刘玲 - 中国科学院微生物研究所 -

个人简介

工作经历 2018/3 - 至今，中国科学院微生物研究所，青年课题组长，项目研究员 2016/11 - 2018.12，加州大学洛杉矶分校，访问学者 2011/7 - 至2018/2，中国科学院微生物研究所，副研究员 2009/7 - 2011/6，中国科学院微生物研究所，助理研究员教育经历 2005/9 - 2009/6，中国科学院微生物研究所，生物化学与分子生物学，博士 2002/9 - 2005/6，中国科学院成都生物研究所，药物化学，硕士

研究领域

长期从事真菌天然药物的发现及生物合成途径研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Pan Y. #; Liu, L. #; Guan, F.; Li, E.; Lin, J.; Li, J.; Che, Y. *; Liu, G. * Characterization of a prenyltransferase for iso-A82775C biosynthesis and generation of new congeners of chloropestolides. ACS Chem. Biol. 2018, 13, 703-711. 2. Yan, S. #; Liu, L. #; Ren, F.; Gao, Q.; Xu, S.; Hou, B.; Wang, Y.; Jiang, X.; Che, Y.* Sunitinib induces genomic instability of renalcarcinoma cells through affecting the interaction of LC3-II and PARP-1. Cell Death and Disease. 2017, 8(8):e2988 3. Lin, J.; Wang, R.; Xu, G.; Ding, Z.; Zhu, X.; Li, E.; Liu, L. * Two new polyketides from the ascomycete fungus Leptosphaeria sp. J. Antibiot. 2017, 70: 743–746. 4. Lin, J.; Niu, S.; Ding, Z.; Wang, R.; Dai, Q.; Wei, W.; Luo, R.; Liu, L.* Isolation and characterization of Aphidicolin derivatives from Tolypocladium inflatum. Molecules, 2017, 22: 1168. 5. Liu, L.; Han, Y.; Xiao, J.; Li, L.; Guo, L.; Jiang, X.; Che, Y.* Chlorotheolides A and B, spiroketals generated via Diels−Alder reactions in the endophytic fungus Pestalotiopsis theae. J. Nat. Prod. 2016, 79: 2616–2623. 6. Lin, J.; Wang, R.; Xu, G.; Ding, Z.; Zhu, X.; Liu, X.; Zou, J.; Chen, G.; Li, L.; Liu, L.* New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp. RSC Adv. 2016, 6, 112527–112533. 7. Wang, B.; Zhang Z.; Guo, L.; Liu, L.* New cytotoxic meroterpenoids from the plant endophytic fungus Pestalotiopsis fici. Helv. Chim. Acta. 2016, 99, 151–156. 8. Liu, L.#; Chen, X.#; Li, D.; Zhang, Y.; Li, L.; Guo, L.; Cao, Y.*; Che, Y.* Bisabolane sesquiterpenoids from the plant endophytic fungus Paraconiothyrium brasiliense. J. Nat. Prod. 2015, 78 (4): 746–753. 9. Zhang, J. #; Liu, L. #; Wang, B.; Zhang, Y.; Wang, L.; Liu, X.; Che, Y.* Phomanolides A and B from the fungus Phoma sp.: Meroterpenoids derived from a putative tropolonic sesquiterpene via hetero Diels–Alder reactions. J. Nat. Prod. 2015, 78, 3058–3066. 10. Liu, L.; Zhao, C.; Li, L.; Guo, L.; Che, Y. * Pestalotriols A and B, new spiro[2.5]octane derivatives from the endophytic fungus Pestalotiopsis fici. RSC Adv. 2015, 5, 78708–78711. 11. Guo, Z.; Ren, F.; Che, Y; Liu, G.; Liu, L.* New bergamotane sesquiterpenoids from the plant endophytic fungus Paraconiothyrium brasiliense. Molecules, 2015, 20: 14611–14620. 12. Xu, X.#; Liu, L.#; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.* Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici. ChemBioChem. 2014, 15, 284–292. 13. Liu, L.; Li,Y.; Li, L.; Cao,Y.*; Guo, L.; Liu, G.; Che,Y.* Spiroketals of Pestalotiopsis fici provide Evidence for a Biosynthetic Hypothesis Involving Diversified Diels-Alder Reaction Cascades. J. Org. Chem. 2013, 78, 2992–3000. 14. Liu, S.; Guo, L.; Che, Y.*; Liu, L.* Pestaloficiols Q–S from the plant endophytic fungus Pestalotiopsis fici. Fitoterapia, 2013, 85, 114–118. 15. Liu, S.; Liu, X.; Guo, L.; Che, Y.*; Liu, L.* 2H-pyran-2-one and 2H-furan-2-one derivatives from the plant endophytic fungus Pestalotiopsis fici. Chem. Biodivers. 2013, 10, 2007–2013. 16. Liu, L.#; Bruhn, T.#; Guo, L.; Götz, D. C. G.; Brun, B.; Stich, A.; Che, Y.*; Bringmann, G.* Chloropupukeanolides C–E, cytotoxic pupukeanane chlorides with a spiroketal skeleton from Pestalotiopsis fici. Chem. Eur. J. 2011, 17, 2604–2613. 17. Liu, L.; Niu, S.; Lu, X.; Chen, X.; Zhang, H.; Guo, L.; Che, Y. * Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification. Chem. Commun. 2010, 46(3), 460–462. 18. Liu, L.; Gao, H.; Chen, X.; Cai, X.; Yang, L.; Guo, L.; Yao, X.; and Che, Y.*. Brasilamides A–D, sesquiterpenoids from the plant endophytic fungus Paraconiothyrium brasiliense. Eur. J. Org. Chem. 2010, 2010(17), 3302–3306. 19. Liu, L.; Li, Y.; Liu, S.; Zheng, Z.; Chen, X.; Guo, L.; Che, Y.* Chloropestolide A, an antitumor metabolite with an unprecedented spiroketal skeleton from Pestalotiopsis fici. Org. Lett. 2009, 11(13), 2836–2839. 20. Liu, L.; Liu, S.; Chen, X.; Guo, L.; Che, Y.* Pestalofones A–E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Bioorg. Med. Chem. 2009, 17, 606–613.