李寅 - 中国科学院微生物研究所 -

个人简介

学习经历 1991-1995 无锡轻工大学，发酵工程专业，学士 1995-2000 无锡轻工大学，发酵工程专业，博士工作经历 2000-2001 江南大学生物工程学院，讲师 2001-2002 荷兰瓦赫宁根食品科学中心，博士后 2003-2004 江南大学生物工程学院，副教授 2004-2006 爱尔兰国立科克大学，研究员 2006-至今中国科学院微生物研究所研究员、博士生导师 2007-2008 中国科学院微生物研究所能源与工业生物技术中心主任 2013-2014 美国康奈尔大学生物与环境工程系，访问教授 2013-2015 中国科学院微生物生理与代谢工程重点实验室主任

研究领域

微生物及其代谢转化反应在维持地球物质循环和生命网络中起着关键作用。认识、理解、改造和利用微生物的代谢转化能力，对促进微生物在食品、医药、化工、材料和能源领域的应用，具有重要意义。本课题组致力于与微生物代谢转化相关的分子生理学与代谢工程研究，重点关注两个问题，一是如何将无机碳高效转化为有机碳；二是如何将有机碳高效转化为有用的物质

近期论文

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Gong F, Li Y*. Fixing carbon, unnaturally. Science, 2016, 354(6314): 830-831. Zhou J, Li Y*. SNPs deciding the rapid growth of cyanobacteria are alterable. Proc. Natl. Acad. Sci. USA, 2019, doi:10.1073/pnas.1900210116. Zhang Y, Li Y*. Engineering the antioxidative properties of lactic acid bacteria for improving its robustness. Curr. Opin. Biotechnol., 2013, 24(2): 142-147. Zhu L, Zhu Y, Zhang Y, Li Y*. Engineering the robustness of industrial microbes through synthetic biology. Trends Microbiol., 2012, 20(2): 94-101. Zhang Y, Zhu Y, Zhu Y, Li Y*. The importance of engineering physiological functionality into microbes. Trends Biotechnol., 2009, 27(12): 664-672. Hu G#, Zhou J#, Chen X, Qian Y, Gao C, Guo L, Xu P, Chen W, Chen J, Li Y, Liu L*. Engineering synergetic CO2-fixing pathways for malate production. Metab. Eng., 2018, 47:496-504. Zhou J, Zhang F-L, Meng H-K, Zhang Y, Li Y*. Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria. Metab. Eng., 2016, 38:217-227. Zhou J, Zhang H, Zhang Y, Li Y*, Ma Y. Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide. Metab. Eng., 2012, 14(4): 394-400. Dong H, Zhao C, Zhang T, Zhu H, Lin Z, Tao W, Zhang Y, Li Y*. A systematically chromosomally engineered Escherichia coli efficiently produces butanol. Metab. Eng., 2017, 44(2): 284-292 Dong H#, Tao W#, Zhang Y, Li Y*. Development of an anhydrotetracycline- inducible gene expression system for solvent-producing Clostridium acetobutylicum: A useful tool for strain engineering. Metab. Eng., 2012, 14(1): 59-67. Zhu L, Dong H, Zhang Y*, Li Y*. Engineering the robustness of Clostridium acetobutylicum by introducing glutathione biosynthetic capability. Metab. Eng., 2011, 13(4): 426-434. Zhang Y, Huang Z, Du C, Li Y*, Cao Z*. Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol. Metab. Eng., 2009, 11(2): 101-106 Zhang Y, Li Y, Du C, Liu M, Cao Z*. Inactivation of aldehyde dehydrogenase: a key factor for engineering 1,3-propanediol production by Klebsiella pneumoniae. Metab. Eng., 2006, 8(6): 578-586. Fu R-Y, Bongers BS, van Swam II, Chen J, Molenaar D, Kleerebezem M, Hugenholtz J, Li Y*. Introducing glutathione biosynthetic capability into Lactococcus lactis subsp. cremoris NZ9000 improves the oxidative-stress resistance of the host. Metab. Eng., 2006, 8(6): 662-671. Gong F, Liu G, Zhai X, Zhou J, Cai Z*, Li Y*. Quantitative analysis of an engineered CO2-fixing Escherichia coli reveals great potential of heterotrophic CO2 fixation. Biotechnol. Biofuels, 2015, 8: 86. Luan G, Cai Z*, Li Y*, Ma Y. Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production. Biotechnol. Biofuels, 2013, 6: 137. Dai Z, Dong H, Zhu Y, Zhang Y, Li Y*, Ma Y. Introducing a single secondary alcohol dehydrogenase into butanol-tolerant Clostridium acetobutylicum Rh8 switches ABE fermentation to high level IBE fermentation. Biotechnol. Biofuels, 2012, 5: 44. Zhao C, Lin Z, Dong H*, Zhang Y, Li Y*. Reexamination of the physiological role of PykA in Escherichia coli revealed that it negatively regulates the intracellular ATP levels under anaerobic conditions. Appl. Environ. Microbiol., 2017, 83(11): e00316-17 Zhu Y#, Li D#, Bao G, Wang S, Mao S, Song J, Li Y, Zhang Y*. Metabolic changes of Klebsiella oxytoca in response to low oxidoreduction potential revealed by comparative proteomic profiling integrated with flux balance analysis. Appl. Environ. Microbiol., 2014, 80(9): 2833-2841. Ge S, Zhu T*, Li Y. Expressing bacterial GshF in Pichia pastoris for glutathione production. Appl. Environ. Microbiol., 2012, 78(15): 5435-5439.