陈义华 - 中国科学院微生物研究所 -

个人简介

教育经历 1994.9-1998.6 南京农业大学，大学本科 1998.9-2001.6 南京农业大学，硕士研究生 2001.9-2005.7 中国科学院微生物研究所，博士研究生工作经历 2006.7-2011.4 美国威斯康星大学—麦迪逊 (UW-Madison), 博士后、研究助理 2011.4-至今中国科学院微生物研究所，研究员

研究领域

细菌遗传学和天然产物化学交叉学科的基础上，主要从事微生物天然产物生物学合成机制的研究、代谢途径的工程学研究以及通过基因挖掘筛选小分子化合物

近期论文

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Li Jine#, Wang Min#, Ding Yong, Tang Yue, Zhang Zhiguo, Chen Yihua*. (2016) Involvement of an octose ketoreductase and two acyltransferases in the biosynthesis of paulomycins, Sci Rep. 6:1544-1549. Li Jine, Xie Zhoujie, Wang Min, Ai Guoming, Chen Yihua*.(2015) Identification and Analysis of the Paulomycin Biosynthetic Gene Cluster and Titer Improvement of the Paulomycins in Streptomyces paulus NRRL 8115, PLoS One. 0(3):e0120542. Guo Zhengyan#, Li Jine#, Qin Hua#, Wang Min, Lv Xun, Li Xuebing, Chen Yihua*. (2015) Biosynthesis of the Carbamoylated D-Gulosamine Moiety of Streptothricins: Involvement of a Guanidino-N-glycosyltransferase and an N-Acetyl-D-gulosamine Deacetylase, Angewandte Chemie. 54: 1-5. Li Pengwei, Li Jine, Guo Zhengyan, Tang Wei, Han Jianshan, Meng Xiangxi, Hao Tingting, Zhu Yaxin, Zhang Lixin, Chen Yihua*. (2015) An efficient blue-white screening based gene inactivation system for Streptomyces, Appl Microbiol Biotechnol. 99: 1923-1933. Haiyan Chen, Ning Liu, Ying Huang, Yihua Chen.（2014） Isolation of an anthrabenzoxocinone 1.264-C from Streptomyces sp. FXJ1.264 and absolute configuration determination of the anthrabenzoxocinones. Tetrahedron: Asymmetry 25:113–116. Jine Li, Zhengyan Guo, Wei Huang, Xiangxi Meng, Guomin Ai, Gongli Tang and Yihua Chen. (2013) Mining of a streptothricin gene cluster from Streptomyces sp. TP-A0356 genome via heterologous expression. Sci China Life Sci. 56:619-627. Yihua Chen, Min Yin, Geoff P. Horsman, and Ben Shen. (2011) Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation in Streptomyces globisporus. Journal of Natural Products 74:420-424. Yihua Chen, Evelyn Wendt-Pienkowski, Jianhua Ju, Shuangjun Lin, Scott R. Rajski, and Ben Shen. (2010) Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. The Journal of Biological Chemistry 285: 38853-38860. Geoff P. Horsman*, Yihua Chen*, Jon S. Thorson, and Ben Shen. (2010) Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.Proc. Natl. Acad. Sci.USA 107: 11331-11335 (*co-first author) Yihua Chen, Min Yin, Geoff P. Horsman, Shengxiong Huang, and Ben Shen. (2010) Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. The Journal of Antibiotics 63: 482-485. Yihua Chen*, Keqiang Fan*, Yongzhi He, Xinping Xu, Yanfeng Peng, Tingting Yu, Cuijuan Jia and Keqian Yang. (2010) Characterization of JadH as an FAD- and NAD(P)H-dependent bifunctional hydroxylase/dehydrase involved in jadomycin biosynthesis.ChemBioChem. 11: 1055-1060. (*co-first author) Yihua Chen, Micheal J Smanski, and Ben Shen. (2010) Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Applied Microbiology and Biotechnology 86: 19-25. Yihua Chen, Evelyn Wendt-Pienkoski, Scott R. Rajski, and Ben Shen (2009) In vivoinvestigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases. The Journal of Biological Chemistry 284: 24735-24743. Yihua Chen, Evelyn Wendt-Pienkowski, and Ben Shen (2008) Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. Journal of Bacteriology 190: 5587-5596. Yihua Chen, Yinggang Luo, Jianhua Ju, Evelyn Wendt-Pienkowski, Scott R. Rajski, and Ben Shen. (2008) Identification of fredericamycin E from Streptomyces griseus: insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation.Journal of Natural Products 71: 431-437.