个人简介

BS (Honors) 1985, Illinois Institute of Technology; M Phil, 1987; PhD, 1990, Yale University; NSF Postdoctoral Fellowship, 1990, M.I.T.

研究领域

Organic Chemistry/Biomedical and Materials Applications of Nanosystems

A key issue in the use of nanomaterials is controlling the interfacial interactions of these complex systems. Our research program focuses on the tailoring of interfaces through the atomic-level control provided by organic synthesis. Using these tailored monolayers, we have developed particles for biological applications, including highly effective gene and drug delivery agents and sensors for the identification of pathogens. Concurrently, we are using nanoparticles as building blocks for the creation of new functional materials. In our research we couple synthetic capability with nanomaterials characterization and top-down fabrication techniques, providing access to materials an devices structured on all length scales. Underlying our efforts to create functional materials is an abiding curiosity of the fundamental nature of soft materials, including supramolecular assembly, collective and emergent behavior, surface science, and interfacial phenomena.

近期论文

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Ward, A. J.; Ruseckas, A.; Kareem, M. M.; Ebenhoch, B.; Serrano, L. A.; Al-Eid, A.; Fitzpatrick, B.; Rotello, V. M.; Cooke, G.; Samuel, I. D. W. "The Impact of Driving Force on Electron Transfer Rates in Photovoltaic Donor–Acceptor Blends" Adv. Mater. 2015, Early View. Ebenhoch, B.; Prasetya, N. B. A.; Rotello, V. M.; Cooke, G.; Samuel, I. D. W. "Solution-processed Boron Subphthalocyanine Derivatives as Acceptors for Organic Bulk-heterojunction Solar Cells" J. Mater. Chem. A 2015, Advance Article. Jeoung, E.; Yeh, Y.-C.; Nelson, T.; Kushida, T.; Wang, L.-S.; Mout, R.; Li, X.; Saha, K.; Gupta, A.; Tonga, G. Y.; Lannutti, J. J.; Rotello, V. M. "Fabrication of Functional Nanofibers Through Post-Nanoparticle Functionalization" Macromol. Rapid Commun. 2015, Early View. Kim, C.; Tonga, G. Y.; Yan, B.; Kim, C. S.; Kim, S. T.; Park, M.-H.; Zhu, Z.; Duncan, B.; Creran, B.; Rotello, V. M. "Regulating Exocytosis of Nanoparticles via Host-Guest Chemistry" Org. Biomol. Chem. 2015, 13, 2474-2479. Rana, S.; Le, N. D. B.; Mout, R.; Saha, K.; Tonga, G. Y.; Bain, R. E. S.; Miranda, O. R.; Rotello, C. M.; Rotello, V. M. "A Multichannel Nanosensor for Instantaneous Readout of Cancer Drug Mechanisms" Nat. Nanotechnol. 2015, 10, 65-69. Article highlighted on ScienceDaily, Science360, UMass News, Nanotechweb.org. Jiang, Y.; Tang, R.; Duncan, B.; Jiang, Z.; Yan, B.; Mout, R.; Rotello, V. M. "Direct Cytosolic Delivery of siRNA Using Nanoparticle-Stabilized Nanocapsules" Angew. Chem. Int. Ed. 2015, 54, 506-510. Article selected as Hot Topics of Wiley-VCH on RNA (Screenshot). Duncan, B.; Landis, R. F.; Jerri, H. A.; Normand, V.; Benczédi, D.; Ouali, L.; Rotello, V. M. "Hybrid Organic–Inorganic Colloidal Composite ‘Sponges’ via Internal Crosslinking" Small 2015, 11, 1302-1309. Article featured as Frontispiece. Fang, B.; Jiang, Y.; Nüsslein, K.; Rotello, V. M.; Santore, M. M. "Antimicrobial Surfaces Containing Cationic Nanoparticles: How Immobilized, Clustered, and Protruding Cationic Charge Presentation Affects Killing Activity and Kinetics" Colloids Surf., B 2015, 125, 255-263. Li, X.; Yeh, Y.-C.; Giri, K.; Mout, R.; Landis, R.; Prakash, Y. S.; Rotello, V. M. "Control of Nanoparticle Penetration into Biofilms through Surface Design" Chem. Commun. 2015, 51, 282-285. Ekmekci, Z.; Saha, K.; Moyano, D. F.; Tonga, G. Y.; Wang, H.; Mout, R.; Rotello, V. M. "Probing the Protein–nanoparticle Interface: The Role of Aromatic Substitution Pattern on Affinity" Supramol. Chem. 2015, 27, 123-126.