigan CJ, Wang W, Ying S. Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma: a potential role for the chemokine CXCL16. Cell Mol Immunol. 2019;16(1):86-97. (Co-Corresponding author) 8. Huang Q, Ma XC, Yang X, Wang W, Li Y, Lv Z, Corrigan CJ, Chen Y, Ying S Expression of IL-17A, E, and F and their receptors in non-small-cell lung cancer. J Biol Regul Homeost Agents. 2018 Sep-Oct;32(5):1105-1116. 9. Wang W, Li Y, Lv Z, Chen Y, Li Y, Huang K, Corrigan CJ, Ying S. Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa. J Immunol. 2018 Sep 5. pii: ji1800709. doi:10.4049/jimmunol.1800709. [Epub ahead of print] (Corresponding author) 10. Liu J, Wang W, Wang L, Chen S, Tian B, Huang K, Corrigan CJ, Ying S, Wang W, Wang C. IL-33 Initiates Vascular Remodelling in Hypoxic Pulmonary Hypertension by up-Regulating HIF-1α and VEGF Expression in Vascular Endothelial Cells. EBioMedicine. 2018 Jul;33:196-210. doi: 10.1016/j.ebiom.2018.06.003. 11. Li Y, Wang W, Lv Z, Li Y, Chen Y, Huang K, Corrigan CJ, Ying S. Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease. J Immunol. 2018, 200(7): 2253-2262. (Corresponding author) 12. An G, Zhang X, Wang W, Huang Q, Li Y, Shan S, Corrigan CJ, Wang W, Ying S The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma. Immunology. 2018 Feb 18. doi: 10.1111/imm.12911 (Corresponding author) 13. Slovick A, Douiri A, Muir R, Guerra A, Tsioulos K, Hay E, Lam EPS, Kelly J, Peacock JL, Ying S, Shamji MH, Cousins DJ, Durham SR, Till SJ. Intradermal grass pollen immunotherapy increases TH2 and IgE responses and worsens respiratory allergic symptoms. J Allergy Clin Immunol. 2017;139(6):1830-1839. 14. Gao N, Wang Y, Zheng CM, Gao YL, Li H, Li Y, Fu TT, Xu LL, Wang W, Ying S, Huang K. β2-Microglobulin participates in development of lung emphysema by inducing lung epithelial cell senescence. Am J Physiol Lung Cell Mol Physiol. 2017,312(5):L669-L677. 15.Feng ZH, Li Q, Liu SR, Du XN, Wang C, Nie XH, Wang W, Ying S. Comparison of Composition and Diversity of Bacterial Microbiome in Human Upper and Lower Respiratory Tract. Chin Med J (Engl). 2017, 130(9):1122-1124. 16. Ting Yang, Yan Li, Zhe Lyu, Kewu Huang, Chris J Corrigan, Sun Ying, Wei Wang, Chen Wang. Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics: Relationships with Disease Severity and Infiltration of Inflammatory Cells. Chin Med J (Engl). 2017, 130(17): 2033-2047. 17. Siew LQ, Wu SY, Ying S, Corrigan CJ. Cigarette smoking increases bronchial mucosal IL-17A expression in asthmatics, which acts in concert with environmental aeroallergens to engender neutrophilic inflammation. Clin Exp Allergy. 2017 Feb 17. doi: 10.1111/cea.12907. [Epub ahead of print] 18. Huang P, Li Y, Lv Z, Wang J, Zhang Q, Yao X, Corrigan CJ, Huang K, Wang W, Ying S. Comprehensive attenuation of IL-25-induced airway hyperresponsiveness, inflammation and remodelling by the PI3K inhibitor LY294002. Respirology. 2017, 78-85. (Corresponding author) 19. Pillai P, Chan YC, Wu SY, Ohm-Laursen L, Thomas C, Durham SR, Menzies-Gow A, Rajakulasingam RK, Ying S, Gould HJ, Corrigan CJ. Omalizumab reduces bronchial mucosal IgE and improves lung function in non-atopic asthma. Eur Respir J. 2016,48(6):1593-1601. 20. Samitas K, Poulos N, Semitekolou M, Morianos I, Tousa S, Economidou E, Robinson DS, Kariyawasam HH, Zervas E, Corrigan CJ, Ying S, Xanthou G, Gaga M.Activin-A is overexpressed in severe asthma and is implicated in angiogenic processes. Eur Respir J. 2016,47(3):769-82.

学术兼职

理事 2014-至今 中国中国免疫学会 理事 2014-至今 中国北京免疫学会 全英华人生命科学学会理事 世界中医药学会联合会老年医学专业委员会理事 美国哮喘、过敏和免疫学学会委员 英国过敏和临床免疫学学会委员 Journal of Allergy and Clinical Immunology, American Journal of Respiratory and Critical Care Medicine, Journal Immunology, American Journal of Physiology-Lung Cellular and Molecular Physiology, J Investigative Dermatology, Thorax, Allergy, Clinical and Experimental Allergy, Clinical and Experimental Immunology, European Respiratory Journal, Int Arch Allergy, Experimental Cell Research, Acta Pharmacology Sinica等杂志的评阅人 英国MRC, Welcome Trust, 新西兰Royal Society of New Zealand, 法国Fondation Recherche Mediale, DEFIS DE LA Recherche En ALLERGOLYIE, French, 香港Research Grant Council Of Hong Kong等基金的评委

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