王婧 - 中国科学院上海有机化学研究所 -

个人简介

2001年9月~ 2005年7月，四川大学化学学院，获理学学士学位。 2005年9月~ 2010年6月，中国科学技术大学生命科学学院，获哲学博士学位。 2010年7月~ 2016年1月，美国Scripps研究所，助理研究员。 2016年1月~至今，中国科学院上海有机化学研究所研究员

研究领域

结构指导的靶向自噬反应主要调控因子TFEb的药物设计；高通量小分子药物筛选恶性皮肤癌靶向蛋白MITF抑制剂

近期论文

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1. Wang J, Fang P, Bennett S, Dai J, Fisher D, Guo M. Structural Modularity of Microphathalimia-associated Transcription Factor in Melanoma. 2016. 2.Wang J, Fang P, Chen X, Guo M. Ap4A induced tetramer forming regulates tumor suppressor function of Hint1. 2016. 3.Wang J, Spicer T, Hodder P, Guo M. High throughput screening development for directly targeting a transcription factor. 2016. 4.Wang J, Gossing M, Fang P, Zimmermann J, Li X, von Mollard GF, Niu L, Teng M. Epsin N-terminal homology domains bind on opposite sides of two SNAREs. Proc Natl Acad Sci U S A. 2011 Jul 26; 108 (30): 12277-82. 5.Wang J, Fang P, Schimmel P, Guo M. Side Chain Independent Recognition of Aminoacyl-Adenylates by the Hint1 Transcription Suppressor. Journal of Physical Chemistry, 2012 Jun 14; 116 (23): 6798-805 6.Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M. Structural switch of lysyl-tRNA synthetase function between translation and transcription. Mol. Cell, 2013. 49(1):30-42. 7.Kim DG, Fang P, Wang J, Kang BS, Guo M, Kim S. A genome-destabilizing mutation of AIMP3/p18 at the interface for translational initiation. 2016. 8.Fang P, Wang J, Chen K, Guo, M., Structural adaptation for novel functional regulation through dynamic adjustment in human lysyl-tRNA synthetase. 2016. 9.Kim DG, Lee JY, Kwon NH, Fang P, Zhang Q, Wang J, Young NL, Guo M, Cho HY, Mushtaq AU, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, Hur Y, Kang W, Yang H, Nam DH, Lee MS, Lee JW, Kim ES, Moon A, Kim K, Kim D, Kang EJ, Moon Y, Rhee KH, Han BW, Yang JS, Han G, Yang WS, Lee C, Wang MW, Kim S. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction. Nat Chem Biol. 2014. Jan;10(1):29-34. 10.Fang P, Li X, Wang J, Xing L, Gao Y, Niu L, Teng M. Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli. Cell Biochem Biophys, 2010 Dec;58(3):163-7 11.Fang P, Li X, Wang J, Niu L, Teng M. Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5. Biochemistry, 2010 Sep 14;49(36):7949-55 12.Fang P, Wang J, Li X, Guo M, Xing L, Cao X, Zhu Y, Gao Y, Niu L, Teng M. Crystallization and preliminary X-ray analysis of Escherichia coli RNase G. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Jun 1;65(Pt 6):586-8 13.Xing L, Zhu Y, Fang P, Wang J, Zeng F, Li X, Teng M, Li X. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1;67(Pt 6):727-9