米凯霞 - 中国科学院微生物研究所 -

个人简介

1999-2003年中国科学院微生物研究所博士 2003-2004年美国UT Health Science Center, San Antonio博士后 2004-2009年美国Albert Einstein College of Medicine研究助理 2009-2017年中国科学院病原微生物与免疫学重点实验室青年课题组组长 2017-至今中国科学院病原微生物与免疫学重点实验室课题组组长

研究领域

结核分枝杆菌等重要病原微生物耐药机制

近期论文

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Li X, Zhang Y, Zhou X, Hu X, Zhou Y, Liu D, Maxwell A, Mi K. The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress. Mol Microbiol. 2019, 111(6):1529-1543. Zhang Q, Liu H, Liu X, Jiang D, Zhang B, Tian H, Yang C, Guddat LW, Yang H, Mi K, Rao Z. Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein Cell. 2018, 9:971-975. Li T, Zhao Q, Yang X, Chen C, Yang K, Wu C, Zhang T, Duan Y, Xue X, Mi K, Ji X, Wang Z, Yang H. Structural insight into the Zika virus capsid encapsulating the viral genome. Cell Res. 2018, 28(4):497-499. Zhang Y, Hu X, Li X, Deng H, Mi K. Mechanisms of MSMEG_3312-mediated collective antibiotic tolerance to erythromycin in mycobacteria revealed by quantitative proteomic analysis. Acta Microbiologica Sinica, 2018, 58(9):1-18. Glass LN, Swapna G, Chavadi SS, Tufariello JM, Mi K, Drumm JE, Lam TT, Zhu G, Zhan C, Vilcheze C, et al. Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth. PLoS Pathog. 2017, 13:e1006515. Jia Q, Hu X, Shi D, Zhang Y, Sun M, Wang J, Mi K, Zhu G. Universal stress protein Rv2624c alters abundance of arginine and enhances intracellular survival by ATP binding in mycobacteria. Sci Rep. 2016, 6:35462. Hu X, Li X, Huang L, Chan J, Chen Y, Deng H, Mi K. Quantitative proteomics reveals novel insights into isoniazid susceptibility in mycobacteria mediated by a universal stress protein. J Proteome Res. 2015, 14:1445-1454. Zhang Y, Mandava CS, Cao W, Li X, Zhang D, Li N, Zhang Y, Zhang X, Qin Y, Mi K, Lei J, Sanyal S, Gao N. HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions. Nat Struct Mol Biol. 2015, 22(11):906-13. Gu L, Chen Y, Wang Q, Li X, Mi K, Deng H. Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis. J Proteome Res. 2015, 14(11):4441-9. Li X, Wu J, Han J, Hu Y, Mi K. Distinct Responses of Mycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide. PLoS One. 2015, 10(7):e0134595. Li X, Tao J, Hu X, Chan J, Xiao J, Mi K. A bacterial hemerythrin-like protein MsmHr inhibits the SigF-dependent hydrogen peroxide response in mycobacteria. Front Microbiol. 2014, 5:800. Li X, Tao J, Han J, Hu X, Chen Y, Deng H, Zhang G, Hu X, Mi K. The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress. Protein Cell. 2014, 5:182-185. Li X, Liu F, Hu Y, Mi K. Draft Genome Sequence of mc251, a Highly Hydrogen Peroxide-Resistant Mycobacterium smegmatis Mutant Strain. Genome Announc. 2014, 2. Tao J, Han J, Wu H, Hu X, Deng J, Fleming J, Maxwell A, Bi L, Mi K. Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance. Nucleic Acids Res. 2013, 41:2370-2381.