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招生专业 071009-细胞生物学 100102-免疫学 招生方向 慢性炎症恶性转化的分子机制;抗肿瘤免疫学机制和免疫治疗新策略 肿瘤免疫微环境 T细胞免疫的调控机制; 教育背景 2004-03--2005-02 美国Johns Hopkins University School of Medicine 助理研究员 1998-10--2004-02 美国Mayo Clinic Medical School 博士后/助理研究员 1995-09--1998-06 中国医学科学院协和医科大学 博士 工作简历 2005-03~现在, 中国科学院生物物理研究所, 研究员 发表著作 ( 1 ) 抗病毒天然免疫与适应性免疫的关系. 《抗病毒天然免疫》, Innate Immunity against virus, 科学出版社, 2009-04, 第 2 作者 科研项目 ( 1 ) 慢性肝炎恶性转化的分子机制研究, 主持, 国家级, 2011-01--2013-12 ( 2 ) 防治乙型肝炎新技术、新方法的研究, 参与, 国家级, 2012-01--2015-12 ( 3 ) 慢性乙型病毒肝炎临床转归预警预测的研究, 参与, 国家级, 2012-01--2015-12 ( 4 ) 肿瘤细胞与免疫细胞膜蛋白分子间的相互作用, 主持, 国家级, 2012-01--2016-12 ( 5 ) 细胞逐步适应新环境的多基因作用机制, 主持, 国家级, 2013-01--2016-12 参与会议 (1)The roles of co-signaling pathways in pathogenesis of chronic hepatitis B 第8届海峡两岸细胞生物学学术研讨会 王盛典 2011-05-13 (2)Immunological mechanisms of tumor clinical therapy 2010年北京免疫学会年会 王盛典 2011-01-09 (3)机体免疫反应在抗her2抗体治疗中的作用 中国免疫学会第七届学术大会 王盛典 2010-10-22

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(1) Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype, Journal of immunology, 2015, 通讯作者 (2) PD-1+, CD8+ T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients, British Journal of Cancer, 2014, 通讯作者 (3) Hyper-IL-15 suppresses metastatic and autochthonous liver cancer by promoting tumour-specific CD8+ T cell responses, Journal of Hepatology, 2014, 通讯作者 (4) Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection., Journal of Viral Hepatitis, 2012, 通讯作者 (5) A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models., Journal of Immunology, 2012, 第 2 作者 (6) CD8+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model, Chinese Science Bulletin, 2012, 通讯作者 (7) Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal athways, Current Topics in Microbiology and Immunology, 2011, 第 1 作者 (8) The development and functions of CD4+ T cells expressing a transgenic TCR specific for an MHC I-restricted tumor antigenic epitope., Cellular and Molecular Immunology, 2011, 通讯作者 (9) B7-H2 is a costimulatory ligand for CD28 in human. Immunity, Immunity, 2011, 通讯作者 (10) Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cells-mediated liver injury in mice, PLoS One, 2011, 通讯作者 (11) he Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity., Cancer Cell, 2010, 通讯作者 (12) CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice., Journal of Immunology, 2010, 通讯作者 (13) Accumulation of Foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients., Clinical Cancer Research, 2010, 通讯作者 (14) Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 gene., Journal of Clinical Immunology, 2010, 通讯作者 (15) Structural immunology of costimualtory and coinhibitory molecules, Science China Life Sciences, 2010, 第 1 作者 (16) 从动物模型看乙型肝炎致病机制的研究进展., 生命科学, 2010, 通讯作者 (17) CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection, Hepatology, 2010, 通讯作者

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