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研究领域

1. 天然药物有效成分的寻找、分离、鉴定及结构改造; 2. 现代中药的研究与开发; 3. 上市药品的质量标准提升和生产工艺改进。

近期论文

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1.Yu-Ming Liu, Jun-Shan Yang, Qing-Hua Liu. A new alkaloid and its artificial derivative with indazole ring from Nigella glandulifera. Chem. Pharm. Bull., 2004, 52 (4): 454-455. 2. Ze Tian, Yu-Ming Liu, Si-Bao Chen, Jun-Shan Yang, Pei-Gen Xiao, Liao Wang, Erxi Wu. Cytotoxicity of two triterpenoids from Nigella glandulifera, Molecules, 2006, 11 (9): 693-699. 3. Yu-Ming Liu, Qing-Hua Liu,Bao-Quan Chen. A new flavonol glycoside from the seeds of Nigella glandulifera. Natural Product Research, 2011, 25 (14):1334-1338. 4. Yu Feng, Yu-Ming Liu*, Qing-Hua Liu,Ying-Jie Lei. Nigelactone, new phthalide glucoside from the seeds Nigella glandulifera. Heterocycles, 2012, 85 (12): 3015-3019. 5. Yu-Ming Liu, Lu Sun, Qing-Hua Liu, Shi-Rong Lu, Bao-Quan Chen. Dolabellane-type diterpene alkaloids from Nigella glandulifera. Biochemical Systematics and Ecology, 2013, 49: 43–46. 6.Yu-Ming Liu, Yu-Hu Jiang, Qing-Hua Liu, Bao-Quan Chen. Indazole-type alkaloids from the seeds of Nigella glandulifera. Phytochemistry Letters, 2013, 6 (4): 556–559. 7.Lu Sun, Yu-Ming Liu*, Bao-Quan Chen, Qing-Hua Liu. New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells. Bioorganic & Medicinal chemistry Letters, 2015, 25 (18): 3864-3866. 8.Yu-Ming Liu, Jian-Bing Nie,Lin-Na Sun,Qing-Hua Liu. Cytotoxic compounds from Scolopendra subspinipes mutinlans. Heterocycles, 2016, 92 (2): 346-352. 9.Ying-Li Chen, Chun-Lan Zhou, Zhen-Dan Ge, Yu-Fa Liu, Yu-Ming Liu, Wei-Yi Feng, Sen Li, Guo-You Chen, Tai-Ming Wei.Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense.Oncology Letters, 2013, 6 (4): 1140–1146. 10.Jie Zhao, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Hai-Chuan Zhao, Ji Cheng. Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone. Chin. Chem Lett., 2012, 23 (7): 817-819. 11.Zhen-Hua Luo, Shuang-Yan He, Bao-Quan Chen, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, and Qiu-Sheng Wang. Synthesis and in Vitro Antitumor Activity of 1,3,4-Oxadiazole Derivatives Based on Benzisoselenazolone. Chem. Pharm. Bull., 2012, 60 (7): 887–891. 12.Zhen-Hua Luo, Bao-Quan Chen, Shuang-Yan He, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li. Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives. Bioorg. Med. Chem. Lett., 2012, 22 (9): 3191-3193. 13.Hai-Chuan Zhao, Yan-Ping Shi, Yu-Ming Liu, Cai-Wen Li, Li-Na Xuan, Peng Wang, Kai Zhang, Bao-Quan Chen. Synthesis and antitumor-evaluation of 1,3-selenazole-containing 1,3,4-thiadiazole derivatives. Bioorg. Med. Chem. Lett., 2013, 23 (24): 6577-6579. 14.Jie Zhao, Li-Na Xuan, Hai-Chuan Zhao, Ji Chen, Xiao-Yun Fu, Sha Li, Fen Jing, Yu-Ming Liu, Bao-Quan Chen. Synthesis and antitumor activities of 1,3,4-thiadiazole derivatives possessing benzisoselenazolone scaffold. Chem. Res. Chin. Univ., 2014, 30(5), 764-769. 15.Kai Zhang, Peng Wang, Li-Na Xuan, Xiao-Yun Fu, Fen Jing, Sha Li, Yu-Ming Liu, Bao-Quan Chen. Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety. Bioorg. Med. Chem. Lett., 2014, 24 (22): 5154-5156. 16.Li-Na Xuan, Peng Wang, Kai Zhang, Yan-Ping Shi, Yu-Ming Liu, Tao Zhu, Bao-Quan Chen. Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone derivatives. Med. Chem. Res., 2015, 24 (2): 543-552. 17.Bao-Lin Li, Bo Li, Rui-Lian Zhang, Ji-Jun Zhao, Xue-Feng Wang, Yu-Ming Liu, Yan-Ping Shi, Jin-Biao Liu, Bao-Quan Chen. Synthesis and antiproliferative evaluation of novel 1,2,4-triazole derivatives incorporating benzisoselenazolone scaffold. Bioorg. Med. Chem. Lett., 2016, 26 (4): 1279-1281. 18.史艳萍, 陈宝泉, 麻静, 刘玉明, 李彩文. 2-(2-取代-1,3,4-噻二唑-5-基)-苯并异硒唑-3(2H)-酮衍生物的合成及体外抗癌活性, 化学学报, 2011, 69(21): 2561-2566. 19.刘玉明,梁光义,张建新,武孔云,徐必学,罗波. 马蹄金化学成分的研究.中国药学杂志,2002,37(8):577-579. 20.刘玉明,梁光义,徐必学. 苗族药马蹄金化学成分的研究.天然产物研究与开发,2003,15(1):15-17.

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