个人简介
1990.09-1994.07兰州大学, 生物化学专业, 获理学学士学位
1998.09-2003.07中国科学院遗传与发育生物学研究所，遗传学专业，获理学博士学位
1994.08-1998.08 陕西航天制药厂，助理工程师
2003.08-2008.06 美国福克斯肿瘤研究中心，博士后
2008.07-2010.02美国福克斯肿瘤研究中心，Research Associate
2010.03-2012.06美国福克斯肿瘤研究中心, Staff Scientist
2012.06-至今 中国科学院微生物研究所 研究员、博士生导师
近期论文
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1. Acquired" NKG2D Ligand Stimulates NK Cell-mediated Tumor Immunosurveillance. Wang D, Gu X, Liu X, Liu X, Wang B, Lao F, Fang M#. J Immunother. 2019; 42(6):189-196.
2. Influenza virus matrix protein M1 interacts with SLD5 to block host cell cycle. Zhu L, Zhao W, Lu J, Li S, Zhou K, Jiang W, Duan X, Fu L, Yu B, Cai KQ, Gao GF, Liu W, Fang M#. Cell Microbiol. 2019 :e13038. doi: 10.1111/cmi.13038.
3. Migratory Dendritic Cells, Group 1 Innate Lymphoid Cells, and Inflammatory Monocytes Collaborate to Recruit NK Cells to the Virus-Infected Lymph Node. Wong E, Xu RH, Rubio D, Lev A, Stotesbury C, Fang M, Sigal LJ. Cell Rep. 2018; 24(1):142-154.
4. GALNT3 inhibits NF-κB signaling during Influenza A virus infection. Wang B, Zhang Y, Jiang W, Zhu L, Li K, Zhou K, Dai D, Chang S, Fang M#. Biochem Biophys Res Commun. 2018;503(4):2872-2877.
5. The virulence of L. pneumophila is positively correlated with its ability to stimulate NF-κB activation. Wang H, Lu J, Li K, Ren H, Shi Y, Qin T#, Duan X#, Fang M#. Future Microbiol. 2018;13:1247-1259.
6. Development and Characterization of Stable Reporter Cells for Fast and Sensitive Detection of Pyrogen. Li L, Xu H, Jiang W, Li J, Liu W, Wang T#, Fang M#. Anal Biochem. 2018;557:69-76.
7. NK cells inhibit anti-M.bovis BCG T cell responses and aggravate pulmonary inflammation in a direct lung infection mouse model. Wang D, Gu X, Liu X, Wei S, Wang B, Fang M#. Cell Microbiol. 2018; 20(7):e12833.
8. Endogenous Cellular microRNAs Mediate Antiviral Defense against Influenza A Virus. Peng S, Wang J, Wei S, Li C, Zhou K, Hu J, Ye X, Yan J, Liu W, Gao GF, Fang M#, Meng S#. Mol Ther-Nucl Acids. 2018; 10:361-375.
9. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology. Lu J, Duan X, Zhao W, Wang J, Wang H, Zhou K, Fang M#. Aging Dis. 2018; 9(3):358-373
10. Natural killer cells are activated and play a protective role against ZIKA virus infection in mice. Duan X, Li S, Wong G, Wang D, Wang H, Lu J, Bi Y, Lu X, Shi Y, Yan J, Fang M#, Gao GF#. Sci Bull, 2017; 62:982-984.
11. Bidirectional factors impact the migration of NK cells to draining lymph node in aged mice during influenza virus infection. Duan X, Lu J, Wang H, Liu X, Wang J, Zhou K, Jiang W, Wang Y, Fang M#. Exp Gerontol. 2017; 96:127-137.
12. Changes of peripheral lymphocyte subsets and cytokine environment during ageing and deteriorating gastrointestinal tract health status. Wang J, Yang G, Wang D, Liu K, Ma Y, Liu H, Wu J#, Fang M#. Oncotarget. 2017; 8(37): 60764-60777.
13. Suppression of Rac1 Signaling by Influenza A Virus NS1 Facilitates Viral Replication. Jiang W, Sheng C, Gu X, Liu D, Yao C, Gao S, Chen S, Huang Y, Huang W#, Fang M#. Sci Rep. 2016; 6: 35041.
14. NK Cell Responses to Influenza Virus are Affected by Host Genetics and Infecting Viral Doses. Zhou K, Wang J, Fang M#. Austin Immunol. 2016; 1(1):1-2.
15. Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection. Zhou K, Wang J, Li A, Zhao W, Wang D, Zhang W, Yan J, Gao GF, Liu W, Fang M#. J Immunol. 2016; 196(4):1842-54.
16. Protective CD8+ T cell memory without help. Fang M#, Sigal LJ#. Oncotarget. 2015; 6(30):28529-28530.
17. Natural Killer Cells are involved in Thymic Atrophy induced by InfluenzaA Virus Infection. Duan X, Lu J, Zhou K, Wang J, Wu J, Gao GF, Fang M#. J Gen Virol. 2015, 96:3223–3235
18. Synthesis and Biological Activities of 5-Thio-α-GalCers. Bi J, Wang J, Zhou K, Wang Y, Fang M#, Du Y#. ACS Med Chem Lett, 2015, 6(4): 476–480.
19. The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment. Nair S, Fang M, Sigal LJ. Aging Cell. 2015; 14(2):180-90.
20. CD4+ T Cell Help Is Dispensable for Protective CD8+ T Cell Memory against Mousepox Virus following Vaccinia Virus Immunization. Fang M#, Remakus S, Roscoe F, Ma X, Sigal LJ#. J Virol. 2015; 89(1):776-83.
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