个人简介
教育经历
1997-2001 武汉大学生命科学学院，理学学士
2001-2006 中国科学院生物物理研究所，理学博士
工作经历
2006-2018 中国科学院生物物理研究所 助理研究员/副研究员/项目研究员
2018-至今 中国科学院微生物研究所 项目研究员
近期论文
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Hou YJ, Yang WS, Hong Y, Zhang Y, Wang DC*, Li DF*. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. J Biol Chem. 2020 Jan 17;295(3):808-821.
Hong Y#, Huang Z#, Guo L, Ni B, Jiang CY, Li XJ, Hou YJ, Yang WS, Wang DC, Zhulin IB, Liu SJ*, Li DF*. The ligand-binding domain of a chemoreceptor from Comamonas testosteroni has a previously unknown homotrimeric structure. Mol Microbiol. 2019 Sep;112(3):906-917.
Zhao F, Hou YJ, Zhang Y, Wang DC*, Li DF*. The 1-β-methyl group confers a lower affinity of l,d-transpeptidase LdtMt2 for ertapenem than for imipenem. Biochem Biophys Res Commun. 2019 Mar 5;510(2):254-260.
Yang WS, Hong Y, Zhang Y, Wang DC*, Li DF*, Hou YJ*. A potential substrate binding pocket of BdcA plays a critical role in NADPH recognition and biofilm dispersal. Biochem Biophys Res Commun. 2018 Mar 11;497(3):863-868.
Feng N#, Qi C#, Hou YJ, Zhang Y, Wang DC*, Li DF*. The C2'- and C3'-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain. Biochem Biophys Res Commun. 2018 Mar 4;497(2):646-651.
Gao YR#, Li DF#, Fleming J#, Zhou YF, Liu Y, Deng JY, Zhou L, Zhou J, Zhu GF, Zhang XE, Wang DC*, Bi LJ*. Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis. Sci Rep. 2017 Jul 25;7(1):6471.
Zheng X#, Feng N#, Li D*, Dong X*, Li J*. New molecular insights into an archaeal RNase J reveal a conserved processive exoribonucleolysis mechanism of the RNase J family. Mol Microbiol. 2017 Nov;106(3):351-366.
Yang K#, Li DF#, Wang X, Liang J, Sitia R, Wang CC*, Wang X*. Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention. Structure. 2016 Oct 4;24(10):1755-1765.
Miao LL#, Hou YJ#, Fan HX, Qu J, Qi C, Liu Y, Li DF*, Liu ZP*. Molecular Structural Basis for the Cold Adaptedness of the Psychrophilic β-Glucosidase BglU in Micrococcus antarcticus. Appl Environ Microbiol. 2016 Jan 22;82(7):2021-30.
Qi C#, Li DF#, Feng L, Hou Y, Sun H, Wang DC*, Liu W*. Biochemical and structural characterization of a novel ubiquitin-conjugating enzyme E2 from Agrocybe aegeria reveals Ube2w family-specific properties. Sci Rep. 2015 Nov 3;5:16056.
Zhang XL#, Li DF#, Fleming J, Wang LW, Zhou Y, Wang DC, Zhang XE*, Bi LJ*. Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase. FASEB J. 2015 Dec;29(12):4804-14.
Fan S#, Li DF#, Wang DC, Fleming J, Zhang H, Zhou Y, Zhou L, Zhou J, Chen T, Chen G*, Zhang XE*, Bi L*. Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase. Int J Biochem Cell Biol. 2015 Jan;58:71-80.
Li WJ#, Li DF#, Hu YL, Zhang XE, Bi LJ*, Wang DC*. Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis. Cell Res. 2013 May;23(5):728-31.
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