刘钢 - 中国科学院微生物研究所 -

个人简介

组长工作经历 2008.09- 现在中国科学院微生物研究所真菌学国家重点实验室，研究员 2007.04- 2008.08 中国科学院微生物研究所微生物资源前期开发国家重点实验室，研究员 2001.10- 2007.03 中国科学院微生物研究所，副研究员 2000.05- 2001.10 美国Texas A&M大学植物病理及微生物系，博士后 1998.09- 2000.05 西班牙Leon大学微生物系，博士后组长教育背景 1995.09- 1998.08 中国科学院微生物研究所，遗传学，博士学位 1992.09- 1995.07 南开大学，微生物学，硕士学位 1988.09- 1992.07 南开大学，微生物学，学士学位

研究领域

主要从事丝状真菌次级代谢产物的生物合成及其调控研究

近期论文

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Liu Gang, Keith Chater，Govind Chandra, Niu Guoqing, and Tan Huarong*. (2013) Molecular Regualtion of antibiotic biosynthesis in Streptomyces. Microbiology and Molecular Biology Review, 77 (1), 112-143. Pan Yuanyuan, Lu Cheng, Dong Hailing, Yu Lingjun, Liu Gang, Tan Huarong. (2013) Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor. Microb Cell Fact. 12(1):65. Long Liangkun, Wang Yanling, Yang Jing, Xu Xinxin, Liu Gang*. (2013) A septation related gene AcsepH in Acremonium chrysogenum is involved in the cellular differentiation and cephalosporin production. Fungal Genetics and Biology. 50:11-20. Liu Li, Long Liang-kun, An Yang, Yang Jing, Xu Xinxin, Hu Chang-hua*, Liu Gang*. (2013) The thioredoxin reductase-encoding gene ActrxR1 is involved in the cephalosporin C production of Acremonium chrysogenum in methionine-supplemented medium. Appl Microbiol Biotechnol. 97(6):2551-2562. Liu L, Li Y, Li L, Cao Y, Guo L, Liu G, Che Y. 2013. Spiroketals of Pestalotiopsis fici provide evidence for a biosynthetic hypothesis involving diversified Diels-Alder reaction cascades. J Org Chem. 78(7):2992-3000. doi: 10.1021/jo302804h. Ren Jinwei, Zhang Fan, Liu Xiangyu, Li Li, Liu Gang*, Liu Xingzhong, Che Yongsheng*.(2012) Neonectrolide A, a New Oxaphenalenone Spiroketal from the Fungus Neonectria sp. Org Lett. 14(24):6226-6229. Yang Jing, Xu Xinxin, Liu Gang*. (2012) Amplification of a MFS transporter encoding gene penT significantly stimulates penicillin production and enhances the sensitivity of Penicillium chrysogenum to phenylacetic acid. Journal of Genetics and Genomics. 39:593-602. Long Liangkun, Yang Jing, An Yang, Liu Gang*. (2012) Disruption of a glutathione reductase encoding gene in Acremonium chrysogenum leads to reduction of its growth, cephalosporin production and antioxidative ability which is recovered by exogenous methionine. Fungal Genetics and Biology. 49: 114–122. Xu Xinxin, Yang Jing, An Yang, Pan Yuanyuan, Liu Gang*. (2012) Over-expression of pcvA involved in vesicle-vacuolar fusion affects the conidiation and penicillin production in Penicillium chrysogenum. Biotechnol Lett. 34:519–526. LI Erwei, ZHANG Fan, NIU Shubin, LIU Xingzhong, LIU Gang,Che Yongsheng*. 2012. A spiro[chroman-3,7'-isochromene]-4,6'(8'H)-dione from the Cordyceps-colonizing fungus Fimetariella sp. Organic Letters 14(13):3320-3323. An Yang, Dong Hailing, Liu Gang*. (2012) Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum. J Ind Microbiol Biotechnol. 39:269–274.