刘南 - 中国科学院上海有机化学研究所 -

个人简介

2003/07-2009/11 美国宾夕法尼亚大学博士研究生 2009/12-2010/11 美国宾夕法尼亚大学博士后 2010/12-2012/12 美国霍华德休斯医学院研究助理 2013/02-至今中国科学院生物与化学交叉研究中心研究员、课题组长

研究领域

衰老和与衰老相关的老年病的发生、发展具有极强的内在关联性。为了揭示潜在的内源机制，我们建立了果蝇衰老模型，并首次发现了具有高度序列保守性的单一微小RNA，miR-34，在成体脑组织中的重要功能。利用果蝇RNAi筛选平台和新一代测序技术，我们发现了介导微小RNA加工通路的新基因，并命名为Nibbler；Nibbler的功能进一步夯实了微小RNA在衰老进程中特异性表达、生理功能和对疾病影响“三位一体”的内源整合机制。我们下一步的研究拟在基因组水平上，以成体果蝇主要生理器官为平台，系统研究微小RNA在衰老过程中的表达，序列多样性及生物学功能，以其在分子遗传水平界定新的调控健康衰老的内源机制。同时积极探索将新的发现转化至人衰老和与人衰老相关的疾病研究中来

近期论文

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(1) Liu N, Landreh M, Cao K, Abe M, Hendriks, Jason Kennerdell J, Zhu Y, Wang L and Bonini N (2012). The microRNA miR-34 modulates aging and neurodegeneration in Drosophila. Nature. 15;482(7386):519-23. (Faculty of 1000 selection; Highlight in Nat Rev Neurosci. 2012 Apr;13(4):222. Nat Rev Genet. 2012 Apr;13(4):222. Cell Research 2012 Apr; (1)-3) (2) Liu N*, Abe M*, Sabin LR, Hendriks GJ, Naqvi AS, Yu Z, Cherry S, Bonini NM (2011). The exoribonuclease Nibber controls 3’ end processing of microRNAs in Drosophila. Current Biology. 21(22):1888-93 (*equal contribution; Featured article; Brief in Nat Rev Genet. 2011 Dec;12) (3) Yu J, Fan Y, Liu N, Shan Y, Li X, Zhang Q (2007). Rapid genome evolution in the Pms1 region of rice revealed by comparative sequence analysis. Chinese Science Bulletin. 52:912-921 (4) Liu N and Bonini NM (2006) Hosting neurotoxicity in polyglutamine disease. Cell. 29;127(7):1299-300 (5) Julide B, Liu N; Bonini NM (2006) A new role for microRNA pathways - Modulation of degeneration induced by pathogenic human disease proteins. Cell Cycle. 5:24:2835-2838 (6) Bilen J, Liu N, Burnett BG, Pittman RN and Bonini NM (2006). MicroRNA pathways modulate polyglutamine-induced neurodegeneration. Molecular Cell 6;24(1):157-63. (Faculty of 1000 selection) (7) Pan GJ, Qin BM, Liu N, Scholer HR and Pei DQ (2004). Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation. J Biol Chem. 279, 37013-37020 (8) Cui P, Qin BM, Liu N, Pan GJ and Pei DQ (2004). Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Exp Cell Res. 293, 154-163 (9) Liu N, Shan Y, Wang FP, Xu CG, Peng KM, Li XH and Zhang QF (2001). Identification of an 85-kb DNA fragment containing pms1, a locus for photoperiod-sensitive genic male sterility in rice. Mol Genet Genomics. 266, 271-275 (10) Wang SP, Liu N, Peng KM and Zhang QF (1999) The distribution and copy number of copia-like retrotransposons in rice (Oryza sativa L.) and their implications in the organization and evolution of the rice genome. Proc Natl Acad Sci. 96, 6824-68