Sligar, Stephen G. - University of Illinois at Urbana-Champaign

个人简介

Stephen G. Sligar received his Ph.D. in Physics from the University of Illinois in 1975. Dr. Sligar served on the faculty in the Department of Molecular Biophysics and Biochemistry at Yale University and returned to the University of Illinois in 1982 where he was the I. C. Gunsalus Professor of Biochemistry. He now holds the University of Illinois Swanlund Endowed Chair and is Director of the School of Molecular and Cellular Biology. He is also a faculty member in the Department of Chemistry, the Center for Biophysics and Computational Biology and the College of Medicine. Dr. Sligar holds affiliate appointments in the Beckman Institute for Advanced Science and Technology, the Institute for Genomic Biology and The Micro and Nano Technology Laboratory on the Illinois campus. He is a Fellow of the Biophysical Society and the American Association for the Advancement of Science. Awards include a Fulbright Research Scholarship, Senior Fellowship from the Japan Society for the Promotion of Science, an NIH Merit Award and the Bert L. and Kuggie Vallee Visiting Professorship in Inorganic Chemistry at Oxford where he was a Fellow of Queens College. He is also a Fellow in the Jerome Karle Nobel Laureate World Innovation Foundation. Dr. Sligar's research is supported by grants from the National Science Foundation, the National Institutes of Health and the Human Frontiers Program. Research centers on understanding the structure and mechanistic function of metalloenzymes, membrane bound receptors and transporters as well as investigations in blood coagulation and amyloid proteins and their corresponding human disease states.

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Khatri, Y., Luthra, A., Duggal, R. and Sligar, S. G. (2014) "Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.", FEBS Letters, 588 (17), 3117- 3122. Mak, P. J., Luthra, A., Sligar, S. G. and Kincaid, J. R. (2014) "Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step.", J. Am. Chem. Soc., 136 (13), 4825-4828. Khatri, Y., Gregory, M. C., Grinkova, Y. V., Denisov, I. G., Sligar, S. G. (2014) "Active site proton delivery and the lyase activity of human CYP17A1.”, Biochem. Biophys. Res. Commun., 443(1), 179-184. PMID: 24299954 D'Antona, A. M., Xie, G., Sligar, S. G., Oprian, D. D. (2014) "Assembly of an Activated Rhodopsin/Transducin Complex in Nanoscale Lipid Bilayers”, Biochemistry. 53(1), 127-134. Mak, P. J., Gregory, M. C., Sligar, S. G,. Kincaid, J. R. (2014) "Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.", Biochemistry, 53(1), 90-100. PMID: 24328388 Marty, M. T., Zhang, H., Cui, W., Gross, M. L., Sligar, S. G. (2013) "Interpretation and Deconvolution of Nanodisc Native Mass Spectra”, J. Am. Soc. Mass. Spectrom. 25(2), 269-277. PMID: 24353133 Gregory, M. C., Denisov, I. G., Grinkova, Y. G., Khatri, Y. and Sligar S. G. (2013) "Kinetic Solvent Isotope Effect in Human P450 CYP17A1-Mediated Androgen Formation: Evidence for a Reactive Peroxoanion Intermediate.", J. Am. Chem. Soc., 135 (44), 16245-16247. PMID: 24160919 Sun, Y., Zeng, W., Benabbas, A., Ye, X., Denisov, I., Sligar, S.G., Du, J., Dawson, J. H., and Champion, P. M. (2013) "Investigations of Heme Ligation and Ligand Switching in Cytochromes P450 and P420." Biochemistry, 52 (34), 5941-5951. PMID: 23905516 Vishnivetskiy, S. A., Ostermaier, M. K., Singhal, A., Panneels, V., Homan, K. T., Glukhova, A., Sligar, S.G., Tesmer, J. J., Schertler, G. F., Standfull, J., and Gurevich, V. V. (2013) "Constitutively Active Rhodopsin Mutants Causing Night Blindness are Effectively Phosphorylated by GRKs but Differ in Arrestin-1 Binding." Cell Signal. 25(11): 2155-2162. PMID: 23872075 Baylon, J. L., Lenov, I., Sligar, S. G., and Tajkhorshid, E. (2013) "Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation." J. Am. Chem. Soc. 135, 8542-8551. PMID: 23697766; PMCID: PMC3682445 Luthra, A., Gregory, M., Grinkova, Y. V., Denisov, I. G., Sligar, S. G. (2013) "Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes." Methods Mol. Biol., 987, 115-127. PMID: 23475672 Numata, M., Grinkova, Y. V. , Mitchell, J. R. , Chu, Hong Wei, Sligar, S. G., Voelker D. R. (2013) "Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung." International Journal of Nanomedicine, 8, 1417-1427. PMID: 23717040 Gregory, M., Mak, P.J., Sligar, S. G., and Kincaid, J.R. (2013) "Differential Hydrogen Bonding in Human CYP17 Dictates Hydroxylation Versus Lyase Chemistry.” Angewandte Chemie, Int. Ed. 52, 5342-5345. PMID: 23576395 Sloan, C. D., Marty, M. T., Sligar, S. G., Bailey, R. C. (2013) "Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening." Anal. Chem., 85(5), 2970-2976. PMID: 23425255 Marty, M. T., Wilcox, K. C., Klein, W. L., Sligar, S. G. (2013) "Nanodisc-solubilized membrane protein library reflects the membrane proteome." Anal. Bioanal. Chem., 405, 4009-4016. PMID: 23400332 Schuler, M. A., Denisov, I. G., Sligar, S. G. (2013) "Nanodiscs as a new tool to examine lipid-protein interactions." Methods Mol Biol. 974, 415-433. PMID: 23404286 Grinkova, Y. G., Denisov, I. G., McLean, M. A., Sligar, S. G. (2013) "Oxidase Uncoupling in Heme Monoxygenases: Human Cytochrome P450 CYP3A4 in Nanodiscs." Biochem. Biophys. Res. Comm., 430 (4), 1223-1227. PMID: 23266608