刘晓 - 中国科学院微生物研究所 -

个人简介

教育经历 2009.09-2014.07 中国农业大学，博士 2005.09-2009.07 山东农业大学, 本科工作经历 2019.03-present中国科学院微生物研究所真菌学国家重点实验室，项目研究员 2014.10-2019.03美国德克萨斯大学西南医学中心，博士后获奖情况 2014年北京市优秀毕业生 2013年中国农业大学校长奖学金 2013年博士研究生国家奖学金 2011年研究生创新专项项目基金

研究领域

生物钟是指生物生命活动的内在节律性，对于生物有效适应地球环境具有重要意义。生物钟几乎存在于所有生物体内，并通过生化反应、细胞、发育和行为等层面表现出来。生物钟基因突变会引发不同的人类疾病，例如睡眠障碍、情绪低落、代谢综合症以及癌症等。脉孢菌作为简单的真核生物，易于进行遗传操作，是研究生物钟的最佳模式生物之一。由于脉孢菌生物钟运行机制与高等哺乳动物相似，对脉孢菌生物钟的研究将促进我们对生物钟运行机制的理解

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Liu X, Dang Y, Matsu-Ura T, He Y, He Q, Hong CI, Liu Y. DNA replication is required for circadian clock function by regulating rhythmic nucleosome composition. Mol Cell. 2017 Jul 20;67(2):203-213.e4. (Highlighted by Nature Reviews Molecular Cell Biology) 2. Cao X*, Liu X*, Li H, Fan Y, Duan J, Liu Y and He Q. Transcription factor CBF-1 suppresses frequency transcription by modulating the proper binding of WHITE COLLAR complex in Neurospora. PLoS Genet. 2018 Sep; 14(9): e1007570. (* equal contribution) 3. Gai K, Cao X, Dong Q, Ding Z, Wei Y, Liu Y, Liu X, He Q. Transcriptional repression of frequency by the IEC-1-INO80 complex is required for normal Neurospora circadian clock function. PLoS Genet. 2017 Apr 12;13(4):e1006732. 4. Sun G*, Zhou Z*, Liu X*, Gai K, Liu Q, Cha J, Kaleri FN, Wang Y, He Q. Suppression of WHITE COLLAR-independent frequency transcription by histone H3 lysine 36 methyltransferase SET-2 is necessary for clock function in Neurospora. J Biol Chem. 2016 May 20;291(21):11055-63. (* equal contribution) 5. Liu X, Li H, Liu Q, Niu Y, Hu Q, Deng H, Cha J, Wang Y, Liu Y, He Q. Role for protein kinase A in the Neurospora circadian clock by regulating White Collar-independent frequency transcription through phosphorylation of RCM-1. Mol Cell Biol. 2015 Jun;35(12):2088-102. 6. Zhou Z*, Liu X*, Hu Q*, Zhang N, Sun G, Cha J, Wang Y, Liu Y, He Q. Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4867-74. (* equal contribution) DNA replication is required for circadian clock function by regulating rhythmic nucleosome composition. Liu X, et al., Mol Cell. 2017. (Highlighted by Nature Reviews Molecular Cell Biology) Role for protein kinase A in the Neurospora circadian clock by regulating White Collar-independent frequency transcription through phosphorylation of RCM-1. Liu X, et al., Mol Cell Biol. 2015 Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock. Zhou Z*, Liu X*, Hu Q*, et al., PNAS. 2013