个人简介
1986/8-1991/8: 南京铁道医学院医疗系 学士学位
1991/8-1993/8: 北京铁路总医院外科 住院医师
1993/8-1998/8: 上海第二医科大学 博士学位
1998/8-2001/5: 上海第二医科大学附属第九人民医院整形外科 主治医师
2001/5-2005/6: 上海第二医科大学附属第九人民医院整形外科 副主任医师
2003/1 -2012/12: 上海组织工程研究与开发中心 副主任
2004/1-2010/1: 组织工程国家工程研究中心 常务副主任,教授、博士生导师
2006/1-2014/12: 上海交通大学医学院附属第九人民医院整形外科 研究员
2014/12-至今: 同济大学医学院再生医学系 教授、博导
2015/5-至今: 首都医科大学附属北京世纪坛医院 中心实验室 主任,教授、博导
2017/5-至今: 首都医科大学附属北京世纪坛医院整形外科 代理主任
获奖情况
1. 组织工程化组织构建关键技术研发与应用 国家技术发明二等奖(2008) 第2完成人
2. 干细胞构建组织工程骨的基础研究与临床应用 教育部科技进步二等奖(2008) 第1完成人
3. 基于组织工程化角膜基质构建的角膜缺损修复研究 上海医学科技奖二等奖(2006) 第1完成人
4. 组织工程皮肤的基础和应用研究 上海医学科技奖二等奖(2005) 第3完成人
5. 组织工程化肌腱的应用基础研究 上海市科技进步一等奖(2004) 第3完成人
6. 修复骨组织缺损的组织工程学基础与临床应用研究 中华医学科技奖三等奖(2003) 第2完成人
研究领域
从事整形外科临床、干细胞与组织工程研究、临床应用转化等工作。
近期论文
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1. Zhang K,Song L,Wang J,Yan S,Li G,Cui L#,Yin J. Strategy for constructing vascularized adipose units in poly(lglutamicacid) hydrogel porous scaffold through inducing in-situ formation of ASCs spheroids. Acta Biomater.2017;51:246-257.
2. Xue X,Liu Y,Wang Y,Meng M,Wang K,Zang X,Zhao S,Sun X,Cui L#,Pan L,Liu S.MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1,SOCS6,and PTEN. Oncotarget. 2016 ;7(51):84508-84519.(co-correspondence)
3. Yan S,Zhang X,Zhang K,Di H,Feng L,Li G,Fang J,Cui L#,Chen X,Yin J. Injectable in situ forming poly(Lglutamicacid) hydrogels for cartilage tissue engineering. J. Mater. Chem. B,2016;4: 947-961. (co-correspondence)
4. Zhang K,He S,Yan S,Li G,Zhang D,Cui L#,Yin J. Regeneration of hyaline-like cartilage and subchondral bone simultaneously by poly- (L-glutamic acid) based osteochondral scaffolds with induced autologous adipose derived stem cells. J. Mater. Chem. B,2016;4: 2628-2645. (co-correspondence)
5. Kaisaier A,Munila M,Abudusaimi A,Cui L#. Differentiation of human adipose derived stem cells into smooth muscle cells is modulated by CaMKII. Stem Cells International. Stem Cells Int,2016 (19):1-9. (correspondence)
6. Li C,Bi W,Gong Y,Ding X,Guo X,Sun J,Cui L#,Yu Y. Transforming growth factor-beta1 inhibits tissue engineering cartilage absorption via inducing the generation of regulatory T cells. J Tissue Eng Regen Med. 2016;10(2):E113-20.(co-correspondence)
7. Gu H,Huang Z,Yin X,Lu L,Cui L#. Role of c-Jun N-terminal kinase in the osteogenic and adipogenic differentiation of human adipose-derived mesenchymal stem cells. Exp Cell Res. 2015,339(1):112-21.(co- correspondence)
8. Jianjun Fang,Qi Yong,Kunxi Zhang,Wentao Sun,Shifeng Yan,Lei Cui# and Jingbo Yin. Novel injectable porous poly(g-benzyl-L- glutamate) microspheres for cartilage tissue engineering: preparation and evaluation. J. Mater.Chem. B,2015,3,1020–1031
9. Zhang K,Yan S,Li G,Cui L#,Yin J. In-situ birth of MSCs multicellular spheroids in poly(L-glutamic acid)/chitosan scaffold for hyaline-like cartilage regeneration. Biomaterials,2015. 71: p. 24-34.(co-correspondence)
10. Fang J,Zhang Y,Yan S,Liu Z,He S,Cui L,Yin J. Poly(L-glutamic acid)/chitosan polyelectrolyte complex porous microspheres as cell microcarriers for cartilage regeneration. Acta Biomater. 2014 Jan;10(1):276-88.(IF:5.1共同通讯作者)
11. Zhang K,Zhang Y,Yan S,Gong L,Wang J,Chen X,Cui L,Yin J. Repair of an articular cartilage defect using adipose-derived stem cells loaded on a polyelectrolyte complex scaffold based on poly(l-glutamic acid) and chitosan. Acta Biomater. 2013 Jul;9(7):7276-88.(IF:5.1共同通讯作者)
12. Gong L,Zhou X,Wu Y,Zhang Y,Wang C,Zhou H,Guo F,Cui L. Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.Tissue Eng Part A. 2014 Feb;20(3-4):575-87(IF 4.5 通讯作者)
13. Wang C et al,Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.PLoS One. 2014(IF 3.5通讯作者)
14. Zou J,et al. The graft of autologous adipose-derived stem cells in the corneal stromal after mechanic damage.PLoS One.2013 (IF 3.5通讯作者)
15. Liu G,Zhang Y,Liu B,Sun J,Li W,Cui L. Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold. Biomaterials. 2013 Apr;34(11):2655-64..(IF:7.8,通讯作者)
16. Wang C,Guo F,Zhou H,Zhang Y,Xiao Z,Cui L. Proteomic profiling of tissue-engineered blood vessel walls constructed by adipose-derived stem cells. Tissue Eng Part A. 2013 ;19:415-25.(IF:4.5,通讯作者)
17. Shifeng Yan,Kunxi Zhang,Zhiwen Liu,Xin Zhang,Lu Gan,Bin Cao,Xuesi Chen,Lei Cui#and Jingbo Yin. Fabrication of poly(L-glutamic acid)/chitosan polyelectrolyte complex porous scaffolds for tissue engineering. J.Mater. Chem. B,2013,1,1541–1551
18. Xu J,Chen Y,Yue Y,Sun J,Cui L. Reconstruction of epidural fat with engineered adipose tissue from adipose derived stem cells and PLGA in the rabbit dorsal laminectomy model. Biomaterials. 2012 ;33(29):6965-73.(IF:7.8,通讯作者)
19. Chen F,Zhang W,Wu W,Jin Y,Cen L,Kretlow JD,Gao W,Dai Z,Wang J,Zhou G,Liu W,Cui L,Cao Y.Cryopreservation of tissue-engineered epithelial sheets in trehalose. Biomaterials. 2011 Nov;32(33):8426-35.(IF:7.8,通讯作者)
20. Gao WC,Ma SL,Cui L. Adipose-derived stem cells accelerate neovascularization in ischemic diabetic skin flap via expression of hypoxia-inducible factor-1. J Cell Mol Med. 2011;15:2575-85.(IF:4.5,通讯作者)
学术兼职
中国医促会肿瘤整形外科分会常委
中国整形美容协会抗衰老分会 常务理事、副秘书长
中国生物医学工程学会理事
中国整形美容协会抗衰老分会常务理事
“中华医学奖”评审专家