王言才 - 齐鲁工业大学 - 化学与制药工程学院

研究领域

1．纳米结晶速释及缓控释制剂开发：依托纳米技术，解决新药开发中药物制剂学相关难题，特别是通过纳米结晶技术，实现难溶性候选化合物的制剂开发。目前，已经完成水飞蓟宾、葛根素等多个品种的药学研究、稳定性试验和初步的安全性评价，并获得黄豆苷元纳米结晶速释胶囊等多项专利技术。 2．新型缓控释中药制剂开发：主要是采用缓控释微丸技术，针对当前中药有效部位进行开发，实现中药药剂的时辰药理学给药和靶部位释药，实现释放时间和释药部位的控制。

近期论文

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[1] YancaiWang*, Ying Zheng, Ling Zhang, Qiwei Wang, Dianrui Zhang. Stability of nanosuspensions in drug delivery. Journal of Controlled Release 172 (3): 1126–1141, 2013. 影响因子：7.2 [2] Yancai Wang, Ying Zheng*, Xiaoqing Miao, Lin Sun, Ju Song, Chao Bi. Effects of nanosuspension formulations on transport, pharmacokinetics, in vivo targeting and efficacy for poorly water-soluble drugs. Current Pharmaceutical Design, Invited manuscript, Epub ahead of print, PMID: 23651402, 2013. [3] Yancai Wang*, Yingying Ma, Ying Zheng, Ju Song, Xiao Yang, Chao Bi, Dianrui Zhang, Qiang Zhang. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. International Journal of Pharmaceutics, 441(1): 728-735, 2013. [4] Ju Song, Yancai Wang, Yuelin Song, Hokman Chan, Chao Bi, Xiao Yang, Ru Yan, Yitao Wang, Ying Zheng*. Development and Characterizations of Nanocrystals without Stabilizer of Ursolic Acid with Improved Dissolution Rate and In-vitro Anticancer Activity. AAPS PharmSciTech, in press, 2013. [5] Yancai Wang*, Ling Zhang, Qiwei Wang, Dianrui Zhang. Recent Advances in the Nanotechnology-Based Drug Delivery of Silybin. Journal of Biomedical Nanotechnology, 10(4): 543-558, 2014. 影响因子：7.5 [6] Yancai Wang*, Zhaoping Liu, Dianrui Zhang, Yi Ma, Qiang Zhang. In vivo evaluation of silybin nanosuspensions targeting liver. Journal of Biomedical Nanotechnology. 8(1): 107-115, 2012. 影响因子：7.5 [7] Yancai Wang*, Yi Ma, Yingying Ma, Yongli Du, Dianrui Zhang, Qiang Zhang. Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. Journal of Nanoscience and Nanotechnology, 12(8): 6176-6784, 2012. [8] Yancai Wang, Zhaoping Liu*, Dianrui Zhang*, Xihui Gao, Cunxian Duan, Lejiao Jia, Yaojian Huang, Yuemao Shen, Qiang Zhang. Development and in vitro evaluation of Deacety Mycoepoxydiene nanosuspension. Colloids and Surfaces B: Biointerfaces, 83(2): 189-197, 2011. [9] Dandan Zheng, Yancai Wang, Dianrui Zhang*, Zhaoping Liu, Guangpu Liu, Leilei Hao, Qiang Zhang. In vitro antitumor activity of silybin nanosuspension in PC-3 cells. Cancer Letters, 307(2): 158-164, 2011. [10] Yancai Wang, Dianrui Zhang*, Zhaoping Liu, Guangpu Liu, Cunxian Duan, Lejiao Jia, Feifei Feng, Xiaoyu Zhang, Yanqiu Shi, Qiang Zhang. In vitro and in vivo evaluation of silybin nanosuspensions for oral and intravenous delivery. Nanotechnology, 21(15): 155104, 2010. [11] 王言才, 刘兆平, 张典瑞*, 许家星, 段存贤, 王飞虎, 张强. LC/MS法测定犬血浆中的水飞蓟宾浓度. 中国药理学通报, 26(5): 679-683, 2010. [12] 王言才, 马迎迎, 王会豪. 黄豆苷元纳米结晶速释胶囊及制备工艺[P], 2012.12, 中国, 授权公告号：CN 102274202 B.