王晓明 - 中国科学院上海有机化学研究所 -

个人简介

Education and Work Experience 2005.9-2009.7: B.S. in Chemistry, ZheJiang University, Hangzhou, China. 2009.9-2014.7: Ph.D. in Organic Chemistry, Shanghai Institute of Organic Chemistry. Supervisor: Prof. Kuiling Ding. 2014.9-2018.1: Postdoc research in Münster University, Germany (with Prof. Frank Glorius). 2018.2-2019.3: Postdoc research in University of Tokyo, Japan (with Prof. Kyoko Nozaki). Since 2019.3: Professor, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China. Awards 2020 Thieme Chemistry Journals Award Alexander von Humboldt-Fellowship, Germany (2014) Chinese Academy of Science Excellent PhD Dissertations Chinese Academy of Science Presidential Scholarship (Special Prize) National Scholarship, P.R. China (2013)

研究领域

Understanding the role of metal-metal interaction is an important scientific issue in homogeneous and heterogeneous metal catalysis, such as group transfer and/or electron transfer between metals, synergistic effects, metal aggregation and their deactivation etc. To address these challenges, our group focuses on the study of catalytic systems involving multi-metal species, including the realization of challenging conversions by bimetallic cooperative catalysis, bi (multi)-nuclear metal catalysis and the in-situ aggregation of metal species in catalysis.

近期论文

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Liu, Y.#; Chen, H.#; Wang, X.* J. Am. Chem. Soc. 2024, 10.1021/jacs.4c09983e202307973. Synergistic Homogeneous Asymmetric Cu Catalysis with Pd Nanoparticle Catalysis in Stereoselective Coupling of Alkynes with Aldimine Esters. Lan, Y.; Liu, P.; Fang, Z.; Shao, L.; Cai, Q. L. *; Wang, X.* Org. Chem. Front. 2024, DOI: 10.1039/d4qo01368a. Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives. Wang, Y.; Li, S. -J.; Jiang, F.; Lan, Y.*; Wang, X.*, J. Am. Chem. Soc. 2024, 146, 28, 19286–19294. Making Full Use of TMSCF3: Deoxygenative Trifluoromethylation/Silylation of Amides. Yao, J.; Zhao, C.; Shao, L.; Huo, X.; Wang, X. *, Sci. China Chem. 2024, 67, 2710-2718. Synergistic Asymmetric Diarylation of Tethered Alkenes via C–H Functionalization of Simple (Hetero)Arenes. Deng, X.; Jiang, F.*; and Wang, X.*, Org. Lett. 2024, 26, 2483–2488. Asymmetric Deoxygenative Functionalization of Secondary Amides with Vinylpyridines Enabled by a Triple Iridium-Photoredox-Chiral Phosphoric Acid System. Chen, H.; Yang, W.; Zhang, J.; Lu, B.; Wang, X.*, J. Am. Chem. Soc. 2024, 146, 7, 4727–4740. Divergent Geminal Alkynylation−Allylation and Acylation−Allylation of Carbenes: Evolution and Roles of Two Transition-Metal Catalysts. Yao, J.; Shao, L.; Kang, X.; Zhu, M.; Huo, X.*; Wang, X.*, J. Org. Chem. 2024, 89, 3, 1719–1726. Direct α-arylation of benzo[b]furans catalyzed by Pd3 cluster. Chen, K#.; Zhu, H#.; Li, S.; Bai, J.; Guo, Y.; Ding, K.*; Peng, Q.*; Wang, X.*, J. Am. Chem. Soc. 2023, 145, 24877–24888. Switch in Selectivities by Dinuclear Nickel Catalysis: 1,4-Hydroarylation of 1,3-Dienes to Z-Olefins. Li, J.; He, Y.; Jiang, F.*; Wang, X.*, Green Chem. 2023, 25, 9080-9085. Deoxygenative Arylation of Secondary Amides by Merging Iridium Catalysis with Electrochemical Radical Cross-coupling. Cai, Q.; Rao, H.; Li, S. -J.; Lan, Y.*; Ding, K.*; Wang, X.*, Chem 2024, 10, 265-282. Well-defined chiral dinuclear copper complexes in enantioselective propargylic substitution: For a long-standing supposition on binuclear mechanism. Yao, J.; Shao, L.; Huo, X.*; Wang, X.*, Sci. China Chem. 2023, 67, 882-889. Synergistic Silver-mediated and Palladium-catalyzed Nondirected Olefination of Aryl C–H Bond: Quick Access to Multi-substituted Aryl Olefins. Xu, J.; Ge, Z.; Ding, K.; Wang, X.*, JACS Au, 2023, 3, 2862–2872. Rh(II)/Pd(0) Dual-Catalyzed Regio-Divergent Three-Component Propargylic Substitution. Zhao, C; Ge, Z.; Hu, J.; Tian, H.; Wang, X.*, Cell Rep. Phys. Sci. 2023, 4, 101474. Enantioselective reductive aryl-benzylation of alkenes by a nickel-titanium bimetallic system. Wang, G. -Y.; Ge, Z.; Ding, K,; Wang, X.*, Angew. Chem. Int. Ed. 2023, e202307973. Cooperative Bimetallic Catalysis via One-Metal/Two-Ligands: Mechanistic Insights of Polyfluoroarylation-Allylation of Diazo Compounds. Xiao, X.; Xu, K.; Gao, Z.; Zhu, Z.; Ye, C.; Zhao, B.*; Luo, S.*; Ye, S.*; Zhou, Y.*; Xu, S.*; Zhu, S.*; Bao, H.*; Sun, W.*; Wang, X.*; Ding, K.*, Sci. Chi. Chem. 2023, 66, 1553–1633. Biomimetic asymmetric catalysis. Jiang, F.; Li, J.; Wang, X.*, Chem. Eur. J. 2023, e202301199. Deoxygenative Radical Boration of Inert Amides via a Combination of Relay and Cooperative Catalysis. Tian, H.; Zhang, R.; Shi, L.; Zhao, C.*; Wang, X.*, Chin. J. Chem. 2023, 41, 1783-1790. Divergent Synthesis of Organofluorinated Molecules from Titanium Mediated Deoxygenation of Free Alcohols. Liu, S.; Zou, L.*; Wang, X.*, Chin. J. Org. Chem. 2023, 43, 1713-1725. The Advance of Dehydrogenation and Transfer Hydrogenation of Ammonia-Borane Catalyzed by Homogeneous Cobalt Complexes. Yang, W.; Jiao, J.; Wang, X.*, Chin. J. Org. Chem. 2023, 43, 1857-1867. Merging Electron Transfer Activation with 1,2-Metalate Migration: Deoxygenative Silylation of Amides. Yao, J.; Bai, J.; Kang, X.; Zhu, M.; Guo, Y.*; Wang, X.*, Nanoscale 2023, 15, 3560-3565. Non-directed C–H arylation of electron-deficient arenes by synergistic silver and Pd3 cluster catalysis. Ge, Z.; Lu, B.; Teng H.*; Wang, X.*, Chem. Eur. J. 2023, 29, e202202820. Efficient Synthesis of Diaryl Quaternary Centers by Rh(II)/Xantphos Catalyzed Relay C-H Functionalization and AllylicAlkylation. (Highlighted by Synfacts 2023, 19, 0038) Jiao, J.; Yang W.; Wang, X.*, J. Org. Chem. 2023, 88, 594–601. α-Aminocarbene-Mediated Si–H Insertion: Deoxygenative Silylation of Aromatic Amides with Silanes. Zhang, J.#; Lu, B.#; Ge, Z.; Wang, L.*; Wang, X.*, Org. Lett. 2022, 24, 8423–8428. Selective Construction of All-Carbon Quaternary Centers via Relay Catalysis of Indole C-H Functionalization/Allylic Alkylation. (#contributed equally to this work) Wang, Y.; Shao, Y.; Xue, X.*; Wang, X.*, Cell Rep. Phys. Sci. 2022, 3, 101116. Incorporation of Germanium into Amines via Deoxygenative Germylation of Aromatic Amides with Hydrogermanes. Li, F.; Lu, B.; Liu, Y.*; Wang, X.*, Chin. J. Org. Chem. 2022, 42, 3390–3397. Dirhodium/Xantphos-Catalyzed Tandem C-H Functionalization/Allylic Alkylation: Direct Access to 3-Acyl-3-Allyl Oxindoles Derivatives from N-Aryl-α-Diazo-β-Keto Amides. Zhao, F.#; Jiang, F.#; Wang, X.*, Sci. China Chem. 2022, 65, 2231–2237. Deoxygenative Alkylation of Tertiary Amides Using Alkyl Iodides under Visible Light(#contributed equally to this work). (Included in 2022 Emerging Investigator Issue of Science China Chemistry) Liu, T.#; Li, C.#; Bai, J.; Zhang, P.*; Guo, Y.*; Wang,X.*, Chin. J. Chem. 2022, 40, 2203-2211. Markovnikov-Selective Hydroboration of Aryl Alkenes Enabled by a Simple Nickel Salt (#contributed equally to this work). Jiang, F.#; Zhao, F.#; He Y.; Luo, X.; Wang, X.*, Cell Rep. Phys. Sci. 2022, 3, 100955. Efficient Synthesis of β-Substituted Amines via Combining Deoxygenation of Amides with Photochemical Organocatalysis (#contributed equally to this work). Zhang, J.#; Liu, T.#; Wang, L.*; Wang, X.*, Chin. J. Org. Chem. 2022, 42, 2331-2341. Recent Process in the in situ Generated Metal Nanocluster Catalysis (#contributed equally to this work, review, in Chinese). Yang, Y.#; Lu, B.#; Xu,G.*; Wang, X.*, ACS Cent. Sci. 2022, 8, 581-589. Overcoming O-H Insertion to Para-Selective C-H Functionalization of Free Phenols: Rh(II)/Xantphos Catalyzed Geminal Difunctionalization of Diazo Compounds (#contributed equally to this work). He, Y.; Wang, Y.; Li, S. J.; Lan, Y.*; Wang, X.*, Angew.Chem. Int. Ed. 2022, e202115497. Deoxygenative Cross-Coupling of Aromatic Amides with Polyfluoroarenes. Ma, S.; Li, F.; Zhang, G.*; Shi, L.*; Wang, X.*, ACS Catal. 2021, 11, 14848-14853. Highly Regioselective Difluoroalkylarylationof Butadiene through a Nickel-Catalyzed Tandem Radical Process. Chen, K.#; Zhu, H.#; Li, Y.; Peng, Q.*; Guo, Y.*; Wang, X.*, ACS Catal. 2021, 11, 13696-13705. Dinuclear Cobalt Complex-Catalyzed Stereodivergent Semireduction of Alkynes: Switchable Selectivities Controlled by H2O. (#contributed equally to this work). Li, Z.; Zhao, F.; Ou, W.; Huang, P. -Q.*; Wang, X.*, Angew. Chem. Int. Ed. 2021, 60, 26604-26609. Asymmetric Deoxygenative Alkynylation of Tertiary Amides Enabled by Iridium/Copper Bimetallic Relay Catalysis. Song, S.; Li, C.; Liu, T.; Zhang, P.*; Wang, X.*, Org. Lett. 2021, 23, 6925-6930. H-BPin/KOtBu Promoted Activation of Cobalt Salt to a Heterotopic Catalystfor Highly Selective Cyclotrimerization of Alkynes. Lu, B.; Liang, X.; Zhang, J.; Wang, Z.; Peng, Q.*; Wang, X.*, J. Am. Chem. Soc. 2021, 143, 11799-11810. Dirhodium(II)/Xantphos-Catalyzed Relay Carbene Insertion and Allylic Alkylation Process: Reaction Development and Mechanistic Insights. Li, C.; Song, S.; Li, Y.; Xu, C.; Luo, Q.; Guo, Y.*; Wang, X.*, Nat. Commun. 2021, 12, 3813-3820. Selective hydroboration of unsaturated bonds by an easily accessible heterotopic cobalt catalyst. Jiao, J.; Wang, X.*, Angew. Chem. Int. Ed. 2021, 60, 17088-17093. Merging Electron Transfer with 1,2-Metalate Rearrangement: Deoxygenative Arylation of Aromatic Amides with Arylboronic Esters. He, Y.; Wang, X.*, Org. Lett. 2021, 23, 225-230. Synthesis of Cyclic Amidines by Iridium-Catalyzed Deoxygenative Reduction of Lactams and Tandem Reaction with Sulfonyl Azides.