个人简介
教育经历
1983，南开大学，微生物学专业，学士
2005，江南大学，生物工程专业，博士
工作经历
1983-1988年 中国科学院微生物研究所，研究实习员
1988-1995年 中国科学院微生物研究所，助理研究员
1995-1999年 中国科学院微生物研究所，副研究员
1999-至今 中国科学院微生物研究所，研究员
2004-2008年 中国科学院微生物研究所，所长助理
2007-2008年 中国科学院天津工业生物技术研究与发展中心（筹），筹备工作组组长
2008-2012年 中国科学院天津工业生物技术研究所（筹），筹备工作组副组长
2012-至今 中国科学院天津工业生物技术研究所，所长
2008-至今 工业酶国家工程实验室，主任
研究领域
极端环境微生物的资源发掘、生理机制认识和生物技术利用
近期论文
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1. Bo Liu, Shuman Xiang, Guang Zhao, Bojun Wang, Yanhe Ma *, Weifeng Liu *, Yong Tao. 2019. Efficient production of 3-hydroxypropionate from fatty acids feedstock in Escherichia coli. Metabolic Engineering. Jan; 51:121-130.
2. Cheng Zhou, Hongliang Qin, Xiujuan Chen, Yan Zhang, Yanfen Xue, Yanhe Ma *. 2018. A novel alkaline protease from alkaliphilic Idiomarina sp. C9-1 with potential application for eco-friendly enzymatic dehairing in the leather industry. Scientific Reports. Nov 7;8(1):16467.
3. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2018. Characterization and high-efficiency secreted expression in Bacillus subtilis of a thermo-alkaline β-mannanase from an alkaliphilic Bacillus clausii strain S10. Microbial Cell Factories. Aug 11;17(1):124.
4. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2017. Cloning, evaluation, and high-level expression of a thermo-alkaline pectate lyase from alkaliphilic Bacillus clausii with potential in ramie degumming. Applied Microbiology and Biotechnology. 101:3663–3676.
5. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2017. Characterization and overproduction of a thermo-alkaline pectatelyase from alkaliphilic Bacillus licheniformis with potential in ramie degumming. Process Biochemistry. 49-58.
6. Caili Zhang#, Cheng Zhou#, Nilnate Assavasirijinda, Bo Yu, Limin Wang* and Yanhe Ma. 2017. Non-sterilized fermentation of high optically pure d-lactic acid by a genetically modified thermophilic Bacillus coagulans strain. Microbial Cell Factories. 16:213.
7. Meixia Liu, Chun-Chi Chen, Lu Chen, Xiansha Xiao, Yingying Zheng, Jian-Wen Huang, Weidong Liu, Tzu-Ping Ko, Ya-Shan Cheng, Xinxin Feng, Eric Oldfield, Rey-Ting Guo*, Yanhe Ma*. 2016. Structure and Function of a “Head-to-Middle” Prenyltransferase: Lavandulyl Diphosphate Synthase. Angewandte Chemie-International Edition. pr 4;55(15):4721-4.
8. Deyong Ge, Yanfen Xue, Yanhe Ma*. 2016. Two unexpected promiscuous activities of the iron–sulfur protein IspH in production of isoprene and isoamylene. Microbial Cell Factories. 15:79.
9. Nilnate Assavasirijinda, Deyong Ge, Bo Yu, Yanfen Xue, Yanhe Ma*. 2016. Efficient fermentative production of polymer-grade d-lactate by an engineered alkaliphilic Bacillus sp. strain under non-sterile conditions. Microbial Cell Factories. 15:3.
10. Yajian Song, Jinshan Li, Shan Meng, Liang Yin, Yanfen Xue, Yanhe Ma*. 2016. A Novel Manno-Oligosaccharide Binding Protein Identified in Alkaliphilic Bacillus sp. N16-5 Is Involved in Mannan Utilization. PLoS One. 11(3):e0150059.
11. Kai Jiang, Yanfen Xue, Yanhe Ma*. 2015. Identification of N(α)-acetyl-α-lysine as a probable thermolyte and its accumulation mechanism in Salinicoccus halodurans H3B36. Scientific Reports. 5: 18518.
12. Kai Jiang, Yanfen Xue, Yanhe Ma*. 2015. Complete genome sequence of Salinicoccus halodurans H3B36, isolated from the Qaidam Basin in China. Standards in Genomic Sciences. 10:116.
13. Cheng Zhou, Jintong Ye, Yanfen Xue, Yanhe Ma*. 2015. Directed Evolution and Structural Analysis of Alkaline Pectate Lyase from the Alkaliphilic Bacterium Bacillus sp. Strain N16-5 To Improve Its Thermostability for Efficient Ramie Degumming. Applied and Environmental Microbiology. 81(17): 5714-5723.
14. Cheng Zhou, Yanfen Xue, Yanhe Ma*. 2015. Evaluation and directed evolution for thermostability improvement of a GH 13 thermostable α-glucosidase from Thermus thermophilus TC11. BMC Biotechnology. 15:97.
15. Liang Yin, Yanfen Xue, Yanhe Ma*. 2015. Global Microarray Analysis of Alkaliphilic Halotolerant Bacterium Bacillus sp. N16-5 Salt Stress Adaptation. PLoS One. 10(6): e0128649.
16. Lei Zhai, Yanfen Xue, Yuehao Song, Mingjie Xian, Liang Yin, Naiqin Zhong, Guixian Xia, Yanhe Ma*. 2014. Overexpression of AaPal, a peptidoglycan-associated lipoprotein from Alkalomonas amylolytica, improves salt and alkaline tolerance of Escherichia coli and Arabidopsis thaliana. Biotechnology Letters. 36(3): 601-607.
17. Yajian Song, Yanfen Xue, Yanhe Ma*. 2013. Global Microarray Analysis of Carbohydrate Use in Alkaliphilic Hemicellulolytic Bacterium Bacillus sp. N16-5. PLoS One. 8(1): e54090.
18. Lang Rao, Yanfen Xue, Yingying Zheng, Jian R. Lu*, Yanhe Ma*. 2013. A Novel Alkaliphilic Bacillus Esterase Belongs to the 13th Bacterial Lipolytic Enzyme Family. PLoS One. 8(4): e60645.
19. Wenqin Bai, Yanfen Xue, Cheng Zhou, Yanhe Ma*. 2012. Cloning, expression and characterization of a novel salt tolerant xylanase from Bacillus sp. SN5. Biotechnology Letters. 34: 2093–2099.
20. Ying Meng, Yanfen Xue, Bo Yu, Chenghua Gao, Yanhe Ma*. 2012. Efficient production of L-lactic acid with high optical purity by alkaliphilic Bacillus sp. WL-S20. Bioresource Technology. 116: 334–339."
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