张福萍 - 中国科学院微生物研究所 -

个人简介

1. 2011.03-至今中国科学院微生物研究所，研究员，研究组长； 2. 2006-2011年 National institute of Health, IRTA fellow； 3. 2002-2006年 Vanderbilt University Medical Center, research fellow； 4. 1998-2001年中国预防医学科学院病毒所，博士研究生； 5. 1989-1998年新疆农业大学，讲师。

研究领域

1. T细胞分化为不同辅助性T细胞的转录调控机制； 2. 病毒感染与免疫； 3. 肠道菌群与肠炎发生机制研究

近期论文

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1. Han X, Huang H, Gao P, Zhang Q, Liu X, Jia B, Warren Strober, Hou B, Zhou X, Gao GF, Zhang F*. E-protein regulatory network links TCR signaling to effector Treg cell differentiation, Proc Natl Acad Sci U S A. 2019, 116(10): 4471-4480. 2. Han X, Liu H, Huang H, Liu X, Jia B, Gao GF, Zhang F*. ID2 and ID3 are indispensable for Th1 cell differentiation during influenza virus infection in mice. Eur J Immunol. 2019, 49(3):476-489. 3. Huang H, Li S, Zhang Y, Han X, Jia B, Liu H, Liu D, Tan S, Wang Q, Bi Y, Liu WJ, Hou B, Gao GF*, Zhang F*. CD8+ T Cell Immune Response in Immunocompetent Mice during Zika Virus Infection. J Virol. 2017, 91(22). 4. Gao P, Liu H, Huang H, Zhang Q, Strober W, Zhang F*. The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice. J Immunol. 2017, 198(6): 2457-2467. 5. Gao P, Han X, Zhang Q, Yang Z, Fuss IJ, Myers TG, Gardina PJ, Zhang F*, Strober W*(2014). Dynamic changes in E-protein activity regulate T reg cell development. J Exp Med. 2014; 211 (13):2651-68. * Correspondence Author 6. Zhang, F*. , Fuss, I., Yang, Z., and Strober, W* (2014) Transcription of RORgt in Developing Th17 cells is Regulated by E-Protiens . Mucosal Immunology. 2014, 7(3):521-32. * Correspondence Author 7. Strober W, Zhang F, Kitani A, Fuss I, Fichtner-Feigl S. (2010) Proinflammatory cytokines underlying the inflammation of Crohn's disease. Curr Opin Gastroenterol. Jul; 26 (4):310-7. 8. Meng, G., Zhang, F., Fuss, I., Kitani, A., and Strober, W. (2009) A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses. Immunity. 30:860-874. 9. Zhang, F., Meng, G. and Strobe, W. (2008) Interactions among transcription factors Runx1, RORt and Foxp3 regulate differentiation of interleukin17-producing T cells. Nature Immunology. 9 :1297-1306. 10. Zhang, F. and Boothby, M. (2006) Th1-specific Brg1 recruitment and remodeling of nucleosomes positioned at IFN-γ promoter is STAT4-dependent. J Exp Med. 203:1493-1505. 11. Corn, R.A., Aronica M.A., Zhang, F. et al. (2003) T cell-intrinsic requirement for NF-kappa B induction in post differentiation IFN-gamma production and clonal expansion in a Th1 response. Journal of Immunology. 171(4): 1816-1824. 12. Zhang, F., Zhang, J., Zhou, W. et al. (2002) Expression of PrPc as His-fusion form in a baculovirus system and conversion of expressed PrP-sen to PrP-res in cell-free system. Virus Research. 87:145-153. 13. Zhang, F., Dong, X., Zhou, W. et al. (2002) Cloning and expression of S100 protein and establishment method to test S100 protein. Chinese Journal of Experiment medicine. (1) 48-55. 14. Zhang, F., Dong, X., Sun, X. et al. (2000) Preparation and primary application of 14-3-3 specific polyclonal antibody. Chinese Journal of Neurology. 33(5) :331-335. 15. Zhang, F., Dong, X., Zhao, X. et al. (1999) cDNA cloning and expression in prokaryotic cells of neuron protein 14-3-3beta. Chinese Journal of Neurology. 32(4): 230-233.