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个人简介

教育背景 2004-09--2009-07 中国科学院上海有机化学研究所 博士 2000-09--2004-06 南京大学 学士 工作简历 2015-04~2016-05,哈佛医学院Dana-Farber癌症研究所, Research Scientist 2010-04~2015-03,哈佛医学院Dana-Farber癌症研究所, 博士后 2009-07~2009-12,中国科学院上海有机化学研究所, 助理研究员

研究领域

谭立课题组致力于对癌症、炎症或神经退行性疾病背景下异常的蛋白质稳态进行化学干预:针对E3泛素连接酶和去泛素化酶等潜在治疗靶点研制首创型调控剂;基于新型共价反应官能团和化学蛋白质组学技术研制新型的共价抑制剂;针对RIPK1所介导的炎症和细胞死亡相关疾病进行新药创制。

近期论文

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Ying Qin, Dekang Li, Chunting Qi, Huaijiang Xiang, Huyan Meng, Jingli Liu, Shaoqing Zhou, Xinyu Gong, Ying Li, Guifang Xu, Rui Zu, Hang Xie, Yechun Xu, Gang Xu, Zheng Zhang, Shi Chen, Lifeng Pan, Ying Li, Li Tan. Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. ACTA PHARMACEUTICA SINICA B[J]. 2024, 第 19 作者 通讯作者 14(1): 319-334, http://dx.doi.org/10.1016/j.apsb.2023.10.021. Tao, Youqi, Xia, Wencheng, Zhao, Qinyue, Xiang, Huaijiang, Han, Chao, Zhang, Shenqing, Gu, Wei, Tang, Wenjun, Li, Ying, Tan, Li, Li, Dan, Liu, Cong. Structural mechanism for specific binding of chemical compounds to amyloid fibrils. NATURE CHEMICAL BIOLOGY. 2023, 第 10 作者http://dx.doi.org/10.1038/s41589-023-01370-x. Wang, Jingyao, Zhou, Shaoqing, Cheng, Yan, Cheng, Lin, Qin, Ying, Zhang, Zhenfeng, Bi, Aiwei, Xiang, Huaijiang, He, Xinheng, Tian, Xiaoxu, Liu, Wenbin, Zhang, Jian, Peng, Chao, Zhu, Zhengjiang, Huang, Min, Li, Ying, Zhuang, Guanglei, Tan, Li. Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 第 18 作者 通讯作者 66(4): http://dx.doi.org/10.1021/acs.jmedchem.2c01563. Lin, Lifeng, Shi, Kaixuan, Zhou, Shaoqing, MeiChun Cai, Zhang, Caiyan, Sun, Yunheng, Zang, Jingyu, Cheng, Lin, Ye, Kaiyan, Ma, Pengfei, Shen, Peiye, Zhang, Meiying, Cheng, Yan, Qi, Chunting, Li, Ying, Yin, Xia, Zheng, Yiyan, Tan, Li, Zhuang, Guanglei, Zang, Rongyu. SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer. ONCOGENE[J]. 2022, 第 18 作者 通讯作者 41(12): 1767-1779, http://dx.doi.org/10.1038/s41388-022-02210-3. Guo, Chenchen, Wan, Ruijie, He, Yayi, Lin, ShuHai, Cao, Jiayu, Qiu, Ying, Zhang, Tengfei, Zhao, Qiqi, Niu, Yujia, Jin, Yujuan, Huang, HsinYi, Wang, Xue, Tan, Li, Thomas, Roman K, Zhang, Hua, Chen, Luonan, Wong, KwokKin, Hu, Liang, Ji, Hongbin. Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer. NATURE CANCER[J]. 2022, 第 13 作者3(5): 614-+, http://dx.doi.org/10.1038/s43018-022-00358-1. Zhuang, Guanglei, Chen, Gang, Tan, Li, Tan, Lingli, Shan, Hengyue, Han, Chao, Zhang, Zhenfeng, Shen, Jiali, Zhang, Xiao, Xiang, Huaijiang, Lu, Kuankuan, Qi, Chunting, Li, Ying. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 3 作者 通讯作者 65(20): 13645-13659, http://dx.doi.org/10.1021/acs.jmedchem.2c00408. Cheng, Lin, Zhou, Shichao, Zhou, Shaoqing, Shi, Kaixuan, Cheng, Yan, Cai, MeiChun, Ye, Kaiyan, Lin, Lifeng, Zhang, Zhenfeng, Jia, Chenqiang, Xiang, Huaijiang, Zang, Jingyu, Zhang, Meiying, Yin, Xia, Li, Ying, Di, Wen, Zhuang, Guanglei, Tan, Li. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. CANCER RESEARCH[J]. 2022, 第 18 作者 通讯作者 82(19): 3588-3602, http://dx.doi.org/10.1158/0008-5472.CAN-22-0222. Meng, Huyan, Wu, Guowei, Zhao, Xinsuo, Wang, Anhui, Li, Dekang, Tong, Yilun, Jin, Taijie, Cao, Ye, Shan, Bing, Hu, Shichen, Li, Ying, Pan, Lifeng, Tian, Xiaoxu, Wu, Ping, Peng, Chao, Yuan, Junying, Li, Guohui, Tan, Li, Wang, Zhaoyin, Li, Ying. Discovery of a cooperative mode of inhibiting RIPK1 kinase. CELL DISCOVERY[J]. 2021, 第 18 作者 通讯作者 7(1): Shan, Hengyue, Liu, Jianping, Shen, Jiali, Dai, Jialin, Xu, Gang, Lu, Kuankuan, Han, Chao, Wang, Yaru, Xu, Xiaolong, Tong, Yilun, Xiang, Huaijiang, Ai, Zhiyuan, Zhuang, Guanglei, Hu, Junhao, Zhang, Zheng, Li, Ying, Pan, Lifeng, Tan, Li. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. CELL CHEMICAL BIOLOGY[J]. 2021, 第 18 作者 通讯作者 28(6): 855-+, http://dx.doi.org/10.1016/j.chembiol.2021.04.020. Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G Chen, Nicholas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Lian Xu, Zachary R Hunter, Jinwei Che, Christopher J Patterson, Kirsten Meid, Jorge J Castillo, Nikhil C Munshi, Kenneth C Anderson, Michael Cameron, Sara J Buhrlage, Nathanael S Gray, Steven P Treon. The HCK/BTK inhibitor KIN-8194 is active in MYD88 driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance.. BLOOD[J]. 2021, 第 3 作者http://dx.doi.org/10.1182/blood.2021011405. Pinch, Benika J, Doctor, Zainab M, Nabet, Behnam, Browne, Christopher M, Seo, HyukSoo, Mohardt, Mikaela L, Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D, Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C, Vangos, Nicholas E, Geffken, Ezekiel A, Tan, Li, Ficarro, Scott B, London, Nir, Marto, Jarrod A, Buratowski, Stephen, DhePaganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S. Identification of a potent and selective covalent Pin1 inhibitor. NATURE CHEMICAL BIOLOGY[J]. 2020, 第 17 作者16(9): 979-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442691/. Yin, Xia, Bi, Rui, Ma, Pengfei, Zhang, Shengzhe, Zhang, Yang, Sun, Yunheng, Zhang, Yi, Jing, Ying, Yu, Minhua, Wang, Wenjing, Tan, Li, Di, Wen, Zhuang, Guanglei, Cai, MeiChun. Multiregion whole-genome sequencing depicts intratumour heterogeneity and punctuated evolution in ovarian clear cell carcinoma. JOURNAL OF MEDICAL GENETICS[J]. 2020, 第 11 作者57(9): 605-609, https://www.webofscience.com/wos/woscc/full-record/WOS:000567008800004. Donovan, Katherine A, Ferguson, Fleur M, Bushman, Jonathan W, Eleuteri, Nicholas A, Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D, Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P, Ghobrial, Irene M, Ma, Michelle W, Che, Jianwei, Buhrlage, Sara J, Sim, Taebo, Gray, Nathanael S, Fischer, Eric S. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. CELL[J]. 2020, 第 7 作者183(6): 1714-+, http://dx.doi.org/10.1016/j.cell.2020.10.038. Gu, Jinge, Liu, Zhenying, Zhang, Shengnan, Li, Yichen, Xia, Wencheng, Wang, Chen, Xiang, Huaijiang, Liu, Zhijun, Tan, Li, Fang, Yanshan, Liu, Cong, Li, Dan. Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 9 作者117(49): 31123-31133, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733851/. Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A, Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J, Lee, Virginia M Y, Wagner, Gerhard, Yuan, Junying. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. NATURE[J]. 2020, 第 20 作者587(7832): 133-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000572352700003. Cai, MeiChun, Zhao, Xiaojing, Cao, Min, Ma, Pengfei, Chen, Minjiang, Wu, Jie, Jia, Chenqiang, He, Chunming, Fu, Yujie, Tan, Li, Xue, Xinying, Yu, Zhuang, Zhuang, Guanglei. T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment. JOURNAL OF PATHOLOGY[J]. 2020, 第 10 作者251(2): 147-159, http://dx.doi.org/10.1002/path.5435. Schroeder, Martin, Tan, Li, Wang, Jinhua, Liang, Yanke, Gray, Nathanael S, Knapp, Stefan, Chaikuad, Apirat. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. CELL CHEMICAL BIOLOGY[J]. 2020, 第 2 作者27(10): 1285-+, http://dx.doi.org/10.1016/j.chembiol.2020.07.014. Pinch, Benika, Doctor, Zainab, Browne, Christopher M, Seo, HyukSoo, Nabet, Behnam, Kozono, Shingo, Lian, Xiaolan, Zaidman, Daniel, Daitchman, Dina, London, Nir, Gong, Lu, Manz, Theresa, Chun, Yujin, Tan, Li, Marto, Jarrod, Buratowski, Stephen, DhePaganon, Sirano, Zhou, Xiao, Lu, Kun Ping, Gray, Nathanael S. Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine. CANCER RESEARCH. 2019, 第 14 作者79(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000488279401207. Rao, Suman, Gurbani, Deepak, Du, Guangyan, Everley, Robert A, Browne, Christopher M, Chaikuad, Apirat, Tan, Li, Schroeder, Martin, Gondi, Sudershan, Ficarro, Scott B, Sim, Taebo, Kim, Nam Doo, Berberich, Matthew J, Knapp, Stefan, Marto, Jarrod A, Westover, Kenneth D, Sorger, Peter K, Gray, Nathanael S. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. CELL CHEMICAL BIOLOGY[J]. 2019, 第 7 作者26(6): 818-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000472159700005. Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L, Abraham, Brian J, Kwiatkowski, Nicholas, Buczkowski, Kevin A, Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L, Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, TaeJung, Hong, SookHee, PoudelNeupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J, Watanabe, Hideo, Gray, Nathanael S, Young, Richard A, Wong, KwokKin, Hammerman, Peter S. Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. CANCER DISCOVERY[J]. 2018, 第 25 作者8(1): 59-73, http://dx.doi.org/10.1158/2159-8290.CD-17-0461. Huang, HaiTsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L, Doctor, Zainab M, Buckley, Dennis L, Cho, JoongHeui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D, Li, Ying, Treon, Steven P, Fischer, Eric S, Bradner, James E, Tan, Li, Gray, Nathanael S. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. CELL CHEMICAL BIOLOGY[J]. 2018, 第 18 作者 通讯作者 25(1): 88-+, http://dx.doi.org/10.1016/j.chembiol.2017.10.005. Powell, Chelsea E, Gao, Yang, Tan, Li, Donovan, Katherine A, Nowak, Radoslaw P, Loehr, Amanda, Bahcall, Magda, Fischer, Eric S, Janne, Pasi A, George, Rani E, Gray, Nathanael S. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 3 作者61(9): 4249-4255, https://www.webofscience.com/wos/woscc/full-record/WOS:000432204800033. Bockorny, Bruno, Rusan, Maria, Chen, Wankun, Liao, Rachel G, Li, Yvonne, Piccioni, Federica, Wang, Jun, Tan, Li, Thorner, Aaron R, Li, Tianxia, Zhang, Yanxi, Miao, Changhong, Ovesen, Therese, Shapiro, Geoffrey I, Kwiatkowski, David J, Gray, Nathanael S, Meyerson, Matthew, Hammerman, Peter S, Bass, Adam J. RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade. MOLECULAR CANCER THERAPEUTICS[J]. 2018, 第 8 作者17(7): 1526-1539, https://www.webofscience.com/wos/woscc/full-record/WOS:000437274600016. Weir, Mark C, Shu, Sherry T, Patel, Ravi K, Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S, Smithgall, Thomas E. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS CHEMICAL BIOLOGY[J]. 2018, 第 6 作者13(6): 1551-1559, https://www.webofscience.com/wos/woscc/full-record/WOS:000435746200018.

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