Sweedler, Jonathan V. - University of Illinois at Urbana-Champaign

个人简介

Professor Sweedler received his B.S. degree in Chemistry from the University of California at Davis in 1983 and his Ph.D. from the University of Arizona in 1989. Thereafter, he was an NSF Postdoctoral Fellow with Dr. Richard Zare and Dr. Richard Scheller at Stanford University, and joined the faculty at Illinois in 1991. He is associated with the Beckman Institute, Biotechnology Center, Neuroscience Program and Bioengineering Program.

研究领域

His research interests are in bioanalytical chemistry, and focus on developing new methods for assaying nanoliter volume samples, and applying these methods to study the distribution and dynamic release of neurotransmittors and neuropeptides from individual neurons. Specifically, he is investigating the roles that peptide hormones, neurotransmitters and neuromodulatory agents play in behavior, learning and memory.

近期论文

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Correlated Imaging with C60-SIMS and Confocal Raman Microscopy: Visualization of Cell-Scale Molecular Distributions in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, S.J. Dunham, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem., 2014, in press. Analysis of Endogenous Nucleotides by Single Cell Capillary Electrophoresis-Mass Spectrometry, J-X. Liu, J.T. Aerts, S.S. Rubakhin, X-X. Zhang, J.V. Sweedler, Analyst, 2014, in press. MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, J.T. Aerts, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 86, 2014, 9139–9145. Biomolecular Imaging with a C60-SIMS/MALDI Dual Ion Source Hybrid Mass Spectrometer: Instrumentation, Matrix Enhancement, and Single Cell Analysis, E.J. Lanni, S.J.B. Dunham, P. Nemes, S.S. Rubakhin, J.V. Sweedler, J. Amer. Soc. Mass Spectrom., 2014, in press. Integration of Untargeted Metabolomics with Transcriptomics Reveals Active Metabolic Pathways, K. Cho, B.S. Evans, B.M. Wood, R. Kumar, T.J. Erb, B.P. Warlick, J.A. Gerlt, J.V. Sweedler, Metabolomics, 2014, in press. Spatial Organization of Pseudomonas Aeruginosa Biofilms Probed by Combined Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Confocal Raman Microscopy, R.N. Masyuko, E.J. Lanni, C.M. Driscoll, J.D. Shrout, J.V. Sweedler, P.W. Bohn, Analyst, 2014, in press. The Ctenophore Genome and the Evolutionary Origins of Neural Systems, L.L. Moroz, K.M. Kocot, M.R. Citarella, S. Dosung, T.P. Norekian, I.S. Povolotskaya, A.P. Grigorenko, C. Dailey, E. Berezikov, K.M. Buckley, A. Ptitsyn, D. Reshetov, K. Mukherjee, T.P. Moroz, Y. Bobkova, F. Yu, V.V. Kapitonov, J. Jurka, Y.V. Bobkov, J.J. Swore, D.O. Girardo, A. Fodor, F. Gusev, R. Sanford, R. Bruders, E. Kittler, C.E. Mills, J.P. Rast, R. Derelle, V.V. Solovyev, F.A. Kondrashov, B.J. Swalla, J.V. Sweedler, E.I. Rogaev, K.M. Halanych, A.B. Kohn, Nature 510, 2014,109–114. Fibrinogen-α Chain-derived Peptide is Upregulated in Hippocampus of Rats Exposed to Acute Morphine Injection and Spontaneous Alternation Testing, A.E. Maki, K.A. Morris, K. Catherman, X. Chen, N.G. Hatcher, P.E. Gold, J.V. Sweedler, Pharma. Res. Perspect. 2, 2014, e00037. d-Alanine in the Islets of Langerhans of Rat Pancreas, N. Ota, S.S. Rubakhin, J.V. Sweedler, Biochem. Biophys Res. Commun. 447, 2014, 328–333. Application of Capillary Electrophoresis for the Early Diagnosis of Cancer, Z. Yang and J.V. Sweedler, Anal. Bioanal. Chem.406, 2014, 4013–4031. Patch Clamp Electrophysiology and Capillary Electrophoresis–Mass Spectrometry Metabolomics for Single Cell Characterization, J.T. Aerts, K.R. Louis, S.R. Crandall, G. Govindaiah, C.L. Cox, J.V. Sweedler, Anal. Chem. 86, 2014, 3203–3208. Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine, R. Kumar, S. Zhao, M.W. Vetting, B.M. Wood, A. Sakai, K. Cho, J. Solbiati, S.C. Almo, J.V. Sweedler, M.P. Jacobson, J.A. Gerlt, J.E. Cronan, MBio 5, 2014, e00933-00913. Comparing Label-free Quantitative Peptidomics Approaches to Characterize Diurnal Variation of Peptides in the Rat Suprachiasmatic Nucleus, B.R. Southey, J.E. Lee, L. Zamdborg, N. Atkins, Jr., J.W. Mitchell, M. Li, M.U. Gillette, N.L. Kelleher, J.V. Sweedler, Anal. Chem., 86, 2014, 443–452. Small-Volume Analysis of Cell-Cell Signaling Molecules in the Brain, E.V. Romanova, J.T. Aerts, C.A. Croushore, J.V. Sweedler, Neuropsychopharmacology 39, 2014, 50–64. Characterization of GdFFD, a D-Amino Acid-Containing Neuropeptide, that Functions as an Extrinsic Modulator of the Aplysia Feeding Circuit, L. Bai, I. Livnat, E.V. Romanova, V. Alexeeva, P.M. Yau, F.S. Vilim, K.R. Weiss, J.Jing, J.V. Sweedler, J. Biol. Chem. 288, 2013, 32837-32851. Discovery of New Enzymes and Metabolic Pathways using Structure and Genome Context, S. Zhao, R. Kumar, A. Sakai, M.W. Vetting, B.M. Wood, S. Brown, J.B. Bonanno, B.S. Hillerich, R.D. Seidel, P.C. Babbitt, S.C. Almo, J.V. Sweedler, J.A. Gerlt, J.E. Cronan, M.P. Jacobson, Nature 502, 2013, 698–702. Stimulation and Release from Neurons via a Dual Capillary Collection Device Interfaced to Mass Spectrometry, Y. Fan, C.Y Lee, S.S. Rubakhin, J.V. Sweedler, Analyst 138, 6337-6346. Signals from the Brainstem Sleep/Wake Centers Regulate Behavioral Timing via the CIrcadian Clock, S.M. Abbott, J.M. Arnold, Q. Chang, H. Miao, N. Ota, C. Cecala, P.E. Gold, J.V. Sweedler, M.U. Gillette, PLoS One 8, 2013, e70481. Quantitation of Endogenous Peptides by Mass Spectrometry Based Methods, E.V. Romanova, S.E. Dowd, J.V. Sweedler, Curr. Opin. Chem. Biol. 17, 2013, 801–808. Laminar Stream of Detergents for Subcellular Neurite Damage in a Microfluidic Device: A Simple Tool for the Study of Neuroregeneration, C.Y. Lee, E.V. Romanova, J.V. Sweedler, J. Neural Eng. 10, 2013, 036020.