苗龙 - 中国科学院生物物理研究所 -

个人简介

1999年博士毕业于中国农业大学 1999-2000年加州大学（戴维斯）博士后 2001-2006年佛罗里达州立大学生物系博士后 2007年至今中国科学院生物物理研究所研究员中国细胞生物学会会员(2007-至今) 中国生物物理学会会员(2007-至今) 美国细胞生物学会 (ASCB) 会员(2000-至今) 美国科学促进会 (AAAS）会员(2004-至今)

研究领域

1、精子主要蛋白MSP发挥精子运动骨架及胞外信号分子双重功能的分子机理研究 2、MSP同源蛋白质在—肌萎缩性侧索硬化症中发挥功能的可能机理研究

近期论文

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1.Zhu H, Chen L, Yang Y, Zhu Z, Zhang X, Li W, Miao L, Zhang Y, Ou G. (2016) The glial actin cytoskeleton regulates neuronal ciliogenesis. Cell Res [Epub ahead of print]. doi: 10.1038/cr.2016.131 2.Li Y, Chen B, Zou Z, Wang X, Wu Y, Zhao D, Sun Y, Liu Y, Chen L, Miao L, Yang C and Wang X. (2016) Lysosomal integral membrane protein SCAV-3 maintains lysosome integrity and normal adult lifespan in C. elegans. JCB 215(2):167-185. 3.Li Y, Xu M, Ding X, Yan C, Song Z, Chen L, Huang X, Wang X, Jian Y, Tang G, Tang C, Di Y, Mu S, Liu X, Liu K, Li T, Wang Y, Miao L, Guo W, Hao X, and Yang C. (2016) Protein kinase C controls lysosome biogenesis independently of mTORC1. Nat Cell Biol 18:1065-1077. 4.Li R, Ren X, Bi Y, Ho VW, Hsieh CL, Young A, Zhang Z, Lin T, Zhao Y, Miao L, Sarkies P, Zhao Z. (2016) Specific down-regulation of spermatogenesis genes targeted by 22G RNAs in hybrid sterile males associated with an X-Chromosome introgression. Genome Res. 9:1219-1932. 5.Wang Y, Zhang Y, Chen L, Liang Q, Yin XM, Miao L, Kang BH, Xue D. (2016) Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans. Nat Commun. 7:12569. 6.Miao L and L'Hernault SW. (2014) Role of posttranslational modifications in C. elegans and Ascaris spermatogenesis and sperm function. In: Posttranslational Protein Modifications in the Reproductive System, edited by Peter Sutovsky. Springer Science+Business Media, LLC. 7.Ma X, Zhu Y, Li C, Huang P, Cao Z, Liu Z, Zhao Y, Xue P, Chen S, Yang F, Miao L. (2014) Characterization of Caenorhabditis elegans sperm mRNAome. BMC Genomics 15:168. 8.Liu Z, Wang B, He R, Zhao Y, Miao L. (2014) Calcium signaling and the MAPK cascade are required for sperm activation in Caenorhabditis elegans. Biochim Biophys Acta. 1843:299-308. 9.Shang Y, Chen L, Liu Z, Ma X, Miao L. (2013) Cytosolic Ca2+ as a multifunctional modulator is required for spermiogenesis and motility acquisition in Ascaris suum. Protein & Cell 4:456-466. 10. Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y, and Yang C. (2013). Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans. PLoS Genetics 9(5), e1003517. 11. Liu Z, Chen L, Shang Y, Huang P, Miao L. (2013) The micronutrient element zinc modulates sperm activation through the SPE-8 pathway in Caenorhabditis elegans. Development 140: 2103-2107. 12. Huang P, Ma X, Zhao Y, Miao L. (2013) The C. elegans homolog of RBBP6 (RBPL-1) regulates fertility through controlling cell proliferation in the germline and nutrient synthesis in the intestine. PLoS ONE 8(3): e58736. 13. Ma X, Zhao Y, Sun W, Shimabukuro K, Miao L. (2012) Transformation: how do nematode sperm become activated and crawl? Protein & Cell 10:755-761. 14. Dou J, Chen L, Hu Y, Miao L. (2012) Cholesterol and the biosynthesis of glycosphingolipids are required for sperm activation in Caenorhabditis elegans. Biochim Biophys Acta 1821:934-942. 15. Zhao Y, Sun W, Zhang P, Chi H, Zhang M, Song C, Ma X, Shang Y, Wang B, Hu Y, Hao Z, Hühmer A, Meng, F, L'Hernault S, He S, Dong M, Miao L. (2012) Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin). PNAS 109: 1542–1547. 16. Ma X, Zhu Y, Li C, Shang Y, Meng F, Chen S, Miao L. (2011) Comparative transcriptome sequencing of Germline and Somatic Tissues of the Ascaris suum Gonad. BMC Genomics 12:481. 17. Su S, Liu Z, Chen C, Zhang Y, Wang X, Zhu L, Miao L, Wang X, Yuan M. (2010) Cucumber Mosaic Virus Movement Protein Severs Actin Filaments to Increase the Plasmodesmal Size Exclusion Limit in Tobacco. The Plant Cell 22:1161-1173. 18. Chen D, Xiao D, Zhang K, Wang B, Gao Z, Jian Y, Qi X, Sun J, Miao L, Yang C. (2010) Retromer Sorting Complex Regulates Apoptotic Cell Clearance by Phagocytic Receptor Recycling. Science 327: 1261-1264. 19. Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, Zhao Y, Li Z, Song B, Han J, Miao L, Zhang H. (2009) SEPA-1 Mediates the Specific Recognition and Degradation of P Granule Components by Autophagy in C. elegans. Cell 136: 308–321. 20. Miao L, Vanderlinde O, Liu J, Grant RP., Wouterse A, Philipse A, Stewart M, Roberts TM. (2008) The role of filament packing dynamics in powering amoeboid cell motility. PNAS 105: 5390-5395