Sampson, Nicole S. - Stony Brook University

个人简介

B.S. Harvey Mudd College, 1985 Ph.D. University of California, Berkeley, 1990 American Cancer Society Postdoctoral Fellowship, Harvard University, 1991-1993

研究领域

The research in our laboratory focuses on understanding the relationship between protein structure and protein function and synthesizing chemical tools to probe and control biological function. Work is ongoing in five different areas: AROMP Cancer Metastasis Lipid-Protein Interactions Mammalian Fertilization Tuberculosis Steroid Metabolism

近期论文

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Kreit, J; Sampson, N. S. (2009) "Cholesterol oxidase: Physiological functions," FEBS, 276, 6844-6856. PMC2805774. – Invited Review. [abstract] Lyubimov, A. Y.; Chen, L.; Sampson, N. S.; Vrielink, A. (2009) "A hydrogen-bonding network is important for oxidation and isomerization in the reaction catalyzed by cholesterol oxidase," Acta Crys. D, 65, 1222-1231. PMC3089011. Nesbitt, N. M.; Fontán, P.; Kolesnikova, I.; Smith, I.; Sampson, N. S.; Dubnau, E. (2010) "A thiolase of M. tuberculosis is required for virulence and for production of androstenedione and androstadienedione from cholesterol," Infect. Immun., 78, 275-282. PMC2798224 Dufour, A.; Sampson, N. S.; Kuscu, C.; Zucker, S.; Cao, J. (2010) "Role of MMP-9 dimers in cell migration: design of inhibitor peptides," J. Biol. Chem., 285, 35944-35956. 10.1074/jbc.M109.091769. PMC2975217. Song, A.; Lee, J.; Parker, K. A.; Sampson, N. S. (2010) "Scope of the ring opening metathesis polymerization (ROMP) reaction of 1-substituted cyclobutenes," J. Am. Chem. Soc., 132, 10513–10520. 10.1021/ja1037098. PMC2718539. http://pubs.acs.org/doi/full/10.1021/ja1037098 Song, A.; Parker, K. A.; Sampson, N. S. (2010) "Cyclic alternating ROMP (CAROMP). Rapid access to functionalized cyclic polymers," Org. Lett., 12, 3729-3731. 10.1021/ol101432m. PMC2933648. Yang, X.; Gao, J.; Smith, I.; Dubnau, E.; Sampson, N. S. (2011), "Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection," J. Bact., 193, 1473-1476. 10.1128/JB.01210-10. PMC3067635 Song, A.; Walker, S. G.; Parker, K. A.; Sampson, N. S. (2011) "Antibacterial studies of alternating, random and homo-polymers with varied positions of cationic side chains," ACS Chem. Biol., 6, 590-599. doi: 10.1021/cb100413w PMC3117943 Thomas, S.; Yang, X.; Sampson, N. S. (2011), "Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids," Bioorg. Med. Chem. Lett., 21, 2216-2219. 10.1016/j.bmcl.2011.03.004 PMC3077731 Dufour, A.; Sampson, N. S.; Rizzo, R; DeLeon, J; Li, J; Kuscu, C.; Zhi, J.; Jaber, N.; Liu, E.; Zucker, S.; Cao, J. (2011) "Small molecule anti-cancer therapy selectively targets the hemopexin domain of matrix metalloproteinase-9 (MMP-9)," Cancer Res., 71, 4977-4988. 10.1158/0008-5472 PMC3138841 Zarrabi, K.; Dufour, A.; Li, J; Kuscu, C.; Kozarekar, P.; Zhi, J.; Sampson, N. S.; Zucker, S.; Cao, J. (2011) "Inhibition of matrix metalloproteinase-14 (MMP-14)-mediated cancer cell migration," J. Biol. Chem., 286, 38, 33167-77. DOI: http://dx.doi.org/10.1074/jbc.M111.256644 Thomas, S.T., VanderVen, B.C., Sherman, D.R., Russell, D.G., Sampson, N.S. "Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism," J. Biol. Chem, (2011), 286, 51, 43668-78. DOI: 10.1074/jbc.M111.313643 Ueki, N. Lee, S. Sampson, N. S., Hayman, M. J. (2013) "Selective cancer targeting with prodrugs activated by histone deacetylase and tumour-associated protease," Nature Comm., 4, 2735-2742. DOI: 10.1038/ncomms3735 Slayden, R.A., Jackson, M., Zucker, J., Ramirez, M.V., Dawson, C.C., Crew, R., Sampson, N.S., Thomas, S.T., Jamshidi, N., Sisk, P., Caspi, R., Crick, D.C., McNeil, M.R., Pavelka, M.S., Niederweis, M., Siroy, A., Dona, V., McFadden, J., Boshoff, H., Lew, J.M. (2013) "Updating and curating metabolic pathways of TB," Tuberculosis, 93, 1, 47-59. DOI: 10.1016/j.tube.2012.11.001 Thomas, S.T., Sampson, N.S. "Mycobacterium tuberculosis utilizes a unique heterotetrameric structure for dehydrogenation of the cholesterol side chain," Biochemistry, (2013), 52, 17, 2895-904. DOI: 10.1021/bi4002979 Evensen N.A., Li J., Yang J., Yu X., Sampson N.S., Zucker, S., Cao, J. (2013) "Development of A High-throughput Screening Invasion Assay for Anti-Cancer Drug Discovery," PLoS One, 8(12): e82811. DOI: 10.1371/journal.pone.0082811 Wu, L., and Sampson, N. S. (2014) "Fucose, Mannose and β-N-Acetylglucosamine Glycopoly-mers Initiate the Mouse Sperm Acrosome Reaction Through Convergent Signaling Pathways," ACS Chem. Biol. 9, 468-475 DOI: 10.1021/cb400550j Gao, J. and Sampson, N. S. (2014) "A GMC Oxidoreductase Homolog is Required for Acetylation of Glycopeptidolipid in Mycobacterium smegmatis," Biochemistry 53, 611-613 DOI: 10.1021/bi4015083 Wipperman, M., Sampson, N. S., and Thomas, S. T. (2014) "Pathogen "Roid Rage": Cholesterol Utilization by Mycobacterium tuberculosis," CRC Critical Reviews in Biochemistry, DOI 10.3109/10409238.2014.895700. Tan, L., Parker, K., and Sampson, N. S. (2014) "A Bicyclo[4.2.0]octene-derived monomer provides completely linear alternating copolymers via alternating ring-opening metathesis polymerization (AROMP)," Macromolecules, DOI: 10.1021/ma5012039 Yang, M., Guja, K. E., Thomas, S. T., Garcia-Diaz, M. And Sampson, N. S. (2014) "A distinct MaoC-like enoyl-CoA hydratase architecture mediates cholesterol catabolism in Mycobacterium tuberculosis," ACS Chemical Biology, in press. DOI:10.1021/cb500232h