郭敏 - 中国科学院上海有机化学研究所 -

个人简介

1996-2000 中国中国科学技术大学本科 2000-2005 中国中国科学技术大学博士 2005-2010 美国斯克里普斯研究所博士后 2010-2014 美国斯克里普斯研究所助理教授，独立课题组长 2014-2016 美国斯克里普斯研究所副教授，研究员

研究领域

生物复杂性机制，癌症免疫新机制，新药物与研发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Schimmel P, Guo M. A tipping point for mistranslation and disease. Nature Structure Molecular Biology, 2009 16: 348-349 Guo M, Chong YE, Beebe K, Shapiro R, Yang XL, Schimmel P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA. Science, 2009 325: 744-777 Guo RT, Chong YE, Guo M, Yang XL. Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis. J. Biol. Chem., 2009 284: 28968-28976 Guo M, Chong YE, Shapiro R, Beebe K, Yang XL, Schimmel P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 2009 462: 808-812 Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat. Struct. Mol. Biol., 2010 17: 57-61 Guo M, Schimmel P, Yang XL. Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett., 2010 584: 434-442 Guo M, Shapiro R, Schimmel P, Yang XL. Introduction of a leucine half-zipper engenders multiple high quality crystals of a recalcitrant tRNA synthetase. Acta Cryst. D, 2010 66: 243-250 Guo M, Yang XL, Schimmel P. New functions of tRNA synthetases beyond translation. Nature Reviews Molecular Cell Biology, 2010 11: 668-674 Guo M, Shapiro R, Morris GM, Yang XL, Schimmel P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase. Journal of Physical Chemistry, 2010 114: 16273-16279 Fang P, Zhang HM, Shapiro R, Marshall AG, Schimmel P, Yang XL*, Guo M*. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc. Natl. Acad. Sci. USA, 2011 108: 8239-8244 *Co-corresponding author Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem, 2011 12: 2140-2142 He W, Zhang HM, Chong YE, Guo M, Marshall AG, Yang XL. Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc. Natl. Acad. Sci. USA, 2011 108: 12307-12312 Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations. Biochemistry, 2011 50: 9928-9935. Guo M, Schimmel P. Structural analyses clarify the complex control of mistranslation by tRNA synthetases. Curr. Opin. Struct. Biology, 2012 22: 119-126. Xu XL, Shi Y, Zhang HM, Marshall AG, Guo M, Kishi S, Yang XL. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development. Nature Communications, 2012 3: 681 Sajish M, Zhou Q, Kishi S, Valdez DJ, Kapoor M, Guo M, Kim S, Yang XL. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nature Chemical Biology, 2012 8: 547-554 Park MC, Kang T, Jin D, Han JM, Kim SB, Park YC, Cho K, Park YW, Guo M, He W, Yang XL, Paul Schimmel P, Kim S. Secreted Human Gly-tRNA Synthetase Implicated in Defense Against ERK-Activated Tumorigenesis. Proc. Natl. Acad. Sci. USA, 2012 109: E640-647 Guo M, Schimmel P. Homeostatic mechanism by alternative forms of tRNA synthetases. Trends in Biochemistry Sciences, 2012 37: 401-403 Wang J, Fang P, Schimmel P, Guo M. Side Chain Independent Recognition of Aminoacyl-Adenylates by the Hint1 Transcription Suppressor. Journal of Physical Chemistry, 2012 116: 6798-6805 Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M. Structural switch of lysyl-tRNA synthetase function between translation and transcription. Mol. Cell, 2013 49: 30-42