个人简介
2013.5-至今：中国科学院上海有机化学研究所，副研究员
2007.10-2013.5：中国科学院上海有机化学研究所，助理研究员
2005.4-2007.10：中国科学院上海有机化学研究所，研究实习员
2009.9-2012.12：上海医药工业研究院，生物制药部，获博士学位
2002.9-2005.3：浙江大学，化学工程与生物工程学系，获硕士学位
1998.9-2002.7：浙江大学，生物化工系，获学士学位
研究领域
天然产物的生物合成，微生物来源抗生素的组合生物合成
近期论文
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1. Pan HX, Chen ZZ, Shao L, Li JA, Chen JS, Zhu CB, Tang GL*, Chen DJ*. Production of ramoplanin analogues by genetic engineering of Actinoplanes sp. Biotechnol Lett. 2013, 35: 1685-1692
2. Ma HM, Zhou Q, Tang YM, Zhang Z, Chen YS, He HY, Pan HX, Tang MC, Gao JF, Zhao SY, Igarashi Y, Tang GL*. Unconventional origin and hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis. Chem Biol. 2013, 20: 796-805
3. Pan HX, Li JA, Shao L, Zhu CB, Chen JS, Tang GL*, Chen DJ*. Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase involved in the biosynthesis of ramoplanins. Biotechnol Lett. 2013, 35: 107-114
4. He HY#, Pan HX#, Wu LF, Zhang BB, Chai HB, Liu W, Tang GL*. Quartromicin biosynthesis: two alternative polyketide chains produced by one polyketide synthase assembly line. Chem Biol. 2012, 19: 1313-1323 (# co-first authors)
5. Chen YL, Zhao J, Liu W, Gao JF, Tao LM, Pan HX*, Tang GL*. Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators. Gene. 2012, 509: 195-200
6. Jian XH, Pan HX, Ning TT, Shi YY, Chen YS, Li Y, Zeng XW, Xu J, Tang GL*. Analysis of YM-216391 biosynthetic gene cluster and improvement of the cyclopeptide production in a heterologous host. ACS Chem Biol. 2012, 7: 646-651
7. Wang JB, Pan HX, Tang GL*. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. Bioorg Med Chem Lett. 2011, 21: 3320-3323
8. Pan HX, Li JA, He NJ, Chen JY, Zhou YM, Shao L, Chen DJ*. Improvement of spinosad production by overexpression of gtt and gdh controlled by promoter PermE* in Saccharopolyspora spinosa SIPI-A2090. Biotechnol Lett. 2011, 33: 733-739
9. Ding Y, Yu Y, Pan H, Guo H, Li Y, Liu W*. Moving posttranslational modifications forward to biosynthesize the glycosylated thiopeptide nocathiacin I in Nocardia sp. ATCC202099. Mol Biosyst. 2010, 6: 1180-1185
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